头孢甲肟与头孢唑肟治疗胆源性胰腺炎的临床观察(1)
摘要：目的 研究头孢甲肟联与头孢唑肟治疗胆源性胰腺炎的临床疗效及安全性。方法 将60例胆源性胰腺炎患者随机分为治疗组和对照组各30例，两组患者入院分别接受同等剂量(2.0 g)、同等用法(静脉滴注，1次/12h)治疗，对照组给予头孢唑肟钠，治疗组给予头孢甲肟，疗程均为6～15 d，疗程结束后评价两组患者的疗效及不良反应。结果 两组患者经治疗后，治疗组体温恢复正常时间、腹痛缓解时间、转氨酶降至正常时间、血及尿淀粉酶降至正常时间均明显少于对照组，两组比较差异有统计学意义(P<0.05)；两组患者主要不良反应为恶心、呕吐、皮肤发痒等，但两组不良反应发生率差异无统计学意义(P>0.05)，且不良反应大多轻微并为一过性。结论 注射用盐酸头孢甲肟可安全、有效地用于治疗胆源性胰腺炎，值得临床推广。
关键词：头孢甲肟；头孢唑肟；胆源性胰腺炎：临床疗效；不良反应
Clinical Observation of Cefmenoxime and Cefazoxime in the Treatment of Biliary Pancreatitis
, 百拇医药
YANG Zhi-chao，HE Chun-yan
(Department of Gastroenterology，Fuxin Central Hospital，Fuxin 123000，Liaoning，China)
Abstract：Objective To study the clinical efficacy and safety of cefmenoxime combined with ceftizoxime in treatment of biliary pancreatitis.Methods 60 cases of patients with biliary pancreatitis were randomly divided into treatment group and control group of 30 cases，two patients were received the same dose(2.0g)，the same usage(intravenous drip，1 times/12h)treatment，the control group was given ceftizoxime sodium，the treatment group was given cefmenoxime，treatment for 6～15d，curative effect and adverse reaction of two groups of patients with the evaluation after the end of treatment.Results Two groups of patients after treatment，treatment group，body temperature returned to normal time，the abdominal pain time，transaminase decreased to normal time，blood and urine amylase returned to normal time significantly less than the control group，there was significant difference between two groups(P<0.05)；the main adverse reactions of the two groups of patients were nausea，vomiting，skin itching，but the adverse reactions of two groups were not statistically significant(P>0.05)，and the adverse reactions are mild and transient.Conclusion Cefmnoxime Hydrochloride for injection can be safely and effectively used in the treatment of biliary pancreatitis，worthy of promotion.
, http://www.100md.com
Key words：Cefmenoxime；Ceftizoxime；Biliary pancreatitis：Clinical curative effect；Adverse reaction
膽源性胰腺炎(约95%的患者)[1]，常常突发在左上腹或上腹表现出刀割样疼痛或持续性剧痛，且上腹腰部表现出一种束带感，多在饱餐或饮酒后发生，且进食后症状可加重，并放射至脐周甚至全腹痛，若合并胆管结石或胆道蛔虫则有右上腹痛，胆绞痛。常见症状表现为腹痛、恶心呕吐、黄疸、发热等，若出现发热则提示为胰腺感染或脓肿形成，并出现中毒症状，如果不及时控制感染则容易发展为重症急性坏死型胰腺炎，而导致休克、急性呼吸衰竭、急性肾功能衰竭等严重并发症对生命造成威胁。故要降低急性胰腺炎的死亡率，应把重点放在感染上。本研究将表明头孢甲肟治疗胆源性胰腺炎临床疗效，现报道如下：
1 资料与方法
1.1一般资料 本组患者60例随机分为治疗组和对照组各30例。治疗组中男15例，女15例，年龄 34～70岁；对照组中男17例，女13例，年龄35～68岁。所有患者经诊断，符合胆源性胰腺炎标准，患病初期，均有上腹和左上腹疼痛。化验室检查血、尿淀粉酶升高，CT影像学提示有胆源性胰腺炎影像改变。两组患者病程、临床症状及体征、年龄、性别等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(杨智超 何春艳)
关键词：头孢甲肟；头孢唑肟；胆源性胰腺炎：临床疗效；不良反应
Clinical Observation of Cefmenoxime and Cefazoxime in the Treatment of Biliary Pancreatitis
, 百拇医药
YANG Zhi-chao，HE Chun-yan
(Department of Gastroenterology，Fuxin Central Hospital，Fuxin 123000，Liaoning，China)
Abstract：Objective To study the clinical efficacy and safety of cefmenoxime combined with ceftizoxime in treatment of biliary pancreatitis.Methods 60 cases of patients with biliary pancreatitis were randomly divided into treatment group and control group of 30 cases，two patients were received the same dose(2.0g)，the same usage(intravenous drip，1 times/12h)treatment，the control group was given ceftizoxime sodium，the treatment group was given cefmenoxime，treatment for 6～15d，curative effect and adverse reaction of two groups of patients with the evaluation after the end of treatment.Results Two groups of patients after treatment，treatment group，body temperature returned to normal time，the abdominal pain time，transaminase decreased to normal time，blood and urine amylase returned to normal time significantly less than the control group，there was significant difference between two groups(P<0.05)；the main adverse reactions of the two groups of patients were nausea，vomiting，skin itching，but the adverse reactions of two groups were not statistically significant(P>0.05)，and the adverse reactions are mild and transient.Conclusion Cefmnoxime Hydrochloride for injection can be safely and effectively used in the treatment of biliary pancreatitis，worthy of promotion.
, http://www.100md.com
Key words：Cefmenoxime；Ceftizoxime；Biliary pancreatitis：Clinical curative effect；Adverse reaction
膽源性胰腺炎(约95%的患者)[1]，常常突发在左上腹或上腹表现出刀割样疼痛或持续性剧痛，且上腹腰部表现出一种束带感，多在饱餐或饮酒后发生，且进食后症状可加重，并放射至脐周甚至全腹痛，若合并胆管结石或胆道蛔虫则有右上腹痛，胆绞痛。常见症状表现为腹痛、恶心呕吐、黄疸、发热等，若出现发热则提示为胰腺感染或脓肿形成，并出现中毒症状，如果不及时控制感染则容易发展为重症急性坏死型胰腺炎，而导致休克、急性呼吸衰竭、急性肾功能衰竭等严重并发症对生命造成威胁。故要降低急性胰腺炎的死亡率，应把重点放在感染上。本研究将表明头孢甲肟治疗胆源性胰腺炎临床疗效，现报道如下：
1 资料与方法
1.1一般资料 本组患者60例随机分为治疗组和对照组各30例。治疗组中男15例，女15例，年龄 34～70岁；对照组中男17例，女13例，年龄35～68岁。所有患者经诊断，符合胆源性胰腺炎标准，患病初期，均有上腹和左上腹疼痛。化验室检查血、尿淀粉酶升高，CT影像学提示有胆源性胰腺炎影像改变。两组患者病程、临床症状及体征、年龄、性别等一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(杨智超 何春艳)
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