BNP对CRT后期疗效的临床评价(1)
摘 要：目的 观察B-型脑钠肽(brain natriuretic peptide，BNP)对心脏再同步化起搏器治疗慢性心功能不全(chronic heart failure，CHF)的临床评价。方法 选择2010年3月～2017年1月于我院顺利完成心脏再同步化治疗的慢性心功能不全患者46例。在治疗前及治疗后6个月，对患者进行NYHA分级标准评估，通过采取心脏超声来对相应患者的LVEF(左室射血分数)， LVESVI(左室收缩末期容量指数)相关指数进行评价，并且采取酶联免疫法(Enzyme-linked immunosorbent assay， ELISA)测定研究对象手术前后BNP的表达水平，随后运用统计学软件分析检验结果。结果 终点观察达到6个月，研究对象LVEF， LVESVI及心脏功能NYHA分级标准均较治疗前明显表达上调，且有统计学差异(P<0.05)；患者BNP的浓度较治疗前显著降低，且有统计学差异(P<0.05)。结论 CRT明显改善慢性心衰的心功能，通过检测患者BNP水平可对其做出有效评价。
关键词：心力衰竭；心脏再同步化治疗；心脏功能；BNP；超声心动描记术
, http://www.100md.com
中图分类号：R541 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.024
文章编号：1006-1959(2018)01-0067-03
Clinical Evaluation of BNP in Treatment of Late CRT
GUO Jun-lin1，ZHANG li2
(1.Guang'an People's Hospital of Sichuan Province/Guang'an Hospital of West China，Sichuan University，Guang'an 638000，Sichuan，China；
2.Department of Cardiology，West China Hospital，Sichuan University，Chengdu 610041，Sichuan，China)
, 百拇医药
Abstract：Objective To observe the clinical evaluation of B-brain natriuretic peptide(BNP)in the treatment of chronic cardiac insufficiency (chronic heart failure)with cardiac cardiac(cardiac resynchronization therapy).Methods From March 2010～2017 year in January in our hospital，the successful completion of cardiac resynchronization therapy of the patients with chronic heart failure in 46 cases.In 6 months before and after treatment，the patients were evaluated by NYHA grading standards，LVEF(LVEF)and LVESVI(relative index of left ventricular end-systolic index)of the corresponding patients were evaluated by using echocardiography.Enzyme-linked immunosorbent assay(ELISA)BNP expression level before and after surgery， and then use the statistical software analysis of test results.Results The end point of observation reached 6 months， the study objects LVEF，LVESVI and cardiac function NYHA grade were significantly higher than the treatment of expression，and there was a significant difference(P<0.05)；patients with BNP concentrations were significantly lower than before treatment，and statistically difference(P<0.05). Conclusion CRT significantly improves cardiac function in patients with chronic heart failure，which can be effectively assessed by measuring BNP levels in patients.
, 百拇医药
Key words：Heart failure；Cardiac resynchronization therapy；Cardiac function；BNP；Echocardiography
心臟再同步治疗(cardiac resynchronization therapy，CRT)是目前临床中治疗宽QRS波群充血性心力衰竭患者的有效方式之一，现已成为药物难治性心力衰竭的重要治疗方式[1]。CRT能够显著提高心功能，改善生活质量和运动耐量，与此同时CRT也能够明显逆转左室重构，降低心衰患者再住院率和病死率[2]。采用有效的方式对CRT心衰患者术后疗效评估非常重要，临床常采用的评价标准是CRT术后6 y左心室收缩末期容积(LVESV)的减少，术后临床症状、心功等的改善情况[3]。除此之外，某些临床研究采用患者生化学指标的变化来评价CRT临床疗效。根据我院46例成功植入CRT患者随访资料，探讨BNP对其评价价值。, 百拇医药(郭俊林 张立)
关键词：心力衰竭；心脏再同步化治疗；心脏功能；BNP；超声心动描记术
, http://www.100md.com
中图分类号：R541 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.024
文章编号：1006-1959(2018)01-0067-03
Clinical Evaluation of BNP in Treatment of Late CRT
GUO Jun-lin1，ZHANG li2
(1.Guang'an People's Hospital of Sichuan Province/Guang'an Hospital of West China，Sichuan University，Guang'an 638000，Sichuan，China；
2.Department of Cardiology，West China Hospital，Sichuan University，Chengdu 610041，Sichuan，China)
, 百拇医药
Abstract：Objective To observe the clinical evaluation of B-brain natriuretic peptide(BNP)in the treatment of chronic cardiac insufficiency (chronic heart failure)with cardiac cardiac(cardiac resynchronization therapy).Methods From March 2010～2017 year in January in our hospital，the successful completion of cardiac resynchronization therapy of the patients with chronic heart failure in 46 cases.In 6 months before and after treatment，the patients were evaluated by NYHA grading standards，LVEF(LVEF)and LVESVI(relative index of left ventricular end-systolic index)of the corresponding patients were evaluated by using echocardiography.Enzyme-linked immunosorbent assay(ELISA)BNP expression level before and after surgery， and then use the statistical software analysis of test results.Results The end point of observation reached 6 months， the study objects LVEF，LVESVI and cardiac function NYHA grade were significantly higher than the treatment of expression，and there was a significant difference(P<0.05)；patients with BNP concentrations were significantly lower than before treatment，and statistically difference(P<0.05). Conclusion CRT significantly improves cardiac function in patients with chronic heart failure，which can be effectively assessed by measuring BNP levels in patients.
, 百拇医药
Key words：Heart failure；Cardiac resynchronization therapy；Cardiac function；BNP；Echocardiography
心臟再同步治疗(cardiac resynchronization therapy，CRT)是目前临床中治疗宽QRS波群充血性心力衰竭患者的有效方式之一，现已成为药物难治性心力衰竭的重要治疗方式[1]。CRT能够显著提高心功能，改善生活质量和运动耐量，与此同时CRT也能够明显逆转左室重构，降低心衰患者再住院率和病死率[2]。采用有效的方式对CRT心衰患者术后疗效评估非常重要，临床常采用的评价标准是CRT术后6 y左心室收缩末期容积(LVESV)的减少，术后临床症状、心功等的改善情况[3]。除此之外，某些临床研究采用患者生化学指标的变化来评价CRT临床疗效。根据我院46例成功植入CRT患者随访资料，探讨BNP对其评价价值。, 百拇医药(郭俊林 张立)