抗菌肽在炎症治疗方面的进展(3)
[4]Durr UH，Sudheendra US，Ramamoorthy A.LL-37，the only human member of the cathelicidin family of antimicrobial peptides[J].Biochim Biophys Acta，2006，1758(9)：1408-1425.
[5]Yang D，Biragyn A，Hoover DM.Multiple roles of antimicrobial defensins，cathelicidins，and eosinophil-derived neurotoxin in host defense[J].Annu Rev Immunol，2004，22(1)：181-215.
[6]Niyonsaba F，Ogawa H.Protective roles of the skin against infection：Implication of naturally occurring human antimicrobial agents beta-defensins， cathelicidin LL-37 and lysozyme[J].J Dermatol Sci，2005，40(3)：157-168.
, 百拇医药
[7]Braff MH，Bardan A，Nizet V，et al.Cutaneous defense mechanisms by antimicrobial peptides[J].J Invest Dermatol，2005，125(1)：9-13.
[8]Schwab M，Reynders V，Shastri Y，et al.Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells[J].Mol Immunol，2007，44(8)：2107-2114.
[9]Chromek M，Slamová Z，Bergman P，et al.The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection[J].Nat Med，2006，12(6)：636-641.
, 百拇医药
[10]Patel S，Akhtar N.Antimicrobial peptides (AMPs)：The quintessential offense and defense' molecules are more than antimicrobials[J].Biomed Pharmacother，2017，18(95)：1276-1283.
[11]Yeung AT，Gellatly SL，Hancock RE.Multifunctional cationic host defence peptides and their clinical applications[J].Cell Mol Life Sci，2011，68(13)：2161-2176.
[12]Hata TR，Kotol P，Jackson M，et al.Administration of oral vitamin D induces cathelicidin production in atopic individuals[J].J Allergy Clin Immunol，2008，122(4)：829-831.
, http://www.100md.com
[13]Frohm M，Agerberth B，Ahangari G，et al.The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders[J].J Biol Chem，1997，272(24)：15258-15263.
[14]Chamorro CI，Weber G，Gronberg A，et al.The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes[J].J Invest Dermatol，2009，129(4)：937-944.
[15]Vahavihu K，Ala-Houhala M，Peric M，et al.Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis[J].Br J Dermatol，2010，163(2)：321-328.
, 百拇医药
[16]Heilborn JD，Nilsson MF，Kratz G，et al.The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium[J].J Invest Dermatol，2003，120(3)：379-389.
[17]Ramos R，Silva JP，Rodrigues AC，et al.Wound healing activity of the human antimicrobial peptide LL37[J].Peptides，2011，32(7)：1469-1476.
[18]Takahashi T，Gallo RL.The Critical and Multifunctional Roles of Antimicrobial Peptides in Dermatology[J].Dermatol Clin，2017，35(1)：39-50.
, 百拇医药
[19]Zhang Y，Shi W，Tang S.The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis[J].Arthritis Res Ther，2013，15(5)：R161.
[20]姜園园.人类内源性抗菌肽LL-37在慢性阻塞性肺疾病发病机制中作用的研究[D].山东大学，2010.
[21]Phattarataratip E，Olson B，Broffitt B，et al.Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides[J].Mol Oral Microbiol，2011，26(3)：187-199.
收稿日期：2017-10-13；修回日期：2017-10-20
编辑/成森, http://www.100md.com(李谋 杨小琳 赵金礼)
[5]Yang D，Biragyn A，Hoover DM.Multiple roles of antimicrobial defensins，cathelicidins，and eosinophil-derived neurotoxin in host defense[J].Annu Rev Immunol，2004，22(1)：181-215.
[6]Niyonsaba F，Ogawa H.Protective roles of the skin against infection：Implication of naturally occurring human antimicrobial agents beta-defensins， cathelicidin LL-37 and lysozyme[J].J Dermatol Sci，2005，40(3)：157-168.
, 百拇医药
[7]Braff MH，Bardan A，Nizet V，et al.Cutaneous defense mechanisms by antimicrobial peptides[J].J Invest Dermatol，2005，125(1)：9-13.
[8]Schwab M，Reynders V，Shastri Y，et al.Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells[J].Mol Immunol，2007，44(8)：2107-2114.
[9]Chromek M，Slamová Z，Bergman P，et al.The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection[J].Nat Med，2006，12(6)：636-641.
, 百拇医药
[10]Patel S，Akhtar N.Antimicrobial peptides (AMPs)：The quintessential offense and defense' molecules are more than antimicrobials[J].Biomed Pharmacother，2017，18(95)：1276-1283.
[11]Yeung AT，Gellatly SL，Hancock RE.Multifunctional cationic host defence peptides and their clinical applications[J].Cell Mol Life Sci，2011，68(13)：2161-2176.
[12]Hata TR，Kotol P，Jackson M，et al.Administration of oral vitamin D induces cathelicidin production in atopic individuals[J].J Allergy Clin Immunol，2008，122(4)：829-831.
, http://www.100md.com
[13]Frohm M，Agerberth B，Ahangari G，et al.The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders[J].J Biol Chem，1997，272(24)：15258-15263.
[14]Chamorro CI，Weber G，Gronberg A，et al.The human antimicrobial peptide LL-37 suppresses apoptosis in keratinocytes[J].J Invest Dermatol，2009，129(4)：937-944.
[15]Vahavihu K，Ala-Houhala M，Peric M，et al.Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis[J].Br J Dermatol，2010，163(2)：321-328.
, 百拇医药
[16]Heilborn JD，Nilsson MF，Kratz G，et al.The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium[J].J Invest Dermatol，2003，120(3)：379-389.
[17]Ramos R，Silva JP，Rodrigues AC，et al.Wound healing activity of the human antimicrobial peptide LL37[J].Peptides，2011，32(7)：1469-1476.
[18]Takahashi T，Gallo RL.The Critical and Multifunctional Roles of Antimicrobial Peptides in Dermatology[J].Dermatol Clin，2017，35(1)：39-50.
, 百拇医药
[19]Zhang Y，Shi W，Tang S.The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis[J].Arthritis Res Ther，2013，15(5)：R161.
[20]姜園园.人类内源性抗菌肽LL-37在慢性阻塞性肺疾病发病机制中作用的研究[D].山东大学，2010.
[21]Phattarataratip E，Olson B，Broffitt B，et al.Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides[J].Mol Oral Microbiol，2011，26(3)：187-199.
收稿日期：2017-10-13；修回日期：2017-10-20
编辑/成森, http://www.100md.com(李谋 杨小琳 赵金礼)