阿司匹林联合硫酸镁治疗妊娠高血压的疗效观察(1)
摘 要：目的 探讨应用阿司匹林联合硫酸镁治疗妊娠高血压的临床疗效。方法 将大连市瓦房店第二医院2015年4月～2017年5月收治的60例妊娠高血压患者，随机分成观察组与对照组，每组30例。对照组单纯使用硫酸镁治疗，观察组在对照组治疗基础上加用阿司匹林，观察两组临床疗效及治疗后患者各项指标情况。结果 观察组治疗总有效率为93.33%，高于对照组73.33%，差异有统计学意义(P<0.05)。观察组患者治疗后血液黏度、尿氮素、尿酸及尿蛋白各项指标水平均低于对照组，差异有统计学意义(P<0.05)。结论 采取阿司匹林联合硫酸镁治疗，可以有效改善妊娠高血压症状。
关键词：阿司匹林；硫酸镁；妊娠高血压
中图分类号：R714.246 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.045
文章编号：1006-1959(2018)06-0133-02
, http://www.100md.com
Clinical Observation of Aspirin Combined with Magnesium Sulfate in the Treatment of Pregnancy-induced Hypertension
YU Ying-jiu1，LIU Jie2
(1.Department of Obstetrics and Gynecology，The Second Wafangdian Hospital，Dalian 116314，Liaoning，China；
2.Wafangdian Maternity and Baby Hospital，Dalian 116300，Liaoning，China)
Abstract：Objective To investigate the clinical efficacy of aspirin combined with magnesium sulfate in the treatment of pregnancy-induced hypertension.Methods 60 patients with pregnancy-induced hypertension treated in Second Wafangdian Hospital of Dalian from April 2015 to May 2017 were randomly divided into two groups： observation group and control group.30 cases in each group. The control group was treated with magnesium sulfate alone，while the observation group was treated with aspirin on the basis of the control group，the clinical efficacy of the two groups and the indexes of the patients after treatment were observed.Results The total effective rate of treatment in the observation group was 93.33%，which was higher than that of the control group 73.33%，and the difference was statistically significant(P<0.05).The blood viscosity，urine nitrogen，uric acid and urine protein in the observation group were lower than those in the control group，and the difference was statistically significant(P<0.05).Conclusion The treatment of aspirin combined with magnesium sulfate can effectively improve the symptoms of pregnancy induced hypertension.
, 百拇医药
Key words：Aspirin；Magnesium sulfate；Pregnancy-induced hypertension
妊娠高血壓(pregnancy-induced hypertension syndrome，PIH)属于临床中常见的危重疾病，患者的临床表现主要为高血压、蛋白尿以及水肿，症状严重的患者还会出现腹部剧烈疼痛、头痛及视力模糊等，这对孕妇的生命健康及生活质量造成巨大影响[1]。现阶段临床中常用硫酸镁治疗妊娠高血压，但是该药物可以有效抑制运动末梢，但是单一使用硫酸镁并不能获得较高临床疗效，且用量如果控制不当容易导致患者出现呼吸抑制，危害母婴安全。近几年临床治疗发现在硫酸镁治疗妊娠高血压过程加用阿司匹林可以进一步改善血流灌注，有效抑制血小板内环氧化酶。本次研究选取大连市瓦房店第二医院2015年4月～2017年5月收治的60例妊娠高血压患者，就探讨阿司匹林与硫酸镁联用治疗妊娠高血压的临床疗效，报道如下。
1 资料与方法
1.1 一般资料 选取大连市瓦房店第二医院2015年4月～2017年5月收治的60例妊娠高血压患者为研究对象，所有患者均符合妊娠期高血压的相关诊断标准，并且排除患有严重心肝肾等器官功能疾病的患者，患者知情并签署同意书。采取随机分组方法将患者分成观察组与对照组，每组30例。观察组年龄22～36岁，平均年龄(27.64±2.75)岁；孕周26～34.2周，平均孕周(31.64±2.62)周。对照组年龄21～35岁，平均年龄(27.14±2.42)岁；孕周25.8～34.1周，平均孕周(31.16±2.32)周。两组患者在年龄、孕周等一般资料对比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(宇英久 刘杰)
关键词：阿司匹林；硫酸镁；妊娠高血压
中图分类号：R714.246 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.06.045
文章编号：1006-1959(2018)06-0133-02
, http://www.100md.com
Clinical Observation of Aspirin Combined with Magnesium Sulfate in the Treatment of Pregnancy-induced Hypertension
YU Ying-jiu1，LIU Jie2
(1.Department of Obstetrics and Gynecology，The Second Wafangdian Hospital，Dalian 116314，Liaoning，China；
2.Wafangdian Maternity and Baby Hospital，Dalian 116300，Liaoning，China)
Abstract：Objective To investigate the clinical efficacy of aspirin combined with magnesium sulfate in the treatment of pregnancy-induced hypertension.Methods 60 patients with pregnancy-induced hypertension treated in Second Wafangdian Hospital of Dalian from April 2015 to May 2017 were randomly divided into two groups： observation group and control group.30 cases in each group. The control group was treated with magnesium sulfate alone，while the observation group was treated with aspirin on the basis of the control group，the clinical efficacy of the two groups and the indexes of the patients after treatment were observed.Results The total effective rate of treatment in the observation group was 93.33%，which was higher than that of the control group 73.33%，and the difference was statistically significant(P<0.05).The blood viscosity，urine nitrogen，uric acid and urine protein in the observation group were lower than those in the control group，and the difference was statistically significant(P<0.05).Conclusion The treatment of aspirin combined with magnesium sulfate can effectively improve the symptoms of pregnancy induced hypertension.
, 百拇医药
Key words：Aspirin；Magnesium sulfate；Pregnancy-induced hypertension
妊娠高血壓(pregnancy-induced hypertension syndrome，PIH)属于临床中常见的危重疾病，患者的临床表现主要为高血压、蛋白尿以及水肿，症状严重的患者还会出现腹部剧烈疼痛、头痛及视力模糊等，这对孕妇的生命健康及生活质量造成巨大影响[1]。现阶段临床中常用硫酸镁治疗妊娠高血压，但是该药物可以有效抑制运动末梢，但是单一使用硫酸镁并不能获得较高临床疗效，且用量如果控制不当容易导致患者出现呼吸抑制，危害母婴安全。近几年临床治疗发现在硫酸镁治疗妊娠高血压过程加用阿司匹林可以进一步改善血流灌注，有效抑制血小板内环氧化酶。本次研究选取大连市瓦房店第二医院2015年4月～2017年5月收治的60例妊娠高血压患者，就探讨阿司匹林与硫酸镁联用治疗妊娠高血压的临床疗效，报道如下。
1 资料与方法
1.1 一般资料 选取大连市瓦房店第二医院2015年4月～2017年5月收治的60例妊娠高血压患者为研究对象，所有患者均符合妊娠期高血压的相关诊断标准，并且排除患有严重心肝肾等器官功能疾病的患者，患者知情并签署同意书。采取随机分组方法将患者分成观察组与对照组，每组30例。观察组年龄22～36岁，平均年龄(27.64±2.75)岁；孕周26～34.2周，平均孕周(31.64±2.62)周。对照组年龄21～35岁，平均年龄(27.14±2.42)岁；孕周25.8～34.1周，平均孕周(31.16±2.32)周。两组患者在年龄、孕周等一般资料对比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(宇英久 刘杰)