N—末端脑钠肽前体与社区获得性肺炎患者严重程度关系研究(1)
摘 要：目的 探讨血清N-末端脑钠肽前体浓度与社区获得性肺炎的严重程度的关系。方法 对2016年11月～2017年4月于我院呼吸科住院的46例CAP 患者评估临床变量和肺炎严重指数，按照 PSI评分分组，比较各组血清NT-proBNP浓度，评价其与CAP严重程度关系。结果 NT-proBNP与PSI评分、Spearman相关(r=0.654，P<0.05)；NT-proBNP与年龄Spearman相关(r=0.530，P<0.05)；NT-proBNP与呼吸频率Spearman相关(r=0.382，P<0.05)，且各组NT-proBNP浓度随PSI分级升高而升高。NT-proBNP浓度与CAP病情严重程度呈正相关(r=0.654，P<0.05)。结论 NT-proBNP与PSI评分呈显著正相关，其可以作为评估CAP患者病情严重程度的有效指标，但本研究样本量较少，结果可能存在一定的局限性，以及NT-proBNP水平与感染病原体是否相关还需进一步研究。
关键词：社区获得性肺炎；NT-proBNP；PSI评分
, 百拇医药
中图分类号：R563.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.001
文章编号：1006-1959(2018)04-0001-03
Abstract：Objective To investigate the relationship between the concentration of serum N-terminal brain natriuretic peptide(NTP)and the severity of community-acquired pneumonia(CPAP).Methods The clinical variables and the severity index of pneumonia were evaluated in 46 CAP patients hospitalized in respiratory department from November 2016 to April 2017.According to the PSI score，the serum NT-proBNP concentration was compared.Evaluate its relationship with CAP severity.Results NT-proBNP and PSI were correlated with Spearman score (r=0.654，P<0.05)；NT-proBNP was associated with Spearman age(r=0.530，P<0.05).NT-proBNP was correlated with respiratory frequency Spearman(r=0.382，P<0.05)，the concentration of NT-proBNP in each group increased with the increase of PSI grade.The concentration of NT-proBNP was positively correlated with the severity of CAP(r=0.654，P<0.05).Conclusion There is a significant positive correlation between NT-proBNP and PSI score，which can be used as an effective index to evaluate the severity of CAP in patients with CAP.However，the sample size in this study is small，and the results may have some limitations，and whether NT-proBNP levels and pathogen infection related needs further study.
, 百拇医药
Key words：Community-acquired pneumonia；NT-proBNP；PSI score
社區获得性肺炎(community-acquired pneumonia，CAP)是最常见的一种感染性疾病，已经成为全世界范围内较为严重的医疗问题[1]，并且随着年龄增长其发病率及死亡率逐渐升高。N-末端脑钠肽前体(NT-proBNP)由心室肌细胞合成和分泌，其在心力衰竭患者中高表达，是心力衰竭患者的特异性诊断标记物，其水平变化于患者心力衰竭程度及预后有关。近年来国外多项研究显示NT-proBNP水平可作为CAP患者死亡率的独立预测因子[2-4]。本研究通过对46例CAP患者的临床资料进行回顾性分析，探讨NT-proBNP水平与CAP患者病情严重程度的关系。
1 资料与方法
1.1一般资料 选择2016年11月～2017年4月于我院呼吸科住院的CAP患者46例。其中男30例，年龄31～89岁，平均年龄(65.23±14.61)岁，女16例，年龄30～90岁，平均年龄(30.31±17.51)岁。
