奥美拉唑联合奥曲肽、血凝酶对消化性溃疡急性上消化道出血老年患者的效果研究(1)
摘要：目的 研究消化性溃疡急性上消化道出血老年患者采用奥美拉唑联合奥曲肽、血凝酶治疗的临床效果。方法 临床纳入120例我院2014年8月～2016年8月收治的消化性溃疡急性上消化道出血老年患者作为研究对象。其中60例患者采用奥美拉唑治疗作为对照组，另60例患者在上述基础上联合奥曲肽和血凝酶治疗作为联合组。观察两组患者治疗效果、止血效果以及不良反应情况。结果 联合组治疗总有效率为98.66%，高于对照组的86.67%，P<0.05。联合组不良反应发生率为5.00%，对照组为6.67%，两组对比无差异(P>0.05)。结论 消化性溃疡急性上消化道出血老年患者采用聯合用药治疗效果更佳，止血效果好，不良反应低，值得临床应用及推广。
关键词：消化性溃疡；急性上消化道出血；联合用药
中图分类号：R573.1 文献标识码：A 文章编号：1006-1959(2017)17-0099-02 Effect of Omeprazole Combined with Octreotide and Blood Coagulation Enzyme on Elderly Patients with Peptic Ulcer with Acute Upper Gastrointestinal Bleeding
, 百拇医药
CHENG Dao-li
(Department of Gastroenterology，Jinkouhe District People's Hospital of Leshan City，Leshan 614700，Sichuan，China)
Abstract：Objective To study the clinical effect of omeprazole combined with octreotide and blood coagulation therapy in elderly patients with peptic ulcer with acute upper gastrointestinal bleeding.Methods 120 cases of acute upper gastrointestinal hemorrhage of digestive ulcer treated in our hospital from August 2014 to August 2016 were taken as the research object.Of these，60 patients were treated with omeprazole as a control group，and 60 patients on the basis of the combination of octreotide and coagulation therapy as a combined group.To observe the therapeutic effect of two groups of patients，the hemostatic effect and adverse reactions.Results The total effective rate of the combined group was 98.66%，higher than that of the control group 86.67%，P<0.05.The incidence of side effects was 5.00% in the combined group and 6.67% in the control group，and there was no difference between the two groups(P>0.05).Conclusion Combined use of drugs in elderly patients with peptic ulcer，acute upper gastrointestinal bleeding，better effect，good hemostatic effect and low adverse reaction，it is worthy of clinical application and popularization.
, 百拇医药
Key words：Peptic ulcer；Acute upper gastrointestinal hemorrhage；Drug combination
上消化道出血是临床消化内科常见疾病之一，主要指屈氏韧带以上的消化道出血症状，上消化道出血包括胃、食管、十二指肠、胰腺等部位出血，而胃空肠吻合术后的空肠病变也属于上消化道出血范畴。急性消化道出血是消化系统中常见的危急重症，严重者引起循环衰竭危及患者生命安全[1]。随着我国人口老龄化的加剧，消化道出血发病率显著上升，老年患者身体机能差，免疫系统机能低下，在发生急性上消化道出血时，有严重生命危险，因此老年急性上消化道出血患者的治疗引起医学者的重视，如何更有效的止血成为人们关注的重点，是挽救老年患者的关键[2]。本文为进一步探讨临床上消化道出血老年患者的药物治疗措施，对我院老年患者进行奥美拉唑、奥曲肽和血凝酶联合用药治疗，观察联合用药对老年患者治疗的临床效果，现报道如下。
1 资料与方法
, 百拇医药
1.1一般资料
本次选取120例我院2014年8月～2016年8月收治的消化性溃疡急性上消化道出血老年患者作为研究对象。纳入标准：①经检查和诊断符合消化性溃疡急性上消化道出血诊断标准[3]的患者；②年龄超过60岁的老年患者；③自愿参加本次研究并签字同意的患者。排除标准：①排除凝血功能异常的患者；②排除对本研究药物过敏的患者。根据随机数字表法分为对照组和联合组各60例。对照组中男34例，女26例，年龄60～88岁，平均年龄(73.2±4.4)岁；出血程度：轻度出血32例，中度出血20例，重度出血8例；溃疡类型：胃溃疡22例，十二指肠溃疡38例。联合组中男35例，女25例，年龄60～86岁，平均年龄(72.9±4.3)岁；出血程度：轻度出血30例，中度出血21例，重度出血9例；溃疡类型：胃溃疡24例，十二指肠溃疡36例。两组患者上述资料(性别、年龄、出血程度以及溃疡类型)均无差异，有可比性(P>0.05)。, 百拇医药(程道理)
