粉防己碱在减轻深Ⅱ°烧伤创面早期加深效果的初步实验研究(1)
摘要：目的 初步探讨粉防己碱在减轻深Ⅱ°烧伤创面早期加深中的效果。方法 選健康新西兰大白兔20只，体重(2.50±0.30)kg，采用铜梳烫伤法在其背腹部两侧进行深Ⅱ°烧伤动物造模，共4处，将4处创面随时分为4组，每组20个部位，分别对4组创面给予5、25、50 g/L的粉防己碱与面霜基质(对照)外用，换药1次/d，每日观察创面变化并拍照计算间隙正常皮肤的宽度，3 d后处死动物并取创面组织行病理组织学检查，统计Ⅲ°创面个数，并对数据进行统计、分析。结果 对照组伤后24 h间隙区可见大量瘀斑，部分区域坏死，48 h坏死面积增大，72 h进一步扩大，部分与烧伤区域融合。实验组大致无明显差异，伤后24 h间隙区可见少量瘀斑，48 h时瘀滞区局部坏死，72 h时较前局部扩大，未见与烧伤区域融合情况发生。与对照组相比，实验各组均有统计学意义(P<0.05)，在实验组内，72 h时5 g/L组健康创面面积(39.67±4.29)mm2明显低于25 g/L组的(48.52±1.27)mm2(P<0.05)。而72 h加深的创面中25g/L明显低于5 g/L与对照组(P<0.05)。结论 小剂量粉防己碱一定程度上能减轻深Ⅱ°烧伤创面早期加深。
, 百拇医药
关键词：深Ⅱ°烧伤；创面加深；粉防己碱
中图分类号：R644 文献标识码：A 文章编号：1006-1959(2017)19-0056-03
Preliminary Experimental Study on the Effect of Tetrandrine on Deepening Deep Ⅱ° Burn Wounds
ZHANG You-lai，WANG Xiao，DENG Ru-fei，LAI Qing-hong，XIN Guo-hua
(Department of Burns，the First Affiliated Hospital of Nanchang University，Nanchang 330006，Jiangxi，China)
, 百拇医药
Abstract：Objective To investigate the effect of tetrandrine on the deepening of deep Ⅱ° burn wounds.Methods 20 healthy New Zealand white rabbits， weight(2.50±0.30)kg，using copper comb burn method at the back of the abdomen on both sides of deep second degree burn animal model，a total of 4，4 wounds were divided into 4 groups at any time，20 parts of each group，4 groups of wounds were given 5，25，50g/L powder of tetrandrine and cream matrix(control)external use，change dressings 1 times/d，observe the wound changes every day，and take pictures to calculate the width of the normal skin of the gap，3 d after the death of animal and wound tissues were obtained for pathological examination，the statistical number of third Ⅲ° wounds，and the data were statistically analyzed.Results In the control group，24 h after injury in the gap area shows a large number of ecchymosis，necrosis in some areas，necrotic area increased at 48 h，enlarged at 72 h，and partially fused with burn area.There was no significant difference in the experimental group，and a small amount of ecchymosis was observed at 24 h after injury.The local necrosis of the stasis area at 48 h was enlarged at 72 h，and there was no fusion with the burned area.Compared with the control group，the experimental area was statistically significant (P<0.05).In the experimental group，the healthy wound area(39.67±4.29)mm2 in the 5 g/L group was significantly lower than that in the 25 g/L group (48.52±1.27)mm2(P<0.05)at 72 h.The 25g/L in 72 h deepened wound was significantly lower than that in 5 g/L and control group(P<0.05).Conclusion Low dose of tetrandrine can alleviate the deepening of deep Ⅱ° burn wounds., 百拇医药(张友来 王晓 邓如非 赖青鸿 辛国华)
, 百拇医药
关键词：深Ⅱ°烧伤；创面加深；粉防己碱
中图分类号：R644 文献标识码：A 文章编号：1006-1959(2017)19-0056-03
Preliminary Experimental Study on the Effect of Tetrandrine on Deepening Deep Ⅱ° Burn Wounds
ZHANG You-lai，WANG Xiao，DENG Ru-fei，LAI Qing-hong，XIN Guo-hua
(Department of Burns，the First Affiliated Hospital of Nanchang University，Nanchang 330006，Jiangxi，China)
, 百拇医药
Abstract：Objective To investigate the effect of tetrandrine on the deepening of deep Ⅱ° burn wounds.Methods 20 healthy New Zealand white rabbits， weight(2.50±0.30)kg，using copper comb burn method at the back of the abdomen on both sides of deep second degree burn animal model，a total of 4，4 wounds were divided into 4 groups at any time，20 parts of each group，4 groups of wounds were given 5，25，50g/L powder of tetrandrine and cream matrix(control)external use，change dressings 1 times/d，observe the wound changes every day，and take pictures to calculate the width of the normal skin of the gap，3 d after the death of animal and wound tissues were obtained for pathological examination，the statistical number of third Ⅲ° wounds，and the data were statistically analyzed.Results In the control group，24 h after injury in the gap area shows a large number of ecchymosis，necrosis in some areas，necrotic area increased at 48 h，enlarged at 72 h，and partially fused with burn area.There was no significant difference in the experimental group，and a small amount of ecchymosis was observed at 24 h after injury.The local necrosis of the stasis area at 48 h was enlarged at 72 h，and there was no fusion with the burned area.Compared with the control group，the experimental area was statistically significant (P<0.05).In the experimental group，the healthy wound area(39.67±4.29)mm2 in the 5 g/L group was significantly lower than that in the 25 g/L group (48.52±1.27)mm2(P<0.05)at 72 h.The 25g/L in 72 h deepened wound was significantly lower than that in 5 g/L and control group(P<0.05).Conclusion Low dose of tetrandrine can alleviate the deepening of deep Ⅱ° burn wounds., 百拇医药(张友来 王晓 邓如非 赖青鸿 辛国华)
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