奥氮平治疗老年痴呆伴精神行为障碍的临床疗效观察(1)
摘 要：目的 观察奥氮平改善老年痴呆精神行为障碍的效果及不良反应情况，评价其临床疗效。方法 将我院2015年2月～2016年10月收治的100例老年痴呆伴精神行为障碍的患者作为观察对象，按入院顺序随机分组，观察组患者采用奥氮平治疗，对照组患者采用利培酮治疗，对比两组治疗效果。结果 两组治疗总有效率无明显差异(P>0.05)；治疗前两组BEHAVE-AD评分无明显差异，治疗后，研究组BEHAVE-AD评分明显低于对照组(P<0.05)，差异具有统计学意义；两组患者在乏力、肝功异常、嗜睡方面无明显差异(P>0.05)，在失眠、激惹、锥体外系反应方面比较差异显著(P<0.05)。结论 采用奥氮平治疗有助于改善老年痴呆精神行为障碍，同时不良反应小，用药安全，可在临床大力推广。
关键词：奥氮平；利培酮；老年痴呆；精神行为障碍；不良反应
中图分类号：R749.1+6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.053
, 百拇医药
文章编号：1006-1959(2018)01-0138-02
The Clinical Efficacy of Olanzapine in the Treatment of Alzheimer's Disease with Mental Behavior Disorder
LU Cong-lin，WANG Xian-dan，YANG Sui-ping，XU Zhi-xiao，MA Neng
(Department of Psychology，Zengdu Hospital，Suizhou 441300，Hubei，China)
Abstract：Objective To observe the improvement of olanzapine and adverse reactions of mental and behavioral disorders in senile dementia effect， to evaluate its clinical efficacy.Methods In our hospital in February 2015～2016 year in October 100 cases of senile dementia patients with mental disorder were as observation objects，grouped according to the order of admission，even as the observation group，single number as the control group，the observation group were treated with olanzapine treatment，the control group were treated with risperidone treatment，compare the efficacy of two groups. Results The total effective rate of two groups had no significant difference(P>0.05)；the two groups before treatment BEHAVE-AD score had no significant difference，after treatment，the study group BEHAVE-AD score was significantly lower than the control group(P<0.05)，with statistically significant differences；There was no significant difference between the two groups in fatigue，abnormal liver function and drowsiness(P>0.05)，but significant differences in insomnia， irritation and extrapyramidal reaction(P<0.05).Conclusion Olanzapine treatment can improve the mental and behavioral disorders of senile dementia，meanwhile，it has the advantages of small adverse reaction and safe medication，which can be popularized clinically.
, 百拇医药
Key words：Olanzapine；Risperidone；Alzheimer's；Mental and behavioral disorders；Adverse reactions
老年癡呆又称为阿尔茨海默症(alzheimer disease，AD)，指起病隐匿的进行性发展的神经系统退行性疾病，患病后，临床症状表现为失语、失认、记忆障碍、视空间技能损害等[1]。老年痴呆不仅有行为紊乱和攻击倾向，还会出现幻觉等精神行为障碍，给患者及家庭带来沉重负担。目前治疗老年痴呆多采用抗精神病药物治疗，传统抗精神病药物会加重患者的意识障碍，还有可能出现严重的锥体外系不良反应，对患者的认知功能造成损害，因此治疗效果并不理想[2]。本研究搜集100例老年痴呆伴精神行为障碍的患者，分别使用奥氮平及利培酮治疗，比较两种药物的疗效与副反应。
1资料与方法
1.1一般资料 将我院2015年2月～2016年10月收治的100例老年痴呆伴精神行为障碍的患者作为观察对象，入组患者符合《中国精神障碍分类与诊断标准第3版(CCMD-3)》及《ICD-10》中关于老年痴呆的诊断标准[3]，所有患者自愿参加本研究。按照入院顺序将患者随机分为两组，各50例。观察组中，男29例，女21例，年龄61～84岁，平均年龄(72.5±3.5)岁，病程2～11 a，平均病程(6.5±0.4)a；对照组中，男26例，女24例，年龄60～81岁，平均年龄(70.5±3.1)岁，病程2～10 a，平均病程(6.0±0.3)a，两组患者在性别、年龄、病程方面比较无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(鲁从林 王先丹 杨遂平 徐志晓 马能)
关键词：奥氮平；利培酮；老年痴呆；精神行为障碍；不良反应
中图分类号：R749.1+6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.01.053
, 百拇医药
文章编号：1006-1959(2018)01-0138-02
The Clinical Efficacy of Olanzapine in the Treatment of Alzheimer's Disease with Mental Behavior Disorder
LU Cong-lin，WANG Xian-dan，YANG Sui-ping，XU Zhi-xiao，MA Neng
(Department of Psychology，Zengdu Hospital，Suizhou 441300，Hubei，China)
Abstract：Objective To observe the improvement of olanzapine and adverse reactions of mental and behavioral disorders in senile dementia effect， to evaluate its clinical efficacy.Methods In our hospital in February 2015～2016 year in October 100 cases of senile dementia patients with mental disorder were as observation objects，grouped according to the order of admission，even as the observation group，single number as the control group，the observation group were treated with olanzapine treatment，the control group were treated with risperidone treatment，compare the efficacy of two groups. Results The total effective rate of two groups had no significant difference(P>0.05)；the two groups before treatment BEHAVE-AD score had no significant difference，after treatment，the study group BEHAVE-AD score was significantly lower than the control group(P<0.05)，with statistically significant differences；There was no significant difference between the two groups in fatigue，abnormal liver function and drowsiness(P>0.05)，but significant differences in insomnia， irritation and extrapyramidal reaction(P<0.05).Conclusion Olanzapine treatment can improve the mental and behavioral disorders of senile dementia，meanwhile，it has the advantages of small adverse reaction and safe medication，which can be popularized clinically.
, 百拇医药
Key words：Olanzapine；Risperidone；Alzheimer's；Mental and behavioral disorders；Adverse reactions
老年癡呆又称为阿尔茨海默症(alzheimer disease，AD)，指起病隐匿的进行性发展的神经系统退行性疾病，患病后，临床症状表现为失语、失认、记忆障碍、视空间技能损害等[1]。老年痴呆不仅有行为紊乱和攻击倾向，还会出现幻觉等精神行为障碍，给患者及家庭带来沉重负担。目前治疗老年痴呆多采用抗精神病药物治疗，传统抗精神病药物会加重患者的意识障碍，还有可能出现严重的锥体外系不良反应，对患者的认知功能造成损害，因此治疗效果并不理想[2]。本研究搜集100例老年痴呆伴精神行为障碍的患者，分别使用奥氮平及利培酮治疗，比较两种药物的疗效与副反应。
1资料与方法
1.1一般资料 将我院2015年2月～2016年10月收治的100例老年痴呆伴精神行为障碍的患者作为观察对象，入组患者符合《中国精神障碍分类与诊断标准第3版(CCMD-3)》及《ICD-10》中关于老年痴呆的诊断标准[3]，所有患者自愿参加本研究。按照入院顺序将患者随机分为两组，各50例。观察组中，男29例，女21例，年龄61～84岁，平均年龄(72.5±3.5)岁，病程2～11 a，平均病程(6.5±0.4)a；对照组中，男26例，女24例，年龄60～81岁，平均年龄(70.5±3.1)岁，病程2～10 a，平均病程(6.0±0.3)a，两组患者在性别、年龄、病程方面比较无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(鲁从林 王先丹 杨遂平 徐志晓 马能)