关键词：消化性溃疡；急性上消化道出血；联合用药
中图分类号：R573.1 文献标识码：A 文章编号：1006-1959(2017)17-0099-02 Effect of Omeprazole Combined with Octreotide and Blood Coagulation Enzyme on Elderly Patients with Peptic Ulcer with Acute Upper Gastrointestinal Bleeding
, 百拇医药
CHENG Dao-li
(Department of Gastroenterology，Jinkouhe District People's Hospital of Leshan City，Leshan 614700，Sichuan，China)
Abstract：Objective To study the clinical effect of omeprazole combined with octreotide and blood coagulation therapy in elderly patients with peptic ulcer with acute upper gastrointestinal bleeding.Methods 120 cases of acute upper gastrointestinal hemorrhage of digestive ulcer treated in our hospital from August 2014 to August 2016 were taken as the research object.Of these，60 patients were treated with omeprazole as a control group，and 60 patients on the basis of the combination of octreotide and coagulation therapy as a combined group.To observe the therapeutic effect of two groups of patients，the hemostatic effect and adverse reactions.Results The total effective rate of the combined group was 98.66%，higher than that of the control group 86.67%，P<0.05.The incidence of side effects was 5.00% in the combined group and 6.67% in the control group，and there was no difference between the two groups(P>0.05).Conclusion Combined use of drugs in elderly patients with peptic ulcer，acute upper gastrointestinal bleeding，better effect，good hemostatic effect and low adverse reaction，it is worthy of clinical application and popularization.
, 百拇医药
Key words：Peptic ulcer；Acute upper gastrointestinal hemorrhage；Drug combination
上消化道出血是临床消化内科常见疾病之一，主要指屈氏韧带以上的消化道出血症状，上消化道出血包括胃、食管、十二指肠、胰腺等部位出血，而胃空肠吻合术后的空肠病变也属于上消化道出血范畴。急性消化道出血是消化系统中常见的危急重症，严重者引起循环衰竭危及患者生命安全[1]。随着我国人口老龄化的加剧，消化道出血发病率显著上升，老年患者身体机能差，免疫系统机能低下，在发生急性上消化道出血时，有严重生命危险，因此老年急性上消化道出血患者的治疗引起医学者的重视，如何更有效的止血成为人们关注的重点，是挽救老年患者的关键[2]。本文为进一步探讨临床上消化道出血老年患者的药物治疗措施，对我院老年患者进行奥美拉唑、奥曲肽和血凝酶联合用药治疗，观察联合用药对老年患者治疗的临床效果，现报道如下。
1 资料与方法
, 百拇医药
1.1一般资料
本次选取120例我院2014年8月～2016年8月收治的消化性溃疡急性上消化道出血老年患者作为研究对象。纳入标准：①经检查和诊断符合消化性溃疡急性上消化道出血诊断标准[3]的患者；②年龄超过60岁的老年患者；③自愿参加本次研究并签字同意的患者。排除标准：①排除凝血功能异常的患者；②排除对本研究药物过敏的患者。根据随机数字表法分为对照组和联合组各60例。对照组中男34例，女26例，年龄60～88岁，平均年龄(73.2±4.4)岁；出血程度：轻度出血32例，中度出血20例，重度出血8例；溃疡类型：胃溃疡22例，十二指肠溃疡38例。联合组中男35例，女25例，年龄60～86岁，平均年龄(72.9±4.3)岁；出血程度：轻度出血30例，中度出血21例，重度出血9例；溃疡类型：胃溃疡24例，十二指肠溃疡36例。两组患者上述资料(性别、年龄、出血程度以及溃疡类型)均无差异，有可比性(P>0.05)。, 百拇医药(程道理)
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