非酒精性脂肪性肝病与血尿酸水平测定及其临床意义(1)
摘 要：目的 探討非酒精性脂肪性肝病(NAFLD)与血尿酸水平的关系。方法 选取在我院常规体检的2666例成人，其中经腹部彩超诊断为脂肪肝者为NAFLD组共603例，无脂肪肝者为非NAFLD组共2063例。根据BMI将其分为肥胖组290例及非肥胖组2376例。回顾性分析研究对象的年龄、血压、UA、FBG、TC、TG、LDL、GDL等临床指标。结果 NAFLD组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非NAFLD组，差异具有统计学意义(P<0.05)；而NAFLD组的HDL水平低于非NAFLD组，差异具有统计学意义(P<0.05)。肥胖组的年龄、收缩压、舒张压、UA、FBG、TC、TG、LDL均高于非肥胖组，差异具有统计学意义(P<0.05)；而肥胖组的HDL水平低于非肥胖组，差异具有统计学意义(P<0.05)。在肥胖组中，血尿酸水平与是否发生NAFLD无明显相关关系(r=0.095，P=0.107)，而在非肥胖组中，血尿酸水平与是否发生NAFLD呈正相关关系(r=0.229，P=0.000)。结论 在非肥胖人群中，高尿酸血症可作为NAFLD的独立危险因素，为临床上NAFLD的治疗提供一定的实用价值。
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关键词：非酒精性脂肪性肝病；尿酸；肥胖；代谢综合征
中图分类号：R575.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.029
文章编号：1006-1959(2018)07-0092-03
Determination of Serum Uric Acid Level and its Clinical Significance in Non-alcoholic Fatty Liver Disease
LONG Ying，LI Yun-ze，TANG Zhong-min，CHEN Li-ting
(Department of Digestive Diseases，Liuzhou People's Hospital，Liuzhou 545006，Guangxi，China)
, http://www.100md.com
Abstract：Objective To investigate the relationship between non-alcoholic fatty liver disease(NAFLD)and serum uric acid levels.Methods A total of 2666 adults who received routine physical examination in our hospital were selected.Among them，603 cases were diagnosed as fatty liver by transabdominal color Doppler ultrasound.There were 603 cases in group NAFLD，and 2063 cases without fatty liver in non NAFLD group.According to BMI，it was divided into 290 cases of obesity group and 2376 cases of non obese group. Retrospective analysis of the age，blood pressure，UA，FBG，TC，TG，LDL，GDL and other clinical indicators.Results The age，systolic blood pressure，diastolic blood pressure，UA，FBG，TC，TG，and LDL in the NAFLD group were higher than those in the non-NAFLD group，the difference was statistically significant(P<0.05)，while the HDL levels in the NAFLD group were lower than those in the non-NAFLD group，the difference was statistically significant(P<0.05).The age，systolic blood pressure，diastolic blood pressure，UA，FBG，TC， TG，and LDL in the obese group were higher than those in the non-obese group，the difference was statistically significant(P<0.05)， while the HDL level in the obese group was lower than that in the non-obese group，the difference was statistically significant(P<0.05). In the obese group，there was no significant correlation between serum uric acid level and NAFLD(r=0.095，P=0.107).In non-obese group，serum uric acid level was positively correlated with NAFLD(r=0.229，P=0.000).Conclusion Hyperuricemia can be used as an independent risk factor of NAFLD in non-obese people，which provides a practical value for clinical treatment of NAFLD., http://www.100md.com(龙颖 李运泽 汤中敏 陈丽婷)
, http://www.100md.com
关键词：非酒精性脂肪性肝病；尿酸；肥胖；代谢综合征
中图分类号：R575.5 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.07.029
文章编号：1006-1959(2018)07-0092-03
Determination of Serum Uric Acid Level and its Clinical Significance in Non-alcoholic Fatty Liver Disease
LONG Ying，LI Yun-ze，TANG Zhong-min，CHEN Li-ting
(Department of Digestive Diseases，Liuzhou People's Hospital，Liuzhou 545006，Guangxi，China)
, http://www.100md.com
Abstract：Objective To investigate the relationship between non-alcoholic fatty liver disease(NAFLD)and serum uric acid levels.Methods A total of 2666 adults who received routine physical examination in our hospital were selected.Among them，603 cases were diagnosed as fatty liver by transabdominal color Doppler ultrasound.There were 603 cases in group NAFLD，and 2063 cases without fatty liver in non NAFLD group.According to BMI，it was divided into 290 cases of obesity group and 2376 cases of non obese group. Retrospective analysis of the age，blood pressure，UA，FBG，TC，TG，LDL，GDL and other clinical indicators.Results The age，systolic blood pressure，diastolic blood pressure，UA，FBG，TC，TG，and LDL in the NAFLD group were higher than those in the non-NAFLD group，the difference was statistically significant(P<0.05)，while the HDL levels in the NAFLD group were lower than those in the non-NAFLD group，the difference was statistically significant(P<0.05).The age，systolic blood pressure，diastolic blood pressure，UA，FBG，TC， TG，and LDL in the obese group were higher than those in the non-obese group，the difference was statistically significant(P<0.05)， while the HDL level in the obese group was lower than that in the non-obese group，the difference was statistically significant(P<0.05). In the obese group，there was no significant correlation between serum uric acid level and NAFLD(r=0.095，P=0.107).In non-obese group，serum uric acid level was positively correlated with NAFLD(r=0.229，P=0.000).Conclusion Hyperuricemia can be used as an independent risk factor of NAFLD in non-obese people，which provides a practical value for clinical treatment of NAFLD., http://www.100md.com(龙颖 李运泽 汤中敏 陈丽婷)