奥硝唑治疗厌氧菌性盆腔感染的临床疗效观察(1)
摘要：目的 探讨观察奥硝唑治疗厌氧菌性盆腔感染的临床疗效。方法 本次研究患者资料为本院2014年8月～2015年8月收治的厌氧菌感染性盆腔炎患者150例，根据患者的就诊时间随机分为对照组和观察组，每组患者75例，两组患者在用药期间的不良反应，治疗前对宫颈分泌物进行采样测试厌氧菌感染情况，评价两组患者的治疗效果。结果 两组患者治疗后，对照组75例患者，治愈60例，显效10例，无效5例，总有效70例，总有效率93.3%；观察组75例患者，治愈70例，显效1例，无效4例，总有效71例，总有效率94.7%。两组患者在治疗后的治愈、显效、无效、总有效率数据无统计学差异(P>0.05)。在两组患者用药过程中，对照组发生21例不良反应，观察组发生3例不良反应，观察组的不良反应发生率明显少于对照组患者，且P<0.05统计学差异显著。结论 奥硝唑氯化钠注射液治疗厌氧菌引起的盆腔感染的临床效果显著，且不良反应发生率较低，值得在临床上广泛推广。
关键词：奥硝唑；厌氧菌；盆腔感染；临床疗效
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Abstract：Objective To investigate the clinical efficacy of ornidazole in the treatment of pelvic anaerobic infections.Methods This study with data for anaerobic bacteria in our hospital in August 2014～2015 year in August were 150 cases of infection of patients with pelvic inflammatory disease， according to the patient's treatment time were randomly divided into control group and observation group，75 cases each group of patients，adverse reaction two groups of patients during the treatment，before the treatment of cervical secretion samples of anaerobic bacteria infection test， to evaluate the therapeutic effect of two groups of patients.Results After treatment，the control group of 75 patients，60 cases were cured，markedly effective in 10 cases，5 cases were ineffective，the total effective 70 cases，the total effective rate was 93.3%；observation group of 75 patients，cured 70 cases，markedly 1 case，Ineffective in 4 cases，the total effective in 71 cases，the total effective rate of 94.7%.There was no significant difference in the total effective rate between the two groups(P> 0.05).In the two groups of patients in the course of medication，the control group occurred in 21 cases of adverse reactions， the observation group occurred in 3 cases of adverse reactions，the observation group of adverse reactions was significantly less than the control group， and P<0.05 statistically significant difference.Conclusion Ornidazole sodium chloride injection is effective in the treatment of pelvic infection caused by anaerobic bacteria，and the incidence of adverse reactions is low，it is worthy to be widely promoted in clinical practice.
, 百拇医药
Key words：Ornidazole；Anaerobic bacteria；Pelvic infection；Clinical efficacy
盆腔感染是女性生殖器官和周圍结缔组织发生的感染，因为感染而出现一些列炎症现象，盆腔感染的发生可能与急性盆腔炎、慢性盆腔炎、输卵管、盆腔和卵巢等情况有关，多为厌氧菌性盆腔感染[1]。当患者发生盆腔感染后不但会影响患者的正常生活，还会严重影响患者的生殖健康和生育能力[2]。对于厌氧菌性感染盆腔炎的治疗多采用硝基咪唑类抗生素，临床较为常见用药为甲硝唑、替硝唑和奥硝唑，本次研究奥硝唑治疗厌氧菌感染的盆腔炎患者的临床效果，现进行报道。
1资料与方法
1.1一般资料 本次研究患者资料为本院2014年8月～2015年8月收治的厌氧菌感染性盆腔炎患者150例，患者年龄在20～62岁，平均年龄(43.5±4.3)岁，患者病程为4d～11个月，平均病程(6.51±2.9)个月，两组患者无其他合并症及重要器官的严重疾病。入选患者均符合《妇产科学》盆腔感染的诊断标准，并排除以下患者：未成年患者，妊娠或普如期妇女，合并有严重肝肾功能障碍的患者，在入组研究前已经使用厌氧菌抗生素药物，或对本次研究药物有严重过敏的患者，患者自身意识不清或不愿参加试验的患者，患者在入组前均签署知情同意书并自愿入组参加治疗。根据患者的就诊时间随机分为对照组和观察组，每组75例，其中对照组患者年龄20～60岁，平均年龄(42.3±5.3)岁，病程5 d～10个月，平均病程(6.23±3.2)个月，观察组患者年龄22～57岁，平均年龄(45.3±4.2)岁，病程4 d～11个月，平均病程(5.46±3.2)个月，两组患者的临床资料如年龄、病程、感染情况等一般资料无统计学差异(P>0.05)可进行组间比较。, http://www.100md.com(刘立冬)
