降钙素原对早期诊断新生儿感染性疾病的临床价值(1)
摘要：目的 探討血清降钙素原对早期诊断新生儿感染性疾病的临床应用价值及意义。方法 选取我院新生儿科感染性疾病患儿86例(其中败血症35例、化脓性脑膜炎(简称化脑)17例、感染性肺炎34例)；非感染性疾病25例为对照组；于入院后应用抗生素治疗前，以及抗生素治疗后3～7 d抽取静脉血，检测外周血白细胞(WBC)计数、C-反应蛋白(CRP)、降钙素原(PCT)及白介素-6(IL-6)，比较治疗前后变化。结果 86例感染患儿中，治疗前血清PCT、CRP、IL-6、外周血WBC计数阳性检出率分别为：94.10%、53.40%、67.40%、23.20%，治疗后其阳性率分别为：17.40%、19.80%、14.00%、0.58%；经比较血清PCT、CRP、IL-6、外周血WBC计数治疗前后其阳性率差异有统计学意义(P<0.05)；外周血WBC计数治疗前在败血症组、肺炎组、化脓组、对照组中比较无差异性(P=0.149)，而PCT、CRP、IL-6治疗前在败血症组、肺炎组、化脓组、对照组中比较具有统计学差异(P<0.05)；血清PCT、CRP、IL-6、外周血WBC、细菌培养检测指标中，PCT阳性率最高，在败血症组、肺炎组、化脑组分别为：94.20%、88.20%、94.10%：，明显高于CRP(71.80%、26.40%、76.40%)、IL-6(74.20%、58.80%、76.40%)、外周血WBC计数(34.20%、26.40%、47.00%)、细菌培养(31.40%、5.59%、52.90%)；经比较具有统计学意义(P<0.05)。结论 PCT是早期诊断新生儿细菌感染性疾病的较好检测指标，具有较好临床应用价值。
, 百拇医药
关键词：新生儿；细菌感染；降钙素原
中图分类号：R722.1 文献标识码：A 文章编号：1006-1959(2017)19-0051-03
Clinical Value of Procalcitonin in Early Diagnosis of Neonatal Infectious Diseases
LEI Xian-ming，FANG Rui，CAO Yun-tao
(Department of Neonatology，Affiliated Hospital of Zunyi Medical College，Zunyi 563003，Guizhou，China)
Abstract：Objective To investigate the clinical value of serum procalcitonin in the early diagnosis of neonatal infectious diseases and its significance. Methods Neonatal infectious diseases in our hospital were 86 cases(including 35 cases of sepsis，purulent meningitis(referred to as PM)in 17 cases，34 cases of pneumonia infection)；non infectious diseases in 25 cases as control group；admitted to hospital after antibiotic treatment before and after antibiotic treatment 3-7 days of venous blood， peripheral blood white blood cell count(WBC)，C-reactive protein(CRP)，procalcitonin(PCT)and interleukin -6(IL-6)，compare the changes before and after treatment.Results Among the 86 children infected，the positive rates of PCT，CRP，IL-6 and peripheral blood WBC count before treatment were 94.1%，53.4%，67.4% and 23.2%，respectively.After treatment，the positive rates were 17.4%，19.8%， 14%，0.58%；The comparison of serum PCT，CRP，IL-6，there was a statistically significant difference of positive rate of WBC in peripheral blood before and after treatment(P<0.05)；peripheral blood WBC count before treatment in sepsis group，pneumonia group，septic group，no difference in the control group(P=0.149)，PCT，CRP，IL-6 before treatment sepsis group，pneumonia group，septic group，the control group was statistically difference(P<0.05)；serum PCT， CRP， IL-6，WBC in peripheral blood， bacteria detection index in PCT，the highest positive rate in the sepsis group，pneumonia group，PM group were 94.2%，88.2%，94.1%：， was significantly higher than that of CRP(71.8%，26.4%，76.4%)，IL-6 (74.2%，58.8%，76.4%)，peripheral blood the count of WBC(34.2%，26.4%，47%)，bacterial culture(31.4%，5.59%，52.9%)；the difference was statistically significant(P<0.05).Conclusion PCT is a good predictor of early diagnosis of neonatal bacterial infectious diseases and has good clinical application value., 百拇医药(雷贤明 方蕊 曹云涛)
, 百拇医药
关键词：新生儿；细菌感染；降钙素原
中图分类号：R722.1 文献标识码：A 文章编号：1006-1959(2017)19-0051-03
Clinical Value of Procalcitonin in Early Diagnosis of Neonatal Infectious Diseases
LEI Xian-ming，FANG Rui，CAO Yun-tao
(Department of Neonatology，Affiliated Hospital of Zunyi Medical College，Zunyi 563003，Guizhou，China)
Abstract：Objective To investigate the clinical value of serum procalcitonin in the early diagnosis of neonatal infectious diseases and its significance. Methods Neonatal infectious diseases in our hospital were 86 cases(including 35 cases of sepsis，purulent meningitis(referred to as PM)in 17 cases，34 cases of pneumonia infection)；non infectious diseases in 25 cases as control group；admitted to hospital after antibiotic treatment before and after antibiotic treatment 3-7 days of venous blood， peripheral blood white blood cell count(WBC)，C-reactive protein(CRP)，procalcitonin(PCT)and interleukin -6(IL-6)，compare the changes before and after treatment.Results Among the 86 children infected，the positive rates of PCT，CRP，IL-6 and peripheral blood WBC count before treatment were 94.1%，53.4%，67.4% and 23.2%，respectively.After treatment，the positive rates were 17.4%，19.8%， 14%，0.58%；The comparison of serum PCT，CRP，IL-6，there was a statistically significant difference of positive rate of WBC in peripheral blood before and after treatment(P<0.05)；peripheral blood WBC count before treatment in sepsis group，pneumonia group，septic group，no difference in the control group(P=0.149)，PCT，CRP，IL-6 before treatment sepsis group，pneumonia group，septic group，the control group was statistically difference(P<0.05)；serum PCT， CRP， IL-6，WBC in peripheral blood， bacteria detection index in PCT，the highest positive rate in the sepsis group，pneumonia group，PM group were 94.2%，88.2%，94.1%：， was significantly higher than that of CRP(71.8%，26.4%，76.4%)，IL-6 (74.2%，58.8%，76.4%)，peripheral blood the count of WBC(34.2%，26.4%，47%)，bacterial culture(31.4%，5.59%，52.9%)；the difference was statistically significant(P<0.05).Conclusion PCT is a good predictor of early diagnosis of neonatal bacterial infectious diseases and has good clinical application value., 百拇医药(雷贤明 方蕊 曹云涛)
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