绝经后女性骨质疏松性骨折与骨密度及年龄的相关性分析(1)
摘要:目的 探讨年龄及骨密度与骨质疏松性骨折的相关性。方法 研究对象为我院确诊为绝经后女性骨质疏松患者120例,年龄46~83岁,平均年龄(68.66±9.78)岁。随访1年后,有专门人员收集其一般临床信息包括年龄、身高及体重等及健侧髋部的骨密度值,并进行统计分析。结果 随访1年后,发生骨质疏松性骨折的患者共89例,发生率为16.9%。t检验显示,骨折组平均年龄要高于非骨折组(P<0.05),而其骨密度平均值则低于非骨折组(P<0.05),两组在身高、体重计等方面无显著差异P>0.05。Spearman相关性分析发现,年龄和骨密度与经后女性骨质疏松性骨折显著相关,r值分别为0.361和-0.364,P<0.05。结论 骨量丢失和增龄是绝经后女性骨质疏松性骨折发生的危险因素。
关键词:骨质疏松骨折;骨密度;年龄
Correlation Analysis of Bone Mineral Density and Age in Postmenopausal Women with Osteoporotic Fracture
, 百拇医药
ZHANG Xuan,YANG Meng-xue,ZHANG Ling
(Department of Endocrinology,Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou,China)
Abstract:Objective To investigate the age and bone mineral density and fracture correlation.Methods In our hospital diagnosed 120 cases of female patients with osteoporosis in postmenopausal women,aged 46~83 years old, average age(68.66±9.78)years old.After 1 years of follow-up,with specialized personnel to collect their general clinical information including age,height and bone density the weight of the contralateral hip,and statistical analysis.Results After 1 years of follow-up,a total of 89 cases of osteoporotic fracture patients,the incidence of 16.9%.t test showed that the average age of the fracture group was higher than that of non fracture group(P<0.05),while the average bone density was lower than that of non fracture group(P<0.05), there was no significant difference between the two groups in height,weight and so on.P>0.05.Spearman correlation analysis showed that age and bone density after female osteoporotic fracture was significantly related to the value of r is 0.361 and -0.364 respectively,P<0.05.Conclusion The loss of bone mass and age are the risk factors of osteoporotic fractures in postmenopausal women.
, 百拇医药
Key words:Osteoporotic fracture;Bone mineral density;Age
骨质疏松性骨折又称脆性骨折,是一种因骨量低下、骨的显微结构遭破坏,導致骨脆性增加而容易发生骨折的全身性骨病,主要发生在绝经后女性和老年人群[1]。绝经后骨质疏松症主要是由于绝经后妇女卵巢功能衰退,雌激素水平下降,骨吸收大于骨形成,导致低骨量的形成和骨组织纤维结构退行性变[2]。研究表明,随着年龄的增长尤其是40岁后,骨质疏松症的发病率呈指数增加,且女性的发病率明显高于男性[3]。该病会造成腰背部疼痛、驼背,尤其是骨折及骨折致残致死,严重的影响了中老年妇女的生活质量,为家庭和社会带来了沉重的社会和生活负担。骨密度是目前诊断骨质疏松症,预测其骨折风险,监测自然秉承及评价药物干预疗效的可量化指标,也是最佳指标。其能反映大约70%的股强度。研究表明,低骨密度增加骨折危险性。因此,探讨年龄和骨密度与绝经后女性骨质疏松性骨折的相关性,对预防绝经后女性骨质疏松性骨折具有重要意义。本研究以绝经后骨折疏松女性为研究对象,探讨年龄及骨密度与骨质疏松性骨折的相关性。
1资料与方法
1.1一般资料 研究对象为我院确诊为绝经后女性骨质疏松患者120例,年龄46~83岁,平均年龄(68.66±9.78)岁。入选标准为:停经12月以上,未接受过抗骨质疏松症药物治疗,能接受X线骨密度检查。排出标准为:原发性甲状旁腺功能亢进症、库欣综合征、甲状腺疾病、类风湿关节炎等对骨代谢有明显影响的相关疾病,糖皮质激素、精神类药物、抗凝血药物等相关药物使用史。所有患者均同意参加本研究,并签署之情同意书。, 百拇医药(张旋 杨孟雪 张凌)
关键词:骨质疏松骨折;骨密度;年龄
Correlation Analysis of Bone Mineral Density and Age in Postmenopausal Women with Osteoporotic Fracture
, 百拇医药
ZHANG Xuan,YANG Meng-xue,ZHANG Ling
(Department of Endocrinology,Affiliated Hospital of Zunyi Medical College,Zunyi 563003,Guizhou,China)
Abstract:Objective To investigate the age and bone mineral density and fracture correlation.Methods In our hospital diagnosed 120 cases of female patients with osteoporosis in postmenopausal women,aged 46~83 years old, average age(68.66±9.78)years old.After 1 years of follow-up,with specialized personnel to collect their general clinical information including age,height and bone density the weight of the contralateral hip,and statistical analysis.Results After 1 years of follow-up,a total of 89 cases of osteoporotic fracture patients,the incidence of 16.9%.t test showed that the average age of the fracture group was higher than that of non fracture group(P<0.05),while the average bone density was lower than that of non fracture group(P<0.05), there was no significant difference between the two groups in height,weight and so on.P>0.05.Spearman correlation analysis showed that age and bone density after female osteoporotic fracture was significantly related to the value of r is 0.361 and -0.364 respectively,P<0.05.Conclusion The loss of bone mass and age are the risk factors of osteoporotic fractures in postmenopausal women.
, 百拇医药
Key words:Osteoporotic fracture;Bone mineral density;Age
骨质疏松性骨折又称脆性骨折,是一种因骨量低下、骨的显微结构遭破坏,導致骨脆性增加而容易发生骨折的全身性骨病,主要发生在绝经后女性和老年人群[1]。绝经后骨质疏松症主要是由于绝经后妇女卵巢功能衰退,雌激素水平下降,骨吸收大于骨形成,导致低骨量的形成和骨组织纤维结构退行性变[2]。研究表明,随着年龄的增长尤其是40岁后,骨质疏松症的发病率呈指数增加,且女性的发病率明显高于男性[3]。该病会造成腰背部疼痛、驼背,尤其是骨折及骨折致残致死,严重的影响了中老年妇女的生活质量,为家庭和社会带来了沉重的社会和生活负担。骨密度是目前诊断骨质疏松症,预测其骨折风险,监测自然秉承及评价药物干预疗效的可量化指标,也是最佳指标。其能反映大约70%的股强度。研究表明,低骨密度增加骨折危险性。因此,探讨年龄和骨密度与绝经后女性骨质疏松性骨折的相关性,对预防绝经后女性骨质疏松性骨折具有重要意义。本研究以绝经后骨折疏松女性为研究对象,探讨年龄及骨密度与骨质疏松性骨折的相关性。
1资料与方法
1.1一般资料 研究对象为我院确诊为绝经后女性骨质疏松患者120例,年龄46~83岁,平均年龄(68.66±9.78)岁。入选标准为:停经12月以上,未接受过抗骨质疏松症药物治疗,能接受X线骨密度检查。排出标准为:原发性甲状旁腺功能亢进症、库欣综合征、甲状腺疾病、类风湿关节炎等对骨代谢有明显影响的相关疾病,糖皮质激素、精神类药物、抗凝血药物等相关药物使用史。所有患者均同意参加本研究,并签署之情同意书。, 百拇医药(张旋 杨孟雪 张凌)
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