乌拉坦对实验家兔三种手术方式麻醉效果的比较研究(1)
摘要：目的 本实验旨在观察乌拉坦(氨基甲酸乙酯)对实验家兔蚓突切除术、胃造瘘术、气管插管术三种手术方式中麻醉效能的影响，进而评价其在实验教学中实验动物麻醉的应用。方法 选择健康实验家兔24只，分三组，每组分别经耳缘静脉缓慢推注乌拉坦(20%，4 ml/kg)，麻醉满意后A组实施家兔蚓突切除术，B组实施胃造瘘术，C组实施气管插管术，分别记录呼吸频率、心率、麻醉起效时间、麻醉维持时间、麻醉苏醒时间，并对麻醉起效时间、维持时间和苏醒时间进行统计学分析。结果 蚓突切除术组、气管插管术组、胃造瘘术麻醉起效时间分别为(6.4±0.8)min，(9.0±0.6)min，(7.7±0.3)min；麻醉维持时间分别为(32±3.7)min，(35±3.9)min，(40±6.5)min；术后苏醒时间依次为(25±3.7)min，(22±3.9)min，(13±6.4)min。结论 20%乌拉坦的麻醉维持时间长，术后死亡率高，适用于实验要求不高，术后要对动物进行处死的动物实验，乌拉坦对于蚓突切除、胃造瘘等开腹手术麻醉维持时间短，术后苏醒时间长，对于气管插管等非开腹手术麻醉维持时间长，术后苏醒时间较短。
, http://www.100md.com
关键词：麻醉；乌拉坦；蚓突切除术；气管切开术；胃造瘘术
中图分类号：R-332 文献标识码：A 文章编号：1006-1959(2017)20-0046-02
Abstract：Objective The purpose of this experiment was to observe the urethane(ethyl carbamate)on experimental rabbit appendix resection， gastrostomy，anesthesia effects of three surgical methods for tracheal intubation，and to evaluate the application of anesthesia in experimental teaching of experimental animal.Methods 24 rabbits were divided into three groups，each group by intravenously urethane(20%，4 ml/kg)，A group received anesthesia satisfaction after resection of fistula in the appendix，B group received gastrostomy，tracheal intubation was performed in C group，respiratory rate，heart rate，time of onset of anesthesia，maintenance time of anesthesia and time of anesthesia recovery were recorded，and the onset time， maintenance time and recovery time of anesthesia were statistically analyzed.Results The appendix resection group，tracheal intubation group， gastrostomy onset time of anesthesia were(6.4±0.8)min，(9.0±0.6)min，(7.7±0.3)min；anesthesia time was(32±3.7)min，(35±3.9)min，(40±6.5)min； postoperative recovery time was(25±3.7)min，(22±3.9)min，(13±6.4)min.Conclusion 20% urethane anesthesia maintained for a long time，postoperative mortality rate is high， suitable for the experimental requirements is not high， Animals were sacrificed after the animal experiments，urethane for earthworm resection，gastric fistula and other open surgery anesthesia to maintain a short time，postoperative recovery time is long，for tracheal intubation and other non-open surgery anesthesia to maintain a long time，postoperative awakening time is shorter.
, 百拇医药
Key words：Anesthesia；Urethane；Earthworm resection；Tracheotomy；Gastrostomy
醫学院校在日常教学中有许多动物实验，家兔是实验中最常用的动物。麻醉是动物实验中至关重要的一个环节[1]，麻醉过浅会使动物遭受过多的痛苦、影响实验进程和实验结果；麻醉过深，轻者影响实验进程、重者可导致实验动物死亡，严重影响实验结果，浪费时间和精力[2]。麻醉药物的选择至关重要，目前，各大院校在学生动物实验教学中经常使用乌拉坦作为麻醉药物，但乌拉坦麻醉对家兔各项生理功能的影响的相关报道较少，本文旨在观察乌拉坦(氨基甲酸乙酯)对实验家兔蚓突切除术、胃造瘘术、气管插管术三种手术方式中麻醉效能的影响，进而评价其在实验教学中实验动物麻醉的应用，以指导科研人员和在校学生很好地对实验动物进行满意的麻醉[3]。, http://www.100md.com(孟永亮 孙彦)
, http://www.100md.com
关键词：麻醉；乌拉坦；蚓突切除术；气管切开术；胃造瘘术
中图分类号：R-332 文献标识码：A 文章编号：1006-1959(2017)20-0046-02
Abstract：Objective The purpose of this experiment was to observe the urethane(ethyl carbamate)on experimental rabbit appendix resection， gastrostomy，anesthesia effects of three surgical methods for tracheal intubation，and to evaluate the application of anesthesia in experimental teaching of experimental animal.Methods 24 rabbits were divided into three groups，each group by intravenously urethane(20%，4 ml/kg)，A group received anesthesia satisfaction after resection of fistula in the appendix，B group received gastrostomy，tracheal intubation was performed in C group，respiratory rate，heart rate，time of onset of anesthesia，maintenance time of anesthesia and time of anesthesia recovery were recorded，and the onset time， maintenance time and recovery time of anesthesia were statistically analyzed.Results The appendix resection group，tracheal intubation group， gastrostomy onset time of anesthesia were(6.4±0.8)min，(9.0±0.6)min，(7.7±0.3)min；anesthesia time was(32±3.7)min，(35±3.9)min，(40±6.5)min； postoperative recovery time was(25±3.7)min，(22±3.9)min，(13±6.4)min.Conclusion 20% urethane anesthesia maintained for a long time，postoperative mortality rate is high， suitable for the experimental requirements is not high， Animals were sacrificed after the animal experiments，urethane for earthworm resection，gastric fistula and other open surgery anesthesia to maintain a short time，postoperative recovery time is long，for tracheal intubation and other non-open surgery anesthesia to maintain a long time，postoperative awakening time is shorter.
, 百拇医药
Key words：Anesthesia；Urethane；Earthworm resection；Tracheotomy；Gastrostomy
醫学院校在日常教学中有许多动物实验，家兔是实验中最常用的动物。麻醉是动物实验中至关重要的一个环节[1]，麻醉过浅会使动物遭受过多的痛苦、影响实验进程和实验结果；麻醉过深，轻者影响实验进程、重者可导致实验动物死亡，严重影响实验结果，浪费时间和精力[2]。麻醉药物的选择至关重要，目前，各大院校在学生动物实验教学中经常使用乌拉坦作为麻醉药物，但乌拉坦麻醉对家兔各项生理功能的影响的相关报道较少，本文旨在观察乌拉坦(氨基甲酸乙酯)对实验家兔蚓突切除术、胃造瘘术、气管插管术三种手术方式中麻醉效能的影响，进而评价其在实验教学中实验动物麻醉的应用，以指导科研人员和在校学生很好地对实验动物进行满意的麻醉[3]。, http://www.100md.com(孟永亮 孙彦)