整合素α6β1和CD44V4在卵巢上皮癌中表达及相关性分析(1)
摘 要：目的 通过检测上皮癌病理组织及正常卵巢组织中整合素α6β1和CD44V4表达情况，探讨其表达特点与临床病理特征的相关性。方法 收集2015年1月～2016年12月手术切除的20例正常卵巢组织、40例卵巢上皮良性肿瘤及65例卵巢上皮癌组织，利用免疫组织化学法检测整合素α6β1和CD44V4的表达水平，结合病理组织特征进行相关性分析。结果 卵巢上皮癌组织中整合素α6β1和CD44V4的表达水平显著高于正常卵巢及上皮良性肿瘤组织，差异有统计学意义(P<0.05)，且在不同病理分期及分化程度的卵巢上皮癌组织之间的差异有统计学意义(P<0.05)；但在不同组织学分型病理组织中差异无统计学意义(P>0.05)；α6β1和与CD44V4在卵巢上皮癌组织中的表达存在明显正相关(r=0.599，P<0.05)。结论 整合素α6β1和与CD44V4在卵巢上皮癌组织中高表达且有相关性，可作为卵巢上皮癌发展的分子标志物。
关键词：整合素α6β1；CD44V4；卵巢上皮癌
, 百拇医药 中图分类号：R737.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.020
文章编号：1006-1959(2018)04-0062-03
Abstract：Objective To detect the expression of integrin α6β1 and CD44V4 in epithelial carcinoma and normal ovarian tissues，and to explore the correlation between the expression of integrin α6β1 and clinicopathological features.Methods 20 cases of normal ovarian tissue，40 cases of ovarian epithelial benign tumor and 65 cases of epithelial ovarian cancer surgically resected from January 2015 to December 2016 were collected.The expression of integrin α6β1 and CD44V4 were detected by immunohistochemistry.Tissue characteristics for correlation analysis.Results The expression of integrin α6β1 and CD44V4 in ovarian epithelial carcinoma was significantly higher than that in normal ovarian and benign epithelial tumors，the difference was statistically significant(P<0.05)，there was a statistically significant difference in epithelial ovarian cancer between different pathological stages and differentiation degree(P <0.05)，but there was no significant difference in pathological histology among different histological types(P>0.05).There was a significant positive correlation between α6β1 and CD44V4 expression in epithelial ovarian cancer(r=0.599，P<0.05).Conclusion The expression of integrin α6β1 and CD44V4 in epithelial ovarian cancer are highly correlated and may be used as molecular markers for the development of epithelial ovarian cancer.
, 百拇医药
Key words：Integrin α6β1；CD44V4；Epithelial ovarian carcinoma
卵巢肿瘤是发病率仅次于子宫颈癌和子宫体癌的恶性肿瘤，致死率居妇科肿瘤之首，严重威胁女性健康[1]。卵巢恶性肿瘤以上皮癌最常见，明确卵巢上皮癌的发展机制及早期诊断物对该肿瘤的治疗有重要意义[2]。该类肿瘤较强的侵袭及转移能力是临床治疗困难的主要原因，细胞与基质的黏附作用是恶性肿瘤侵袭的重要过程[3]。整合素是主要的细胞黏附分子，整合素α6β1与CD44V4多表达于淋巴细胞和肿瘤细胞表面[4]，可能在卵巢上皮癌的发展中有重要作用。本文通过检测整合素α6β1和CD44V4表达水平，结合临床病理资料进行分析，以探讨整合素α6β1和CD44V4在卵巢上皮癌组织中的表达特点及其相关性。
1资料与方法
1.1一般资料 选取2015年1月～2016年12月萍乡市人民医院妇科行卵巢切除术切除的卵巢上皮癌组织标本65例，卵巢上皮良性肿瘤组织40例，并选取20例正常卵巢组织做对照；所有标本切除前均未接受放化療治疗且经均经病理学专家盲法认定。卵巢上皮癌组织根据临床病例分型分类：根据病理分期(Ⅰ、Ⅱ期13例，Ⅲ、Ⅳ期34例)；组织学分型(子宫内膜样癌13例，粘液性囊腺癌20例，浆液性囊腺癌32例)；病理组织分化程度(低分化34例，中分化19例，高分化12例)。, http://www.100md.com(刘飞 叶帆 杨晓文)
关键词：整合素α6β1；CD44V4；卵巢上皮癌
, 百拇医药 中图分类号：R737.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.020
文章编号：1006-1959(2018)04-0062-03
Abstract：Objective To detect the expression of integrin α6β1 and CD44V4 in epithelial carcinoma and normal ovarian tissues，and to explore the correlation between the expression of integrin α6β1 and clinicopathological features.Methods 20 cases of normal ovarian tissue，40 cases of ovarian epithelial benign tumor and 65 cases of epithelial ovarian cancer surgically resected from January 2015 to December 2016 were collected.The expression of integrin α6β1 and CD44V4 were detected by immunohistochemistry.Tissue characteristics for correlation analysis.Results The expression of integrin α6β1 and CD44V4 in ovarian epithelial carcinoma was significantly higher than that in normal ovarian and benign epithelial tumors，the difference was statistically significant(P<0.05)，there was a statistically significant difference in epithelial ovarian cancer between different pathological stages and differentiation degree(P <0.05)，but there was no significant difference in pathological histology among different histological types(P>0.05).There was a significant positive correlation between α6β1 and CD44V4 expression in epithelial ovarian cancer(r=0.599，P<0.05).Conclusion The expression of integrin α6β1 and CD44V4 in epithelial ovarian cancer are highly correlated and may be used as molecular markers for the development of epithelial ovarian cancer.
, 百拇医药
Key words：Integrin α6β1；CD44V4；Epithelial ovarian carcinoma
卵巢肿瘤是发病率仅次于子宫颈癌和子宫体癌的恶性肿瘤，致死率居妇科肿瘤之首，严重威胁女性健康[1]。卵巢恶性肿瘤以上皮癌最常见，明确卵巢上皮癌的发展机制及早期诊断物对该肿瘤的治疗有重要意义[2]。该类肿瘤较强的侵袭及转移能力是临床治疗困难的主要原因，细胞与基质的黏附作用是恶性肿瘤侵袭的重要过程[3]。整合素是主要的细胞黏附分子，整合素α6β1与CD44V4多表达于淋巴细胞和肿瘤细胞表面[4]，可能在卵巢上皮癌的发展中有重要作用。本文通过检测整合素α6β1和CD44V4表达水平，结合临床病理资料进行分析，以探讨整合素α6β1和CD44V4在卵巢上皮癌组织中的表达特点及其相关性。
1资料与方法
1.1一般资料 选取2015年1月～2016年12月萍乡市人民医院妇科行卵巢切除术切除的卵巢上皮癌组织标本65例，卵巢上皮良性肿瘤组织40例，并选取20例正常卵巢组织做对照；所有标本切除前均未接受放化療治疗且经均经病理学专家盲法认定。卵巢上皮癌组织根据临床病例分型分类：根据病理分期(Ⅰ、Ⅱ期13例，Ⅲ、Ⅳ期34例)；组织学分型(子宫内膜样癌13例，粘液性囊腺癌20例，浆液性囊腺癌32例)；病理组织分化程度(低分化34例，中分化19例，高分化12例)。, http://www.100md.com(刘飞 叶帆 杨晓文)