关键词：奥硝唑；厌氧菌；盆腔感染；临床疗效
, http://www.100md.com
Abstract：Objective To investigate the clinical efficacy of ornidazole in the treatment of pelvic anaerobic infections.Methods This study with data for anaerobic bacteria in our hospital in August 2014～2015 year in August were 150 cases of infection of patients with pelvic inflammatory disease， according to the patient's treatment time were randomly divided into control group and observation group，75 cases each group of patients，adverse reaction two groups of patients during the treatment，before the treatment of cervical secretion samples of anaerobic bacteria infection test， to evaluate the therapeutic effect of two groups of patients.Results After treatment，the control group of 75 patients，60 cases were cured，markedly effective in 10 cases，5 cases were ineffective，the total effective 70 cases，the total effective rate was 93.3%；observation group of 75 patients，cured 70 cases，markedly 1 case，Ineffective in 4 cases，the total effective in 71 cases，the total effective rate of 94.7%.There was no significant difference in the total effective rate between the two groups(P> 0.05).In the two groups of patients in the course of medication，the control group occurred in 21 cases of adverse reactions， the observation group occurred in 3 cases of adverse reactions，the observation group of adverse reactions was significantly less than the control group， and P<0.05 statistically significant difference.Conclusion Ornidazole sodium chloride injection is effective in the treatment of pelvic infection caused by anaerobic bacteria，and the incidence of adverse reactions is low，it is worthy to be widely promoted in clinical practice.
, 百拇医药
Key words：Ornidazole；Anaerobic bacteria；Pelvic infection；Clinical efficacy
盆腔感染是女性生殖器官和周圍结缔组织发生的感染，因为感染而出现一些列炎症现象，盆腔感染的发生可能与急性盆腔炎、慢性盆腔炎、输卵管、盆腔和卵巢等情况有关，多为厌氧菌性盆腔感染[1]。当患者发生盆腔感染后不但会影响患者的正常生活，还会严重影响患者的生殖健康和生育能力[2]。对于厌氧菌性感染盆腔炎的治疗多采用硝基咪唑类抗生素，临床较为常见用药为甲硝唑、替硝唑和奥硝唑，本次研究奥硝唑治疗厌氧菌感染的盆腔炎患者的临床效果，现进行报道。
1资料与方法
1.1一般资料 本次研究患者资料为本院2014年8月～2015年8月收治的厌氧菌感染性盆腔炎患者150例，患者年龄在20～62岁，平均年龄(43.5±4.3)岁，患者病程为4d～11个月，平均病程(6.51±2.9)个月，两组患者无其他合并症及重要器官的严重疾病。入选患者均符合《妇产科学》盆腔感染的诊断标准，并排除以下患者：未成年患者，妊娠或普如期妇女，合并有严重肝肾功能障碍的患者，在入组研究前已经使用厌氧菌抗生素药物，或对本次研究药物有严重过敏的患者，患者自身意识不清或不愿参加试验的患者，患者在入组前均签署知情同意书并自愿入组参加治疗。根据患者的就诊时间随机分为对照组和观察组，每组75例，其中对照组患者年龄20～60岁，平均年龄(42.3±5.3)岁，病程5 d～10个月，平均病程(6.23±3.2)个月，观察组患者年龄22～57岁，平均年龄(45.3±4.2)岁，病程4 d～11个月，平均病程(5.46±3.2)个月，两组患者的临床资料如年龄、病程、感染情况等一般资料无统计学差异(P>0.05)可进行组间比较。, http://www.100md.com(刘立冬)