糖化血红蛋白测定在糖尿病诊断中的应用价值分析(1)
摘 要：目的 研究糖化血红蛋白(HbAlc)测定在糖尿病诊断中的应用。方法 选择我院2015年11月～2016年9月收治的2型糖尿病患者60例为研究组，再选择同期健康体检者60例对照组。两组入选者均于清晨抽取2 ml空腹静脉血，采用常规微粒色谱法进行测量两组入选者的HbAlc，同时对空腹血糖(FPG)与餐后2 h血糖(2hPG)进行测量。对比两组入选者的HbAlc、FPG、2hPG以及HbAlc达标率。结果 研究组HbAlc、FPG、2hPG分别为(8.89±0.67)%、(7.58±0.98)mmol/L、(12.26±2.23)mmol/L，均优于对照组的(3.56±1.21)%、(3.85±1.41)mmol/L、(7.23±2.04)mmol/L，差异有统计学意义(P<0.05)。研究组HbAlc达标率为8.33%，低于对照组的91.67%，差异有统计学意义(P<0.05)。结论 对2型糖尿病患者实施糖化血红蛋白检测，临床诊断较为可靠，诊断准确率较高，对糖尿病患者尽早治疗起到关键作用，值得临床进一步研究。
关键词：糖尿病；诊断；糖化血红蛋白；血糖
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中图分类号：R587.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.057
文章编号：1006-1959(2018)08-0161-02
Analysis of the Value of Determination of Glycosylated Hemoglobin in the Diagnosis of Diabetes Mellitus
LIU Ai-jun
(Department of Laboratory，Binhai Hospital，Tianjin Medical University General Hospital，Tianjin 300480，China)
Abstract：Objective To study the application of glycosylated hemoglobin (HbAlc) in the diagnosis of diabetes.Methods 60 patients with type 2 diabetes admitted to our hospital from November 2015 to September 2016 were selected as the study group，and 60 healthy controls were selected as the control group.The two groups selected 2 ml of fasting venous blood in the early morning and measured the HbAlc in the two groups by conventional microparticle chromatography，and measured fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2hPG).The HbAlc，FPG，2hPG，and HbAlc compliance rates were compared between the two groups. Results The HbAlc，FPG，and 2hPG in the study group were(8.89±0.67)%，(7.58±0.98)mmol/L，and(12.26±2.23)mmol/L，all of them were superior to the control group(3.56±1.21)%，(3.85±1.41)mmol/L，(7.23±2.04)mmol/L，and the difference was statistically significant(P<0.05).The HbAlc compliance rate of the study group was 8.33%，which was lower than that of the control group 91.67%，the difference was statistically significant(P<0.05).Conclusion The glycosylated hemoglobin test in patients with type 2 diabetes is more reliable in clinical diagnosis and higher in diagnostic accuracy.It plays a key role in the early treatment of diabetic patients and deserves further clinical investigation.
Key words：Diabetes；Diagnosis；Glycated hemoglobin；Blood glucose
糖尿病(diabetes mellitus，DM)是是一組以高血糖为特征的代谢性疾病，分为1型和2型。2型糖尿病多因患者肥胖、遗传、环境等诸多原因导致，患者大多数在35～40岁以后发病，其临床表现为肥胖，导致胰岛素敏感性降低，且体内胰岛素基本完全丧失[1]。而持续的高血糖会导致患者其他器官，甚至肾、心血管衰竭，因此糖尿病需要尽早预防与治疗。而临床常规检查时，需要患者选择空腹或者早晨进行测量，时间上有一定的限制，对疾病的准确诊断造成一定影响。本文研究HbAlc测定在糖尿病诊断中的应用，旨在提高检查的准确率，现报道如下。, 百拇医药(刘爱君)
关键词：糖尿病；诊断；糖化血红蛋白；血糖
, http://www.100md.com
中图分类号：R587.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.08.057
文章编号：1006-1959(2018)08-0161-02
Analysis of the Value of Determination of Glycosylated Hemoglobin in the Diagnosis of Diabetes Mellitus
LIU Ai-jun
(Department of Laboratory，Binhai Hospital，Tianjin Medical University General Hospital，Tianjin 300480，China)
Abstract：Objective To study the application of glycosylated hemoglobin (HbAlc) in the diagnosis of diabetes.Methods 60 patients with type 2 diabetes admitted to our hospital from November 2015 to September 2016 were selected as the study group，and 60 healthy controls were selected as the control group.The two groups selected 2 ml of fasting venous blood in the early morning and measured the HbAlc in the two groups by conventional microparticle chromatography，and measured fasting plasma glucose(FPG)and 2 h postprandial blood glucose(2hPG).The HbAlc，FPG，2hPG，and HbAlc compliance rates were compared between the two groups. Results The HbAlc，FPG，and 2hPG in the study group were(8.89±0.67)%，(7.58±0.98)mmol/L，and(12.26±2.23)mmol/L，all of them were superior to the control group(3.56±1.21)%，(3.85±1.41)mmol/L，(7.23±2.04)mmol/L，and the difference was statistically significant(P<0.05).The HbAlc compliance rate of the study group was 8.33%，which was lower than that of the control group 91.67%，the difference was statistically significant(P<0.05).Conclusion The glycosylated hemoglobin test in patients with type 2 diabetes is more reliable in clinical diagnosis and higher in diagnostic accuracy.It plays a key role in the early treatment of diabetic patients and deserves further clinical investigation.
Key words：Diabetes；Diagnosis；Glycated hemoglobin；Blood glucose
糖尿病(diabetes mellitus，DM)是是一組以高血糖为特征的代谢性疾病，分为1型和2型。2型糖尿病多因患者肥胖、遗传、环境等诸多原因导致，患者大多数在35～40岁以后发病，其临床表现为肥胖，导致胰岛素敏感性降低，且体内胰岛素基本完全丧失[1]。而持续的高血糖会导致患者其他器官，甚至肾、心血管衰竭，因此糖尿病需要尽早预防与治疗。而临床常规检查时，需要患者选择空腹或者早晨进行测量，时间上有一定的限制，对疾病的准确诊断造成一定影响。本文研究HbAlc测定在糖尿病诊断中的应用，旨在提高检查的准确率，现报道如下。, 百拇医药(刘爱君)