子宫内膜搔刮术在反复种植失败患者中的临床应用价值(2)
综上所述,我们认为通过对子宫内膜搔刮可以改善子宫内膜血流灌注和子宫内膜容受性,有利于子宫内膜与排卵的同步性。提高反復种植失败患者妊娠率。因此,对于不明原因、反复种植失败的患者,再次进入新的IVF-ET周期前,行子宫内膜搔刮术,损伤小且易于操作实施,显著改变子宫内膜容受性,提高IVF-ET周期妊娠率,在临床上具有可行性。
参考文献:
[1]Potdar N, Gelbaya T, Nardo LG .Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis[J].Reprod Biomed Online,2012,25:561-571.
[2]Baum M, Yerushalmi GM, Maman E, Kedem A, Machtinger R, Hourvitz A, Dor J. Does local injury to the endometrium before IVF cycle really affect treatment outcome? Results of a randomized placebo controlled trial[J].Gynecol Endocrinol,2012,28:933-936.
[3]Wise J.Endometnal scratching improves IVF pregnancy rate [J].BMJ,2013,347:6007.
[4]kalma Y,Granot I,Gnainsky Y,et al.Endometrial biopsy induced Gene modulation:first evidence for the expression of bladder transmembranal uroplakin Ib in human endometrium[J].Fertil Steril,2009,91:1042-1049.
[5]Barash A, Dekel N, Fieldust S, et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization[J].Fertil Steril ,2003,79:1317-1322.
[6]Li R, Hao G. Local injury to the endometrium: its effect on implantation[J].Curr Opin Obstet Gynecol,2009,21:236-239.
[7]Check, J.H., Nowroozi, K., Choe, J. et al.(1991) Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization[J].Fertil. Steril.,56,1173-1175.
编辑/张燕, 百拇医药(陈淼 邱志玲 陈雪梅)
参考文献:
[1]Potdar N, Gelbaya T, Nardo LG .Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis[J].Reprod Biomed Online,2012,25:561-571.
[2]Baum M, Yerushalmi GM, Maman E, Kedem A, Machtinger R, Hourvitz A, Dor J. Does local injury to the endometrium before IVF cycle really affect treatment outcome? Results of a randomized placebo controlled trial[J].Gynecol Endocrinol,2012,28:933-936.
[3]Wise J.Endometnal scratching improves IVF pregnancy rate [J].BMJ,2013,347:6007.
[4]kalma Y,Granot I,Gnainsky Y,et al.Endometrial biopsy induced Gene modulation:first evidence for the expression of bladder transmembranal uroplakin Ib in human endometrium[J].Fertil Steril,2009,91:1042-1049.
[5]Barash A, Dekel N, Fieldust S, et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization[J].Fertil Steril ,2003,79:1317-1322.
[6]Li R, Hao G. Local injury to the endometrium: its effect on implantation[J].Curr Opin Obstet Gynecol,2009,21:236-239.
[7]Check, J.H., Nowroozi, K., Choe, J. et al.(1991) Influence of endometrial thickness and echo patterns on pregnancy rates during in vitro fertilization[J].Fertil. Steril.,56,1173-1175.
编辑/张燕, 百拇医药(陈淼 邱志玲 陈雪梅)
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