盐酸米诺环素治疗牙周牙髓综合征的临床效果和安全性分析(1)
摘 要：目的 分析盐酸米诺环素应用于牙周牙髓综合征中疗效和安全性。方法 选取本院2016年8月～2017年8月接收的106例牙周牙髓的綜合征患者，分为研究组和对照组，各53例。对两组皆施予根管治及牙周等基础治疗，对照组在基础治疗上加碘甘油实施治疗，研究组在基础治疗中加盐酸米诺环素进行治疗，对两组疗效加以分析。结果 研究组PD(2.11±0.13)mm，对照组(3.09±0.52)mm，对照组PD更深，差异有统计学意义(P<0.05)；研究组治疗有效率(96.23%)高于对照组(75.47%)，差异有统计学意义(P<0.05)；对照组不良反应率为20.75%，高于研究组的5.66%，差异有统计学意义(P<0.05)。结论 牙周牙髓综合征应用盐酸米诺环素治疗，疗效、安全性皆高。
关键词：牙周牙髓综合征；盐酸米诺环素；安全性
中图分类号：R781 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.042
, 百拇医药
文章编号：1006-1959(2018)06-0126-02
Clinical Efficacy and Safety of Minocycline Hydrochloride in the Treatment of Periodontal Pulp Syndrome
LV Xiao-xia
(Department of Stomatology，People's Hospital of Wufeng County，Wufeng 443400，Hubei，China)
Abstract：Objective To analyze the efficacy and safety of minocycline hydrochloride in periodontal pulp syndrome.Methods 106 patients with periodontal pulp syndrome received in our hospital from August 2016 to August 2017 were divided into study group and control group with 53 cases each.Root canal therapy and periodontal therapy were applied to both groups.The control group was treated with iodine glycerol in the basic treatment.The study group was treated with minocycline hydrochloride in the basic treatment. The efficacy of the two groups was analyzed.Results The research group PD(2.11±0.13)mm，the control group(3.09±0.52)mm，control group PD deeper，the difference was statistically significant(P<0.05)；the study group treatment efficiency(96.23%)was higher than the control group(75.47%)，the difference was statistically significant(P<0.05)；the control group adverse reaction rate of 20.75%，higher than that of group 5.66%，the difference was statistically significant(P<0.05).Conclusion The treatment of periodontitis with minocycline hydrochloride has high efficacy and safety.
, 百拇医药
Key words：Periodontal pulp syndrome；Minocycline hydrochloride；Safety
牙周牙髓综合征(periodontal pulp syndrome)通常是指因患牙的牙周病变发生在较深牙周袋中而引起感染所致，袋中毒素、细菌等可经根尖孔或是副、侧根管进行逆行驶入牙髓中，会在根部引发慢性牙髓炎症[1]。对其通常施以牙周和牙髓的同时治疗，且以局部用药进行辅助治疗[2]。故本院对牙周牙髓综合征施予基础治疗同时加入盐酸米诺环素进行治疗，现报道如下。
1资料与方法
1.1一般资料 选择湖北省宜昌市五峰县人民医院2016年8月～2017年8月接收的106例牙周牙髓的综合征患者，本研究经医院伦理委员会批准。将患者随机分为对照组和研究组，每组53例。对照组中，男性26例，女性27例；年龄27～63岁，平均年龄(41.26±3.57)岁；体质量40～81 kg，平均体质量(54.49±5.51)kg。研究组中，男性25例，女性28例；年龄23～65岁，平均年龄(41.02±3.23)岁；体质量39～83 kg，平均体质量(55.20±5.80)kg。两组一般资料相比，差异无统计学意义(P>0.05)。
1.2方法 对两组皆施予根管治及牙周等基础性治疗，对照组在其基础加碘甘油实施治疗，将碘甘油缓慢注入病患牙周袋的底部，待溢出则止，每周进行1次换药。研究组则在基础治疗中加盐酸米诺环素进行治疗，将盐酸米诺环素逐渐注入牙周袋最底端，给药速度不宜过快，待药物溢出后则停止注射，药物每周实施1次替换；对两组皆治疗4周。, http://www.100md.com(吕晓霞)
关键词：牙周牙髓综合征；盐酸米诺环素；安全性
中图分类号：R781 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.042
, 百拇医药
文章编号：1006-1959(2018)06-0126-02
Clinical Efficacy and Safety of Minocycline Hydrochloride in the Treatment of Periodontal Pulp Syndrome
LV Xiao-xia
(Department of Stomatology，People's Hospital of Wufeng County，Wufeng 443400，Hubei，China)
Abstract：Objective To analyze the efficacy and safety of minocycline hydrochloride in periodontal pulp syndrome.Methods 106 patients with periodontal pulp syndrome received in our hospital from August 2016 to August 2017 were divided into study group and control group with 53 cases each.Root canal therapy and periodontal therapy were applied to both groups.The control group was treated with iodine glycerol in the basic treatment.The study group was treated with minocycline hydrochloride in the basic treatment. The efficacy of the two groups was analyzed.Results The research group PD(2.11±0.13)mm，the control group(3.09±0.52)mm，control group PD deeper，the difference was statistically significant(P<0.05)；the study group treatment efficiency(96.23%)was higher than the control group(75.47%)，the difference was statistically significant(P<0.05)；the control group adverse reaction rate of 20.75%，higher than that of group 5.66%，the difference was statistically significant(P<0.05).Conclusion The treatment of periodontitis with minocycline hydrochloride has high efficacy and safety.
, 百拇医药
Key words：Periodontal pulp syndrome；Minocycline hydrochloride；Safety
牙周牙髓综合征(periodontal pulp syndrome)通常是指因患牙的牙周病变发生在较深牙周袋中而引起感染所致，袋中毒素、细菌等可经根尖孔或是副、侧根管进行逆行驶入牙髓中，会在根部引发慢性牙髓炎症[1]。对其通常施以牙周和牙髓的同时治疗，且以局部用药进行辅助治疗[2]。故本院对牙周牙髓综合征施予基础治疗同时加入盐酸米诺环素进行治疗，现报道如下。
1资料与方法
1.1一般资料 选择湖北省宜昌市五峰县人民医院2016年8月～2017年8月接收的106例牙周牙髓的综合征患者，本研究经医院伦理委员会批准。将患者随机分为对照组和研究组，每组53例。对照组中，男性26例，女性27例；年龄27～63岁，平均年龄(41.26±3.57)岁；体质量40～81 kg，平均体质量(54.49±5.51)kg。研究组中，男性25例，女性28例；年龄23～65岁，平均年龄(41.02±3.23)岁；体质量39～83 kg，平均体质量(55.20±5.80)kg。两组一般资料相比，差异无统计学意义(P>0.05)。
1.2方法 对两组皆施予根管治及牙周等基础性治疗，对照组在其基础加碘甘油实施治疗，将碘甘油缓慢注入病患牙周袋的底部，待溢出则止，每周进行1次换药。研究组则在基础治疗中加盐酸米诺环素进行治疗，将盐酸米诺环素逐渐注入牙周袋最底端，给药速度不宜过快，待药物溢出后则停止注射，药物每周实施1次替换；对两组皆治疗4周。, http://www.100md.com(吕晓霞)