高强度聚焦超声联合GnRH—a治疗子宫腺肌病的疗效研究(1)
摘要：目的 探究高强度聚焦超声联合GnRH-a治疗子宫腺肌病的疗效。方法 选择我院56例子宫腺肌病患者作为研究对象，按治疗方式的不同将其分成对照组和治疗组，每组28例。对照组患者采用GnRH-a治疗，治疗组患者采用高强度聚焦超声联合GnRH-a治疗，比较两组患者治疗前后的月经量、痛经视觉模拟评分(VAS)、癌抗原、病灶体积、血红蛋白水平、子宫肌瘤大小等变化情况。结果 两组患者的月经量、痛经视觉模拟评分、癌抗原、病灶体积、血红蛋白水平、子宫肌瘤大小在治疗前无明显差异(P>0.05)；采取相应的治疗措施后，治疗组患者的月经量、病灶体积、痛经视觉模拟评分、子宫肌瘤大小均明显小于对照组，治疗组患者的血红蛋白水平明显大于对照组，两组对比差异显著(P<0.05)。结论 采用高强度聚焦超声联合GnRH-a对子宫腺肌病患者进行治疗，不仅能缩小病灶体积和子宫肌瘤大小，并且还能有效改善患者的痛经症状和提升其机体的血红蛋白水平。
关键词：高强度聚焦超声；GnRH-a；子宫腺肌
, 百拇医药 中图分类号：R711.71；R445.1 文献标识码：A 文章编号：1006-1959(2017)26-0170-03
Abstract：Objective To explore the curative effect of high intensity focused ultrasound combined with GnRH-a in the treatment of adenomyosis. Methods In our hospital 56 cases of adenomyosis patients as the research object，according to the different treatment，divided into control group and treatment group，28 cases in each group.The control group was treated with GnRH-a therapy，the treatment group were treated by high intensity focused ultrasound combined with GnRH-a treatment，menstrual volume of two groups were compared before and after treatment，dysmenorrhea，visual analogue scale(VAS)，cancer antigen，tumor volume，hemoglobin levels，changes in the size of uterine fibroids.Results Menstruation of the two groups of patients， pain visual analogue scale，cancer antigen，tumor volume，hemoglobin levels，no significant difference in the size of uterine fibroids before treatment(P> 0.05)；take corresponding treatment measures after menstruation，treatment group patients with dysmenorrhea lesion volume，visual analogue scale，the size of uterine fibroids were significantly less than the control group，the level of hemoglobin of patients in the treatment group higher than the control group， significant differences between two groups(P<0.05).Conclusion High intensity focused ultrasound combined with GnRH-a in the treatment of adenomyosis patients can not only reduce the volume of the lesions and the size of uterine fibroids，but also can effectively improve the dysmenorrhea symptoms and enhance the hemoglobin level of the patients.
, 百拇医药
Key words：High intensity focused ultrasound；GnRH-a；Adenomyosis
子宮腺肌病属于子宫内膜异位症，多发于流产次数较多青年女性和40岁以上的经产妇，该疾病虽属良性病变范畴，但其亦有类似肿瘤的生物学行为且存在浸润生长，并且其还会引发患者出现痛经、月经不调、导致不孕等症状，对患者的生活和工作产生了严重的影响[1]。临床常采用GnRH-a(促性腺激素释放激素激动剂)对患者进行治疗，其能降低患者的雌性激素分泌水平，促使子宫内膜萎缩，从而达到改善患者临床症状的目的，但是单一的药物治疗效果并不是十分理想。因此，临床现已逐步将GnRH-a与高强度聚合超声联合使用，两种治疗方式联合使用，具有良好的治疗效果[2-5]。本文主要探究了高强度聚焦超声联合GnRH-a治疗子宫腺肌病的疗效，现报告如下。
1资料与方法
1.1一般资料
选取我院自2016年2月～2017年2月收治的56例子宫腺肌病患者作为研究对象，患者均符合子宫腺肌病症临床诊断标准，治疗前患者均签署知情同意书，所有程序经过医院伦理委员会审核，按治疗方式的不同将其分成对照组和治疗组，每组28例，对照组患者年龄26～47岁，平均年龄(42.4±1.7)岁；治疗组患者年龄24～48岁，平均年龄(43.2±1.5)岁。两组患者的病灶特点、肌瘤大小无显著差异(P>0.05)。, http://www.100md.com(周玉珍)
关键词：高强度聚焦超声；GnRH-a；子宫腺肌
, 百拇医药 中图分类号：R711.71；R445.1 文献标识码：A 文章编号：1006-1959(2017)26-0170-03
Abstract：Objective To explore the curative effect of high intensity focused ultrasound combined with GnRH-a in the treatment of adenomyosis. Methods In our hospital 56 cases of adenomyosis patients as the research object，according to the different treatment，divided into control group and treatment group，28 cases in each group.The control group was treated with GnRH-a therapy，the treatment group were treated by high intensity focused ultrasound combined with GnRH-a treatment，menstrual volume of two groups were compared before and after treatment，dysmenorrhea，visual analogue scale(VAS)，cancer antigen，tumor volume，hemoglobin levels，changes in the size of uterine fibroids.Results Menstruation of the two groups of patients， pain visual analogue scale，cancer antigen，tumor volume，hemoglobin levels，no significant difference in the size of uterine fibroids before treatment(P> 0.05)；take corresponding treatment measures after menstruation，treatment group patients with dysmenorrhea lesion volume，visual analogue scale，the size of uterine fibroids were significantly less than the control group，the level of hemoglobin of patients in the treatment group higher than the control group， significant differences between two groups(P<0.05).Conclusion High intensity focused ultrasound combined with GnRH-a in the treatment of adenomyosis patients can not only reduce the volume of the lesions and the size of uterine fibroids，but also can effectively improve the dysmenorrhea symptoms and enhance the hemoglobin level of the patients.
, 百拇医药
Key words：High intensity focused ultrasound；GnRH-a；Adenomyosis
子宮腺肌病属于子宫内膜异位症，多发于流产次数较多青年女性和40岁以上的经产妇，该疾病虽属良性病变范畴，但其亦有类似肿瘤的生物学行为且存在浸润生长，并且其还会引发患者出现痛经、月经不调、导致不孕等症状，对患者的生活和工作产生了严重的影响[1]。临床常采用GnRH-a(促性腺激素释放激素激动剂)对患者进行治疗，其能降低患者的雌性激素分泌水平，促使子宫内膜萎缩，从而达到改善患者临床症状的目的，但是单一的药物治疗效果并不是十分理想。因此，临床现已逐步将GnRH-a与高强度聚合超声联合使用，两种治疗方式联合使用，具有良好的治疗效果[2-5]。本文主要探究了高强度聚焦超声联合GnRH-a治疗子宫腺肌病的疗效，现报告如下。
1资料与方法
1.1一般资料
选取我院自2016年2月～2017年2月收治的56例子宫腺肌病患者作为研究对象，患者均符合子宫腺肌病症临床诊断标准，治疗前患者均签署知情同意书，所有程序经过医院伦理委员会审核，按治疗方式的不同将其分成对照组和治疗组，每组28例，对照组患者年龄26～47岁，平均年龄(42.4±1.7)岁；治疗组患者年龄24～48岁，平均年龄(43.2±1.5)岁。两组患者的病灶特点、肌瘤大小无显著差异(P>0.05)。, http://www.100md.com(周玉珍)
参见：首页 > 医疗版 > 疾病专题 > 妇产科 > 子宫腺肌病