局部应用米诺环素软膏与甲硝唑凝胶治疗牙周炎临床分析(1)
摘要：目的 分析局部应用米诺环素软膏与局部应用甲硝唑凝胶治疗牙周炎的临床效果。方法 以我院口腔门诊收治的110例慢性牙周炎患者为例，使用随机的方法将110例患者分为对照组和观察组各55例，对照组采用局部应用甲硝唑凝胶治疗，观察组患者予以局部应用米诺环素软膏治疗，对比两组患者的治疗结果。结果 观察组的治疗有效率及不良反应发生率优于对照组，P<0.05；治疗后观察组的牙菌斑指数(PLT)、牙周袋深度(PD)、龈沟出血指数(SBI)、牙龈指数(GI)等牙周指标均优于对照组，两组间差异明显，P<0.05。结论 在牙周炎的治疗中应用米诺环素软膏局部治疗的效果优于甲硝唑凝胶，能够更好的改善患者的牙周指标，且不良反应少，值得临床推广。
关键词：甲硝唑凝胶；米诺环素软膏；牙周炎
Clinical Analysis of Topical Application of Minocycline Ointment and Topical Application of Metronidazole Gel in the Treatment of Periodontitis
, 百拇医药
ZHANG Xiao-yun
(Dazhou Qiyun Stomatology Department，Dazhou 635000，Sichuan，China)
Abstract：Objective To analyze the clinical effect of topical application of minocycline ointment and topical metronidazole gel in the treatment of periodontitis. Methods One hundred and ten patients with chronic periodontitis were divided into two groups： the control group and the observation group (55 cases). The control group was treated with metronidazole gel， Patients in the observation group were treated with minocycline ointment topically and the results were compared between the two groups. Results The effective rate of treatment and the incidence of adverse reactions were better in the observation group than those in the control group (P <0.05). After treatment， the plaque index (PLT)， depth of periodontal pocket (PD)， sulcus bleeding index (SBI) Gingival index (GI) and other periodontal indicators were better than the control group， the difference between the two groups was significant， P<0.05. Conclusion Minocycline ointment is superior to metronidazole gel in the treatment of periodontitis. It can improve the periodontal index of the patients and has less adverse reactions. It is worthy to be popularized.
, 百拇医药
Key words：Metronidazole gel； Minocycline ointment；Periodontitis
牙周炎是一種侵犯牙周组织及牙龈的慢性炎症，患者可出现牙周袋并形成袋壁的炎症，并出现牙槽骨吸收、牙龈出血、红肿及牙齿松动的情况。对于牙周炎的治疗主要是消除病因及炎症，恢复软组织及骨的外形，促进牙周组织的再生，使牙周恢复正常的功能[1]。盐酸米诺环素软膏与甲硝唑凝胶是临床常用的治疗牙周炎的药物，在本次的研究中，笔者以我院收治的慢性牙周炎患者为例，分析局部应用米诺环素软膏与甲硝唑凝胶治疗牙周炎的效果，结果做如下报道：
1 资料与方法
1.1 一般资料 研究所选取110例患者为我院牙科门诊在2015～2016年收治，按照患者就诊时间排号，使用随机单盲法将患者分为对照组和观察组各55例。对照组中男性患者30例，女性患者25例，患者年龄28～75岁，平均年龄(50.0±5.5)岁，病程5个月～10年，平均病程(4.5±1.5)年。观察组中男性患者29例，女性患者26例，患者年龄29～75岁，平均年龄(50.0±5.0)岁，病程6个月～10年，平均病程(4.8±1.5)年，两组患者的性别、年龄、病程等资料经统计学分析无显著差异，P>0.05。
1.2纳入标准 ①患者有不同程度的牙齿松动，牙龈红肿、出血，牙周疼痛及溢脓情况；②入院后X线检查具有一定程度的牙槽骨吸收，且牙周袋探针指数超过5 mm；③患者口腔内余牙查超过10颗，且入院前3个月未接受抗生素及其他牙周治疗；④本研究在实施前已征得患者同意，患者均签署之情同意书。
1.3排除标准 ①妊娠期及哺乳其女性患者；②相关药物过敏患者；③合并有口腔内其他疾病及伴有严重的感染性疾病、全身重要器官器质性疾病患者。, 百拇医药(张晓云)
关键词：甲硝唑凝胶；米诺环素软膏；牙周炎
Clinical Analysis of Topical Application of Minocycline Ointment and Topical Application of Metronidazole Gel in the Treatment of Periodontitis
, 百拇医药
ZHANG Xiao-yun
(Dazhou Qiyun Stomatology Department，Dazhou 635000，Sichuan，China)
Abstract：Objective To analyze the clinical effect of topical application of minocycline ointment and topical metronidazole gel in the treatment of periodontitis. Methods One hundred and ten patients with chronic periodontitis were divided into two groups： the control group and the observation group (55 cases). The control group was treated with metronidazole gel， Patients in the observation group were treated with minocycline ointment topically and the results were compared between the two groups. Results The effective rate of treatment and the incidence of adverse reactions were better in the observation group than those in the control group (P <0.05). After treatment， the plaque index (PLT)， depth of periodontal pocket (PD)， sulcus bleeding index (SBI) Gingival index (GI) and other periodontal indicators were better than the control group， the difference between the two groups was significant， P<0.05. Conclusion Minocycline ointment is superior to metronidazole gel in the treatment of periodontitis. It can improve the periodontal index of the patients and has less adverse reactions. It is worthy to be popularized.
, 百拇医药
Key words：Metronidazole gel； Minocycline ointment；Periodontitis
牙周炎是一種侵犯牙周组织及牙龈的慢性炎症，患者可出现牙周袋并形成袋壁的炎症，并出现牙槽骨吸收、牙龈出血、红肿及牙齿松动的情况。对于牙周炎的治疗主要是消除病因及炎症，恢复软组织及骨的外形，促进牙周组织的再生，使牙周恢复正常的功能[1]。盐酸米诺环素软膏与甲硝唑凝胶是临床常用的治疗牙周炎的药物，在本次的研究中，笔者以我院收治的慢性牙周炎患者为例，分析局部应用米诺环素软膏与甲硝唑凝胶治疗牙周炎的效果，结果做如下报道：
1 资料与方法
1.1 一般资料 研究所选取110例患者为我院牙科门诊在2015～2016年收治，按照患者就诊时间排号，使用随机单盲法将患者分为对照组和观察组各55例。对照组中男性患者30例，女性患者25例，患者年龄28～75岁，平均年龄(50.0±5.5)岁，病程5个月～10年，平均病程(4.5±1.5)年。观察组中男性患者29例，女性患者26例，患者年龄29～75岁，平均年龄(50.0±5.0)岁，病程6个月～10年，平均病程(4.8±1.5)年，两组患者的性别、年龄、病程等资料经统计学分析无显著差异，P>0.05。
1.2纳入标准 ①患者有不同程度的牙齿松动，牙龈红肿、出血，牙周疼痛及溢脓情况；②入院后X线检查具有一定程度的牙槽骨吸收，且牙周袋探针指数超过5 mm；③患者口腔内余牙查超过10颗，且入院前3个月未接受抗生素及其他牙周治疗；④本研究在实施前已征得患者同意，患者均签署之情同意书。
1.3排除标准 ①妊娠期及哺乳其女性患者；②相关药物过敏患者；③合并有口腔内其他疾病及伴有严重的感染性疾病、全身重要器官器质性疾病患者。, 百拇医药(张晓云)
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