1.2入排标准 纳入标准：CAP的诊断符合2016年中华医学会呼吸病学分会《中国****获得性肺炎诊断和治疗指南》诊断标准：①社区发病；②肺炎相关临床表现：〇a新近出现的咳嗽、咳痰或原有呼吸道疾病症状加重，伴或不伴脓痰、胸 痛、呼吸困难及咯血；〇b发热；〇c肺实变体征和(或)闻及湿性啰音；〇d外周血白细胞>10×109/L 或<4×109/L，伴或不伴细胞核左移；③胸部影像学检查显示新出现的斑片状浸润影、叶或段实变影、磨玻璃影或间质性改变，伴或不 伴胸腔积液。符合①、③及②中任何一项，并除外肺结核、肺部 肿瘤、非感染性肺间质性疾病、肺水肿、肺不张、肺栓塞、肺嗜酸粒细胞浸润症及肺血管炎等后，可建立临床诊断[5]。排除标准：合并有心力衰竭的患者。, http://www.100md.com(曹立杰 杨林瀛 于国云)
关键词：社区获得性肺炎；NT-proBNP；PSI评分
, 百拇医药
中图分类号：R563.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.001
文章编号：1006-1959(2018)04-0001-03
Abstract：Objective To investigate the relationship between the concentration of serum N-terminal brain natriuretic peptide(NTP)and the severity of community-acquired pneumonia(CPAP).Methods The clinical variables and the severity index of pneumonia were evaluated in 46 CAP patients hospitalized in respiratory department from November 2016 to April 2017.According to the PSI score，the serum NT-proBNP concentration was compared.Evaluate its relationship with CAP severity.Results NT-proBNP and PSI were correlated with Spearman score (r=0.654，P<0.05)；NT-proBNP was associated with Spearman age(r=0.530，P<0.05).NT-proBNP was correlated with respiratory frequency Spearman(r=0.382，P<0.05)，the concentration of NT-proBNP in each group increased with the increase of PSI grade.The concentration of NT-proBNP was positively correlated with the severity of CAP(r=0.654，P<0.05).Conclusion There is a significant positive correlation between NT-proBNP and PSI score，which can be used as an effective index to evaluate the severity of CAP in patients with CAP.However，the sample size in this study is small，and the results may have some limitations，and whether NT-proBNP levels and pathogen infection related needs further study.
, 百拇医药
Key words：Community-acquired pneumonia；NT-proBNP；PSI score
社區获得性肺炎(community-acquired pneumonia，CAP)是最常见的一种感染性疾病，已经成为全世界范围内较为严重的医疗问题[1]，并且随着年龄增长其发病率及死亡率逐渐升高。N-末端脑钠肽前体(NT-proBNP)由心室肌细胞合成和分泌，其在心力衰竭患者中高表达，是心力衰竭患者的特异性诊断标记物，其水平变化于患者心力衰竭程度及预后有关。近年来国外多项研究显示NT-proBNP水平可作为CAP患者死亡率的独立预测因子[2-4]。本研究通过对46例CAP患者的临床资料进行回顾性分析，探讨NT-proBNP水平与CAP患者病情严重程度的关系。
1 资料与方法
1.1一般资料 选择2016年11月～2017年4月于我院呼吸科住院的CAP患者46例。其中男30例，年龄31～89岁，平均年龄(65.23±14.61)岁，女16例，年龄30～90岁，平均年龄(30.31±17.51)岁。
1.2入排标准 纳入标准：CAP的诊断符合2016年中华医学会呼吸病学分会《中国****获得性肺炎诊断和治疗指南》诊断标准：①社区发病；②肺炎相关临床表现：〇a新近出现的咳嗽、咳痰或原有呼吸道疾病症状加重，伴或不伴脓痰、胸 痛、呼吸困难及咯血；〇b发热；〇c肺实变体征和(或)闻及湿性啰音；〇d外周血白细胞>10×109/L 或<4×109/L，伴或不伴细胞核左移；③胸部影像学检查显示新出现的斑片状浸润影、叶或段实变影、磨玻璃影或间质性改变，伴或不 伴胸腔积液。符合①、③及②中任何一项，并除外肺结核、肺部 肿瘤、非感染性肺间质性疾病、肺水肿、肺不张、肺栓塞、肺嗜酸粒细胞浸润症及肺血管炎等后，可建立临床诊断[5]。排除标准：合并有心力衰竭的患者。, http://www.100md.com(曹立杰 杨林瀛 于国云)