氟西汀合并抗精神病药物治疗具有强迫症状的精神分裂症的疗效研究(1)
摘要：目的 研究氟西汀合并抗精神病药物治疗具有强迫症状的精神分裂症的疗效。方法 选取我院收治的患有强迫症状的精神分裂患者60例，随机分为对照组和观察组，每组各30例，均采用抗精神病药物治疗，观察组在此基础之上加入氟西汀治疗，治疗1个月后观察对比两组疗效、强迫症状量表(Y-BOCS)等，同时记录不良反应的发生情况。结果 观察组的总有效率显著高于对照组，差异具有统计学意义(P<0.05)。治疗1个月后，治疗组的Y-BOCS评分低于对照组，差异具有统计学意义(P<0.05)。结论 在治疗有强迫症状的精神分裂患者时应用氟西汀联合抗精神病药物，可以有效改善精神分裂患者的强迫症状及精神症状，有助于提高此类患者的生活质量。
关键词：氟西汀；抗精神病药物；强迫症状；精神分裂症
中图分类号：R749.3 文献标识码：A 文章编号：1006-1959(2017)16-0087-02
Efficacy of Fluoxetine in Combination with Antipsychotic Drugs in the Treatment of Schizophrenia with Obsessive Symptoms
, 百拇医药
ZHAO Liang，LUO Yi，TANG Sheng，DU Jie
(Department of Psychiatry，Six Ward，Wuhan Excellent Hospital，Wuhan 430023，Hubei，China)
Abstract：Objective To study the efficacy of fluoxetine combined with antipsychotic treatment of schizophrenia with obsessive-compulsive symptoms. Methods We selected 60 cases of schizophrenic patients with obsessive-compulsive symptoms in our hospital.They were randomly divided into the control group and the observation group，30 cases in each group，all of them were treated with antipsychotic drugs，the observation group was treated with fluoxetine on the basis of this treatment.After 1 month treatment，the curative effect of the two groups and obsessive compulsive disorder scale(Y-BOCS)were observed and compared，and the adverse reactions were recorded.Results The total effective rate of observation group was significantly higher than the control group，the difference was statistically significant(P<0.05).After 1 month of treatment，Y-BOCS score of treatment group was lower than that of the control group，the difference was statistically significant(P<0.05).Conclusion In the treatment of obsessive-compulsive symptoms in patients with schizophrenia by fluoxetine combined with antipsychotic drugs，can effectively improve the patients with schizophrenia and obsessive-compulsive symptoms of psychiatric symptoms，which is helpful to improve the quality of life of patients.
, 百拇医药
Key words：Fluoxetine；Antipsychotic drugs；Obsessive-compulsive symptoms；Schizophrenia
精神分裂癥是一种临床上常见的、严重的精神疾病，它的发病常与遗传学、神经生物学、社会心理学等因素相关。强迫症状的临床发生率为13%～25%，是精神分裂症较为常见的症状之一，在慢性分裂症患者中发生率更高，可发生于精神分裂症的各个阶段[1]。当精神分裂患者出现强迫症状时，不仅会加重病情，并且会进一步增加治疗的难度，严重影响患者生活质量。此类患者临床治疗多采用抗精神病药物单用或联合治疗，虽能在一定程度上改善患者的强迫症状和精神现状，但整体疗效常不理想。氟西汀具有较好的抗强迫、抗抑郁的效果，是一种选择性血清再吸收抑制剂[2-3]。笔者对我院收治的60例精神分裂伴强迫症状患者随机分为对照组和观察组，观察组在一般治疗的基础上给予氟西汀治疗，取得了较好的疗效，现报道如下。
1 资料与方法
1.1一般资料
选取我院收治的精神分裂伴有强迫症状的患者60例，患者均符合《中国精神障碍分类与诊断标准》第3版，关于精神分裂症的诊断标准[4]。随机分为对照组和观察组，每组各30例。男38例，女22例，平均年龄(43.2±3.7)岁，病程8个月～10年，平均(5.1±0.5)年，Y-BOCS评分(20.07±5.87)分。纳入标准：①Y-BOCS评分>8分；②近2 w内未服用抗强迫症状、抗精神病药物；③支持本次研究，并签署知情同意书。排除标准：①严重躯体疾病、脑器质性疾病患者；②药物过敏体质患者；③妊娠期、哺乳期妇女。两组患者年龄、性别等一般资料差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(赵亮 罗毅 唐晟 杜洁)
