徐州地区2015～2016年手足口病流行病学特征分析(3)
综上所述，徐州地区HFMD具有明显易感人群及流行季节，可根据此流行病学特征，在疾病流行季节对易感人群进行积极干预，争取早诊断、早治疗，以期获得良好预后。
参考文献：
[1]XU W，LIU CF，YAN L，et al.Distribution of enteroviruses in hospitalized children with hand，foot and mouth disease and relationship between pathogens and nervous system complications[J].Virology journal，2012，9(1)：8.
[2]Teoh HL，Mohammad SS，Britton PN，et al.Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children[J].JAMA neurology，2016，73(3)：300-307.
, 百拇医药
[3]Lee MS，Lin TY，Chiang PS，et al.An investigation of epidemic enterovirus 71 infection in Taiwan，2008：clinical，virologic，and serologic features[J].The Pediatric infectious disease journal，2010，29(11)：1030-1034.
[4]Mirand A，Henquell C，Archimbaud C，et al.Outbreak of hand，foot and mouth disease herpangina associated with coxsackievirus A6 and A10 infections in 2010，France：a large citywide，prospective observational study[J].Clin Microbiol Infect，2012，18(5)：E110-E118.
, 百拇医药
[5]Navarro ME，Almagro LD，Jaldo JR，et al.Outbreak of hand， foot and mouth disease with onychomadesis caused by Coxsackie virus A16 in Granada[J].An Pediatr(Barc)，2015，82(4)：235-241.
[6]Abedi GR，Watson JT，Pgam H，et al.Enterovirus and Human Parechovirus Surveillance-United States，2009-2013[J].Mmwr Morbidity&Mortality Weekly Report，2015，64(34)：940-943.
[7]Miyamoto A，Hirata R，Ishimoto K，et al.An outbreak of hand-foot-and-mouth disease mimicking chicken pox，with a frequent association of onychomadesis in Japan in 2009：a new phenotype caused by coxsackievirus A6[J].Eur J Dermatol，2014，24(1)：103-104.
, 百拇医药
[8]Apalla Z，Sotiriou E，Pikou O，et al.Onychomadesis after hand-foot-and-mouth disease outbreak in northern Greece：case series and brief review of the literature[J].International Journal of Dermatology，2015，54(9)：1039-1044.
[9]Ni H，Yi B，Yin J，et al.Epidemiological and etiological characteristics of hand，foot，and mouth disease in Ningbo，China，2008-2011 [J].J Clin Virol，2012，54(4)：342-348.
[10]De W，Changwen K，Wei L，et al.A large outbreak of hand，foot，and mouth disease caused by EV71 and CAV16 in Guangdong，China，2009[J].Arch Virol，2011，156(6)：945-953.
, 百拇医药
[11]Zhang Y，Tan XJ，Wang HY，et al.An outbreak of hand，foot，and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong，China[J].J Clin Virol，2009，44(4)：262-267.
[12]耿興义，王蔚茹，宁琼，等.2009-2015年济南市手足口病的流行特征分析[J].现代预防医学，2016，43(22)：4044-4050.
[13]樊欢，符院生，单军，等.江苏省3个城市2012-2015年手足口病聚集性与暴发疫情监测分析[J].中华流行病学杂志，2016，37(12)：1608-1614., 百拇医药(李淼 孙浩淼 纵书芳)
参考文献：
[1]XU W，LIU CF，YAN L，et al.Distribution of enteroviruses in hospitalized children with hand，foot and mouth disease and relationship between pathogens and nervous system complications[J].Virology journal，2012，9(1)：8.
[2]Teoh HL，Mohammad SS，Britton PN，et al.Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children[J].JAMA neurology，2016，73(3)：300-307.
, 百拇医药
[3]Lee MS，Lin TY，Chiang PS，et al.An investigation of epidemic enterovirus 71 infection in Taiwan，2008：clinical，virologic，and serologic features[J].The Pediatric infectious disease journal，2010，29(11)：1030-1034.
[4]Mirand A，Henquell C，Archimbaud C，et al.Outbreak of hand，foot and mouth disease herpangina associated with coxsackievirus A6 and A10 infections in 2010，France：a large citywide，prospective observational study[J].Clin Microbiol Infect，2012，18(5)：E110-E118.
, 百拇医药
[5]Navarro ME，Almagro LD，Jaldo JR，et al.Outbreak of hand， foot and mouth disease with onychomadesis caused by Coxsackie virus A16 in Granada[J].An Pediatr(Barc)，2015，82(4)：235-241.
[6]Abedi GR，Watson JT，Pgam H，et al.Enterovirus and Human Parechovirus Surveillance-United States，2009-2013[J].Mmwr Morbidity&Mortality Weekly Report，2015，64(34)：940-943.
[7]Miyamoto A，Hirata R，Ishimoto K，et al.An outbreak of hand-foot-and-mouth disease mimicking chicken pox，with a frequent association of onychomadesis in Japan in 2009：a new phenotype caused by coxsackievirus A6[J].Eur J Dermatol，2014，24(1)：103-104.
, 百拇医药
[8]Apalla Z，Sotiriou E，Pikou O，et al.Onychomadesis after hand-foot-and-mouth disease outbreak in northern Greece：case series and brief review of the literature[J].International Journal of Dermatology，2015，54(9)：1039-1044.
[9]Ni H，Yi B，Yin J，et al.Epidemiological and etiological characteristics of hand，foot，and mouth disease in Ningbo，China，2008-2011 [J].J Clin Virol，2012，54(4)：342-348.
[10]De W，Changwen K，Wei L，et al.A large outbreak of hand，foot，and mouth disease caused by EV71 and CAV16 in Guangdong，China，2009[J].Arch Virol，2011，156(6)：945-953.
, 百拇医药
[11]Zhang Y，Tan XJ，Wang HY，et al.An outbreak of hand，foot，and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong，China[J].J Clin Virol，2009，44(4)：262-267.
[12]耿興义，王蔚茹，宁琼，等.2009-2015年济南市手足口病的流行特征分析[J].现代预防医学，2016，43(22)：4044-4050.
[13]樊欢，符院生，单军，等.江苏省3个城市2012-2015年手足口病聚集性与暴发疫情监测分析[J].中华流行病学杂志，2016，37(12)：1608-1614., 百拇医药(李淼 孙浩淼 纵书芳)