帕立骨化醇对糖尿病肾病大鼠尿液Podocalyxin水平的影响(3)
综上所述，糖尿病肾病大鼠会出现蛋白尿，蛋白尿是引起肾功能减退的重要原因，帕立骨化醇可以减轻肾小球PCX蛋白的损伤，从而改善糖尿病肾病大鼠蛋白尿的，改善肾脏功能，延缓糖尿病肾病的发展，给临床上糖尿病肾病的治疗提供了新思路。
参考文献：
[1]Tuncdemir M，Ozturk M.The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy[J].Acta Histochem，2010(12)：234-241.
[2]Li C.Vitamin D and diabetic nephropathy[J].Curr Diab Rep，2008(8)：464-469.
, 百拇医药
[3]Chen J，Cui W，Zhang Q，et al.Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial mesenchymal transition and fibrotic processes[J].Am J Transl Res，2015，7(9)：1553-1563.
[4]安明，张瑞霞.早期糖尿病肾病相关危险因素分析[J].医学信息，2016，29(22)：282.
[5]Valdivielso JM，Cannata-Andía J，Coll B，et al.A new role for vitamin D receptor activation in chronic kidney disease[J].Am J Physiol Renal Physiol，2012，297(6)：1502-1509.
, http://www.100md.com
[6]Wang Y，Deb DK，Zhang Z，et al.Vitamin D receptor signaling in podocytes protects against diabetic nephropathy[J].J Am Soc Nephrol，2012，23(2)：1977-1986.
[7]Zhang Y，Ma KL，Liu J，et al.Dysregulation of low-density lipoprotein receptor contributes to podocyte injuries in diabetic nephropathy[J].Am J Physiol Endocrinol Metab，2015，308(12)：1140-1148.
[8]Li YC.Vitamin D regulation of the renin-angiotensin system[J].J Cell Biochem，2013(88)：327-331.
, 百拇医药
[9]Sugimoto Y，Inazumi T，Tsuchiya S.Roles of prostaglandin receptors in female reproduction[J].J Biochem，2015，157(2)：73-80.
[10]Friis U G，Madsen K，Stubbe J，et al.Regulation of renin secretion by renal juxtaglomeru- lar cells[J].PflugersArch，2013，465(1)：25-37.
[11]Yan C L.Renoprotective effects of vitamin D analogs[J].Kidney International，2010，78 (2)：134.
[12]Wang XM，Yao M，Liu SX，et al.Interplay between the Notch and P13KAkt pathways in high glucose induced podocyte apoptosis[J].Am J Physiol Renal Physiol，2014，30(6)：205-213.
, 百拇医药
[13]Tian Y，Lv G，Yang Y，et al.Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats[J].Int J Clin Exp Pathol，2014，7(6)：3028-3037.
[14]Wolf G，Chen S，Ziyadeh FN.From the periphery of the glomerular capillary wall toward the center of disease：podocyte injury comes of age in diabetic nephropathy[J].Diabetes，2005，25(6)：1626-1634.
[15]De Boer IH，Sachs M，Hoofnagle AN，et al.Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease[J].Kidney Int，2013，83(2)：323-330.
編辑/李桦, http://www.100md.com(兰凯 张光伟 秦迎霞 倪菁)
参考文献：
[1]Tuncdemir M，Ozturk M.The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy[J].Acta Histochem，2010(12)：234-241.
[2]Li C.Vitamin D and diabetic nephropathy[J].Curr Diab Rep，2008(8)：464-469.
, 百拇医药
[3]Chen J，Cui W，Zhang Q，et al.Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial mesenchymal transition and fibrotic processes[J].Am J Transl Res，2015，7(9)：1553-1563.
[4]安明，张瑞霞.早期糖尿病肾病相关危险因素分析[J].医学信息，2016，29(22)：282.
[5]Valdivielso JM，Cannata-Andía J，Coll B，et al.A new role for vitamin D receptor activation in chronic kidney disease[J].Am J Physiol Renal Physiol，2012，297(6)：1502-1509.
, http://www.100md.com
[6]Wang Y，Deb DK，Zhang Z，et al.Vitamin D receptor signaling in podocytes protects against diabetic nephropathy[J].J Am Soc Nephrol，2012，23(2)：1977-1986.
[7]Zhang Y，Ma KL，Liu J，et al.Dysregulation of low-density lipoprotein receptor contributes to podocyte injuries in diabetic nephropathy[J].Am J Physiol Endocrinol Metab，2015，308(12)：1140-1148.
[8]Li YC.Vitamin D regulation of the renin-angiotensin system[J].J Cell Biochem，2013(88)：327-331.
, 百拇医药
[9]Sugimoto Y，Inazumi T，Tsuchiya S.Roles of prostaglandin receptors in female reproduction[J].J Biochem，2015，157(2)：73-80.
[10]Friis U G，Madsen K，Stubbe J，et al.Regulation of renin secretion by renal juxtaglomeru- lar cells[J].PflugersArch，2013，465(1)：25-37.
[11]Yan C L.Renoprotective effects of vitamin D analogs[J].Kidney International，2010，78 (2)：134.
[12]Wang XM，Yao M，Liu SX，et al.Interplay between the Notch and P13KAkt pathways in high glucose induced podocyte apoptosis[J].Am J Physiol Renal Physiol，2014，30(6)：205-213.
, 百拇医药
[13]Tian Y，Lv G，Yang Y，et al.Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats[J].Int J Clin Exp Pathol，2014，7(6)：3028-3037.
[14]Wolf G，Chen S，Ziyadeh FN.From the periphery of the glomerular capillary wall toward the center of disease：podocyte injury comes of age in diabetic nephropathy[J].Diabetes，2005，25(6)：1626-1634.
[15]De Boer IH，Sachs M，Hoofnagle AN，et al.Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease[J].Kidney Int，2013，83(2)：323-330.
編辑/李桦, http://www.100md.com(兰凯 张光伟 秦迎霞 倪菁)
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