胶原蛋白面膜联合口服药物治疗面部激素依赖性皮炎疗效观察(1)
摘 要：目的 观察胶原蛋白面膜在面部激素依赖性皮炎治疗中的有效性。方法 选取2015年5月～2018年1月我院200例面部激素依赖性皮炎患者，采用随机数表法分为治疗组103例和对照组97例。治疗组采用胶原蛋白面膜联合口服复方甘草酸苷胶囊、羟氯喹治疗，对照组单纯口服复方甘草胶囊、羟氯喹治疗，观察两组患者治疗有效率及不良反应情况。结果 治疗组治疗有效率为89.32%，高于对照组的72.16%，组间比较，差异有统计学意义(P<0.01)；治疗后两组患者均未出现明显不良反应，差异无统计学意义(P>0.05)。结论 胶原蛋白面膜联合复方甘草酸苷胶囊、羟氯喹治疗面部激素赖性皮炎疗效确切，可修复皮肤屏障功能，提高治疗效果，不良反应少，值得临床推广。
关键词：胶原蛋白面膜；复方甘草酸苷胶囊；羟氯喹；激素依赖性皮炎
中图分类号：R758.25 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.045
, 百拇医药
文章编号：1006-1959(2018)08-0134-02
Therapeutic Effect of Collagen Facial Mask Combined with Oral Drug in the Treatment of Facial Hormone Dependent Dermatitis
ZHAO Wei-hong
(Baodi Clinical College of Tianjin Medical University，Tianjin 301800，China)
Abstract：Objective To observe the efficacy of collagen mask in the treatment of facial hormone-dependent dermatitis.Methods 200 patients with facial hormone dependent dermatitis from May 2015 to January 2018 were randomly divided into treatment group(n= 103)and control group(n=97).The treatment group was treated with collagen mask combined with oral compound glycyrrhizin capsules and hydroxychloroquine，and the control group was treated with compound glycyrrhiza capsules and hydroxychloroquine，and the efficacy and adverse reactions of the two groups were observed.Results The effective rate of treatment in the treatment group was 89.32%，which was higher than that in the control group 72.16%，the difference between the two groups was statistically significant(P < 0.01)，and there was no significant adverse reaction between the two groups(P>0.05).Conclusion Collagen mask combined with compound glycyrrhizin capsule and hydroxychloroquine are effective in the treatment of facial hormone leisurely dermatitis，which can repair the function of skin barrier and improve the therapeutic effect.
, 百拇医药
Key words：Collagen mask；Compound glycyrrhizin capsule；Hydroxychloroquine；Hormone dependent dermatitis
激素依賴性皮炎(corticosteroid addictive dermatitis)为长期外用糖皮质激素药物而形成的具有明显干燥、瘙痒、灼热等严重自觉症状的慢性皮炎，具有“戒断症状”，多见于中年女性，是一种继发性皮炎。目前对激素依赖性皮炎治疗尚没有统一标准，同时治疗比较棘手，易反复发作，影响患者生活质量。本次研究观察胶原蛋白面膜外用联合口服药物修复皮肤屏障功能的作用，评价其对治疗激素依赖性皮炎的效果，特选取2015年5月～2018年1月我院收治200例激素依赖性皮炎患者，现报告如下。
1资料与方法
1.1一般资料 所有入选患者均为天津市宝坻区人民医院门诊就诊者，符合李吉等[1]提出的面部激素依赖性皮炎的诊断标准，就诊前1个月内未应用过局部和(或)系统药物治疗；无其他皮肤病。入选患者采用随机数字表法分为两组：治疗组103例，其中男32例，女71例，年龄28～52岁，平均年龄(35.80±3.60)岁，病程2个月～2年，平均病程为(0.80±0.40)年，其中玫瑰痤疮样42例，脂溢性皮炎样25例，接触性皮炎样20例，湿疹样16例；对照组97例，其中男41例，女56例，年龄26～51岁，平均年龄(34.30±3.70)岁，病程2个月～2年，平均病程(0.90±0.50)年，其中玫瑰痤疮样45例，脂溢性皮炎样30例，接触性皮炎样10例，湿疹样12例。两组患者性别、年龄、病程等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(赵卫红)
关键词：胶原蛋白面膜；复方甘草酸苷胶囊；羟氯喹；激素依赖性皮炎
中图分类号：R758.25 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.045
, 百拇医药
文章编号：1006-1959(2018)08-0134-02
Therapeutic Effect of Collagen Facial Mask Combined with Oral Drug in the Treatment of Facial Hormone Dependent Dermatitis
ZHAO Wei-hong
(Baodi Clinical College of Tianjin Medical University，Tianjin 301800，China)
Abstract：Objective To observe the efficacy of collagen mask in the treatment of facial hormone-dependent dermatitis.Methods 200 patients with facial hormone dependent dermatitis from May 2015 to January 2018 were randomly divided into treatment group(n= 103)and control group(n=97).The treatment group was treated with collagen mask combined with oral compound glycyrrhizin capsules and hydroxychloroquine，and the control group was treated with compound glycyrrhiza capsules and hydroxychloroquine，and the efficacy and adverse reactions of the two groups were observed.Results The effective rate of treatment in the treatment group was 89.32%，which was higher than that in the control group 72.16%，the difference between the two groups was statistically significant(P < 0.01)，and there was no significant adverse reaction between the two groups(P>0.05).Conclusion Collagen mask combined with compound glycyrrhizin capsule and hydroxychloroquine are effective in the treatment of facial hormone leisurely dermatitis，which can repair the function of skin barrier and improve the therapeutic effect.
, 百拇医药
Key words：Collagen mask；Compound glycyrrhizin capsule；Hydroxychloroquine；Hormone dependent dermatitis
激素依賴性皮炎(corticosteroid addictive dermatitis)为长期外用糖皮质激素药物而形成的具有明显干燥、瘙痒、灼热等严重自觉症状的慢性皮炎，具有“戒断症状”，多见于中年女性，是一种继发性皮炎。目前对激素依赖性皮炎治疗尚没有统一标准，同时治疗比较棘手，易反复发作，影响患者生活质量。本次研究观察胶原蛋白面膜外用联合口服药物修复皮肤屏障功能的作用，评价其对治疗激素依赖性皮炎的效果，特选取2015年5月～2018年1月我院收治200例激素依赖性皮炎患者，现报告如下。
1资料与方法
1.1一般资料 所有入选患者均为天津市宝坻区人民医院门诊就诊者，符合李吉等[1]提出的面部激素依赖性皮炎的诊断标准，就诊前1个月内未应用过局部和(或)系统药物治疗；无其他皮肤病。入选患者采用随机数字表法分为两组：治疗组103例，其中男32例，女71例，年龄28～52岁，平均年龄(35.80±3.60)岁，病程2个月～2年，平均病程为(0.80±0.40)年，其中玫瑰痤疮样42例，脂溢性皮炎样25例，接触性皮炎样20例，湿疹样16例；对照组97例，其中男41例，女56例，年龄26～51岁，平均年龄(34.30±3.70)岁，病程2个月～2年，平均病程(0.90±0.50)年，其中玫瑰痤疮样45例，脂溢性皮炎样30例，接触性皮炎样10例，湿疹样12例。两组患者性别、年龄、病程等一般资料比较，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(赵卫红)