关键词：氟西汀；抗精神病药物；强迫症状；精神分裂症
中图分类号：R749.3 文献标识码：A 文章编号：1006-1959(2017)16-0087-02
Efficacy of Fluoxetine in Combination with Antipsychotic Drugs in the Treatment of Schizophrenia with Obsessive Symptoms
, 百拇医药
ZHAO Liang，LUO Yi，TANG Sheng，DU Jie
(Department of Psychiatry，Six Ward，Wuhan Excellent Hospital，Wuhan 430023，Hubei，China)
Abstract：Objective To study the efficacy of fluoxetine combined with antipsychotic treatment of schizophrenia with obsessive-compulsive symptoms. Methods We selected 60 cases of schizophrenic patients with obsessive-compulsive symptoms in our hospital.They were randomly divided into the control group and the observation group，30 cases in each group，all of them were treated with antipsychotic drugs，the observation group was treated with fluoxetine on the basis of this treatment.After 1 month treatment，the curative effect of the two groups and obsessive compulsive disorder scale(Y-BOCS)were observed and compared，and the adverse reactions were recorded.Results The total effective rate of observation group was significantly higher than the control group，the difference was statistically significant(P<0.05).After 1 month of treatment，Y-BOCS score of treatment group was lower than that of the control group，the difference was statistically significant(P<0.05).Conclusion In the treatment of obsessive-compulsive symptoms in patients with schizophrenia by fluoxetine combined with antipsychotic drugs，can effectively improve the patients with schizophrenia and obsessive-compulsive symptoms of psychiatric symptoms，which is helpful to improve the quality of life of patients.
, 百拇医药
Key words：Fluoxetine；Antipsychotic drugs；Obsessive-compulsive symptoms；Schizophrenia
精神分裂癥是一种临床上常见的、严重的精神疾病，它的发病常与遗传学、神经生物学、社会心理学等因素相关。强迫症状的临床发生率为13%～25%，是精神分裂症较为常见的症状之一，在慢性分裂症患者中发生率更高，可发生于精神分裂症的各个阶段[1]。当精神分裂患者出现强迫症状时，不仅会加重病情，并且会进一步增加治疗的难度，严重影响患者生活质量。此类患者临床治疗多采用抗精神病药物单用或联合治疗，虽能在一定程度上改善患者的强迫症状和精神现状，但整体疗效常不理想。氟西汀具有较好的抗强迫、抗抑郁的效果，是一种选择性血清再吸收抑制剂[2-3]。笔者对我院收治的60例精神分裂伴强迫症状患者随机分为对照组和观察组，观察组在一般治疗的基础上给予氟西汀治疗，取得了较好的疗效，现报道如下。
1 资料与方法
1.1一般资料
选取我院收治的精神分裂伴有强迫症状的患者60例，患者均符合《中国精神障碍分类与诊断标准》第3版，关于精神分裂症的诊断标准[4]。随机分为对照组和观察组，每组各30例。男38例，女22例，平均年龄(43.2±3.7)岁，病程8个月～10年，平均(5.1±0.5)年，Y-BOCS评分(20.07±5.87)分。纳入标准：①Y-BOCS评分>8分；②近2 w内未服用抗强迫症状、抗精神病药物；③支持本次研究，并签署知情同意书。排除标准：①严重躯体疾病、脑器质性疾病患者；②药物过敏体质患者；③妊娠期、哺乳期妇女。两组患者年龄、性别等一般资料差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(赵亮 罗毅 唐晟 杜洁)
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