硝苯地平联合硫酸镁治疗重度妊娠高血压的临床效果分析(1)
摘要：目的 探究硝苯地平联合硫酸镁治疗重度妊娠高血压的临床效果。方法 选取2015年3月～2016年3月在我院接受治疗的50例重度妊娠高血压患者，随机分为观察组和对照组，每组25例。对照组采用硫酸镁治疗，观察组采用硫酸镁联合硝苯地平治疗，对比两组患者的疗效、药物不良反应和胎儿大脑动脉血流动力学指标(PSFV、EDFV、TMFV、PI、RI)变化情况。结果 观察组总有效率为92.00%，高于对照组的64.00%，差异有统计学意义(P<0.05)。观察组药物不良反应发生率为8.00%，低于对照组的36.00%，差异有统计学意义(P<0.05)。观察组胎儿大脑动脉PSFV、EDFV、TMFV、PI、RI的改善情况优于对照组，差异有统计学意义(P<0.05)。结论 硫酸镁联合硝苯地平治疗重度妊娠高血压患者，临床疗效显著，不良反应少，胎儿血流改善情况明显，值得推广。
关键词：重度妊娠高血压；硝苯地平；胎儿血流；硫酸镁
中图分类号：R714.246 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.037
, 百拇医药
文章编号：1006-1959(2018)04-0109-02
Abstract：Objective To explore the clinical effect of nifedipine combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension.Methods 50 patients with severe pregnancy hypertension received treatment in our hospital from March 2015 to March 2016 were randomly divided into observation group and control group with 25 cases in each group.The control group was treated with magnesium sulfate.The observation group was treated with magnesium sulfate combined with nifedipine.The effects of the two groups were compared，the adverse drug reactions and the changes of the fetal cerebral artery hemodynamic indexes (PSFV，EDFV，TMFV，PI，RI)were compared.Results The total effective rate in observation group was 92.00%，which was higher than that in control group 64.00%，the difference was statistically significant(P<0.05).Adverse drug reaction rate in observation group was 8.00%，which was lower than that in control group 36.00%，the difference was statistically significant(P<0.05).The improvement of PSFV，EDFV，TMFV，PI and RI in fetal cerebral artery in observation group was better than that in control group，with significant difference(P<0.05).Conclusion Magnesium sulfate combined with nifedipine in patients with severe pregnancy-induced hypertension has significant clinical efficacy，less adverse reactions，and improved fetal blood flow，which is worthy of promotion.
, 百拇医药
Key words：Severe pregnancy induced hypertension；Nifedipine；Fetal blood flow；Magnesium sulfate
妊娠高血壓综合征(hypertensive disorders in pregnancy)是产科中较常见的临床疾病，是导致孕产妇死亡的重要原因之一，主要临床症状有高血压、蛋白尿和水肿等，严重的产妇会出现不同程度的头痛、眼花、胸闷、抽搐、昏迷和心肾功能衰竭等[1]。硫酸镁是治疗此病的常用药物，但个体间疗效差异较大。本研究采用硝苯地平联合硫酸镁治疗我院25例重度妊娠高血压患者，疗效显著，现报告如下。
1资料与方法
1.1一般资料 选取2015年3月～2016年3月我院重度妊娠高血压患者50例，所有程序通过医院伦理委员会批准。纳入标准：患者均符合妊娠高血压综合症的临床诊断标准；均无其他疾病；均自愿参与此次研究。排除标准：因心、脑、肾疾病引起的高血压患者；具有相关器质性病变的患者。采用随机数字分类法将患者分为观察组和对照组，每组25例。对照组年龄22～48岁，平均年龄(33.62±8.33)岁；观察组年龄26～49岁，平均年龄(37.11±6.40)岁。两组患者一般资料比较，差异无统计学意义(P>0.05)，可对比。, 百拇医药(陈萍 陈磊)
关键词：重度妊娠高血压；硝苯地平；胎儿血流；硫酸镁
中图分类号：R714.246 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.04.037
, 百拇医药
文章编号：1006-1959(2018)04-0109-02
Abstract：Objective To explore the clinical effect of nifedipine combined with magnesium sulfate in the treatment of severe pregnancy induced hypertension.Methods 50 patients with severe pregnancy hypertension received treatment in our hospital from March 2015 to March 2016 were randomly divided into observation group and control group with 25 cases in each group.The control group was treated with magnesium sulfate.The observation group was treated with magnesium sulfate combined with nifedipine.The effects of the two groups were compared，the adverse drug reactions and the changes of the fetal cerebral artery hemodynamic indexes (PSFV，EDFV，TMFV，PI，RI)were compared.Results The total effective rate in observation group was 92.00%，which was higher than that in control group 64.00%，the difference was statistically significant(P<0.05).Adverse drug reaction rate in observation group was 8.00%，which was lower than that in control group 36.00%，the difference was statistically significant(P<0.05).The improvement of PSFV，EDFV，TMFV，PI and RI in fetal cerebral artery in observation group was better than that in control group，with significant difference(P<0.05).Conclusion Magnesium sulfate combined with nifedipine in patients with severe pregnancy-induced hypertension has significant clinical efficacy，less adverse reactions，and improved fetal blood flow，which is worthy of promotion.
, 百拇医药
Key words：Severe pregnancy induced hypertension；Nifedipine；Fetal blood flow；Magnesium sulfate
妊娠高血壓综合征(hypertensive disorders in pregnancy)是产科中较常见的临床疾病，是导致孕产妇死亡的重要原因之一，主要临床症状有高血压、蛋白尿和水肿等，严重的产妇会出现不同程度的头痛、眼花、胸闷、抽搐、昏迷和心肾功能衰竭等[1]。硫酸镁是治疗此病的常用药物，但个体间疗效差异较大。本研究采用硝苯地平联合硫酸镁治疗我院25例重度妊娠高血压患者，疗效显著，现报告如下。
1资料与方法
1.1一般资料 选取2015年3月～2016年3月我院重度妊娠高血压患者50例，所有程序通过医院伦理委员会批准。纳入标准：患者均符合妊娠高血压综合症的临床诊断标准；均无其他疾病；均自愿参与此次研究。排除标准：因心、脑、肾疾病引起的高血压患者；具有相关器质性病变的患者。采用随机数字分类法将患者分为观察组和对照组，每组25例。对照组年龄22～48岁，平均年龄(33.62±8.33)岁；观察组年龄26～49岁，平均年龄(37.11±6.40)岁。两组患者一般资料比较，差异无统计学意义(P>0.05)，可对比。, 百拇医药(陈萍 陈磊)