精神分裂症患者肝胆彩色多普勒超声结果分析(1)
摘要：目的 探討长期服用抗精神病药物的精神分裂症患者肝胆彩色多普勒超声异常改变情况及影响因素。方法 选取2013年3月～2016年12月在我院住院治疗长期服用抗精神病药物的150例精神分裂症患者和150例健康体检者为研究对象，研究组为精神分裂症患者，对照组为健康体检者，两组均进行肝胆彩色多普勒超声检查，比较两组研究对象肝胆彩色多普勒超声检查阳性率差异，以及比较精神分裂症患者不同用药方式、不同用药时间、不同年龄及不同性别对肝胆彩色多普勒超声检查阳性率的影响。结果 研究组肝胆彩色多普勒超声检查异常77例(51.30%)，对照组异常34例(22.70%)，研究组显著高于对照组(χ2=26.441，P<0.01)，差异具有统计学意义。在研究组中，肝胆彩色多普勒超声检查阳性率比较：联合用药患者高于单一用药患者；用药时间10年以上患者高于3～10年患者；50岁以上患者高于50岁以下患者，差异具有统计学意义(P<0.05)，但男性与女性的肝胆彩色多普勒超声检查阳性率比较，差异无统计学意义(P>0.05)。结论 长期服用抗精神病药物治疗的精神分裂症患者易出现药物性内脏疾病，尤以肝胆显著，联合用药、用药时间10年以上及50岁以上患者可加重抗精神病药物对肝胆功能的损害，因此对这类人群应定期进行肝胆彩色多普勒超声检查以及肝功能等检查，可较早发现肝功能损害程度，及时治疗肝胆系统异常，为临床合理用药提供科学依据。
, 百拇医药
关键词：精神分裂症；抗精神病药；肝胆彩色多普勒超声；阳性率
中图分类号：R749.3 文献标识码：A 文章编号：1006-1959(2017)17-0050-03 Analysis of Hepatobiliary Color Doppler Ultrasonography in Schizophrenia Patients
TANG Yan1，DU Feng2
(Ningxia Civil Affairs Department Minkang Hospital Outpatient Department of Color Ultrasonic Room1，Outpatient Department Radiology2，Yinchuan 750011，Ningxia，China)
Abstract：Objective To investigate the abnormal changes of hepatobiliary color Doppler ultrasonography in schizophrenic patients who took antipsychotic drugs for a long time and the influencing factors.Methods From March 2013 to December 2016，150 patients with schizophrenia and 150 healthy subjects were enrolled in our hospital for long-term use of antipsychotic drugs.The patients in the study group were schizophrenic patients and the control group were healthy subjects.The two groups were examined by hepatobiliary color Doppler ultrasonography，to compare the positive rate of hepatobiliary color Doppler ultrasonography in the two groups，and to compare the effects of different methods of administration，different time，different age and different sex on the positive rate of hepatobiliary color Doppler ultrasonography.Results The study group of hepatobiliary color Doppler ultrasound examination was abnormal in 77 cases(51.30%)，the control group was abnormal in 34 cases(22.70%)，the study group was significantly higher than that of control group(χ2=26.441，P<0.01)，the difference was statistically significant.In the study group，the positive rate of hepatobiliary color Doppler ultrasonography was compared：the patients in the combination group were higher than those in the single drug patients；the patients who had been treated for more than 10 years were higher than the medication patients aged 3 to 10 years；Over 50 years of age were higher than that of patients under the age of 50，the difference was statistically significant(P<0.05)，however，the positive rates of hepatobiliary color Doppler ultrasonography were not statistically different between men and women(P>0.05).Conclusion Patients with schizophrenia who have been treated with antipsychotic drugs for a long time are prone to drug-induced visceral diseases，especially in patients with liver and gallbladder，combined with medication for more than 10 years and over 50 years of age can aggravate the damage of liver and gallbladder function of antipsychotic drugs，so for this population should be regularly hepatobiliary color Doppler ultrasound and liver function examination，liver function damage can be detected early，timely treatment of hepatobiliary abnormalities，and provide scientific basis for clinical rational drug use., http://www.100md.com(唐燕 杜锋)
, 百拇医药
关键词：精神分裂症；抗精神病药；肝胆彩色多普勒超声；阳性率
中图分类号：R749.3 文献标识码：A 文章编号：1006-1959(2017)17-0050-03 Analysis of Hepatobiliary Color Doppler Ultrasonography in Schizophrenia Patients
TANG Yan1，DU Feng2
(Ningxia Civil Affairs Department Minkang Hospital Outpatient Department of Color Ultrasonic Room1，Outpatient Department Radiology2，Yinchuan 750011，Ningxia，China)
Abstract：Objective To investigate the abnormal changes of hepatobiliary color Doppler ultrasonography in schizophrenic patients who took antipsychotic drugs for a long time and the influencing factors.Methods From March 2013 to December 2016，150 patients with schizophrenia and 150 healthy subjects were enrolled in our hospital for long-term use of antipsychotic drugs.The patients in the study group were schizophrenic patients and the control group were healthy subjects.The two groups were examined by hepatobiliary color Doppler ultrasonography，to compare the positive rate of hepatobiliary color Doppler ultrasonography in the two groups，and to compare the effects of different methods of administration，different time，different age and different sex on the positive rate of hepatobiliary color Doppler ultrasonography.Results The study group of hepatobiliary color Doppler ultrasound examination was abnormal in 77 cases(51.30%)，the control group was abnormal in 34 cases(22.70%)，the study group was significantly higher than that of control group(χ2=26.441，P<0.01)，the difference was statistically significant.In the study group，the positive rate of hepatobiliary color Doppler ultrasonography was compared：the patients in the combination group were higher than those in the single drug patients；the patients who had been treated for more than 10 years were higher than the medication patients aged 3 to 10 years；Over 50 years of age were higher than that of patients under the age of 50，the difference was statistically significant(P<0.05)，however，the positive rates of hepatobiliary color Doppler ultrasonography were not statistically different between men and women(P>0.05).Conclusion Patients with schizophrenia who have been treated with antipsychotic drugs for a long time are prone to drug-induced visceral diseases，especially in patients with liver and gallbladder，combined with medication for more than 10 years and over 50 years of age can aggravate the damage of liver and gallbladder function of antipsychotic drugs，so for this population should be regularly hepatobiliary color Doppler ultrasound and liver function examination，liver function damage can be detected early，timely treatment of hepatobiliary abnormalities，and provide scientific basis for clinical rational drug use., http://www.100md.com(唐燕 杜锋)
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