机体外伤应激状态时血常规的变化情况观察(1)
摘 要：目的 探究机体外伤应激状态时血常规的变化，以期为应激性病理变化的治疗和预防提供有效依据。方法 选取瓦房店第二医院2015年6月～2017年6月收治的复合骨折外伤患者80例作为观察组，并选择同期在我院进行健康体检者80例作为对照组，检测并对比两组患者血液应激标志物及血常规差异。结果 观察组患者空腹血糖和超敏C反应蛋白水平，高于对照组，差异有统计学意义(P<0.05)。观察组红细胞数、淋巴细胞数、血小板数，低于对照组；白细胞数、中性粒细胞绝对值、单核细胞数，高于对照组，差异均有统计学意义(P<0.05)。结论 机体外伤应激状态患者血常规指标会出现明显改变，因此可以通过血常规变化为应激性疾病的预防和治疗提供参考指标。
关键词：机体外伤；应激反应；血常规
中图分类号：R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.09.053
文章编号：1006-1959(2018)09-0161-02
, 百拇医药
Abstract：Objective To investigate the changes of blood routine during traumatic stress，and to provide effective basis for the treatment and prevention of stress pathological changes.Methods From June 2015 to June 2017，80 patients with multiple fracture injuries were selected as observation group，and 80 patients who underwent physical examination in our hospital were selected as control group.Blood stress markers and blood routine were detected and compared between the two groups.Results The levels of fasting blood glucose and hypersensitive C-reactive protein in the observation group were higher than those in the control group，the difference was statistically significant(P<0.05).The number of erythrocytes，lymphocytes and platelets in the observation group was lower than that in the control group，while the number of white blood cells，the absolute value of neutrophils and the number of monocytes in the observation group were higher than those in the control group，the difference was statistically significant(P<0.05). Conclusion The blood routine index of the patients with stress in the body can be changed obviously，so it can be used as a reference index for the prevention and treatment of stress disease through the change of blood routine.
, http://www.100md.com
Key words：Body trauma；Stress response；Blood routine
應激反应(stress response)是机体在遭受创伤、手术、炎症、烧伤等刺激时会出现全身性的非特异性适应反应，导致机体免疫系统、神经系统和内分泌系统等协调稳定性造成影响[1，2]。这种应激性非特异适应反应会导致机体合成代谢减少，分解代谢增加，炎症介质增加，长期下去会引起机体组织损伤和功能紊乱，诱发各类并发性应激疾病(stress disease)[3]。血常规指标一直是临床上判断患者生理状况和疾病状况的重要依据，血常规检查主要是对血液中细胞成分的质量和数量变化进行判断，机体外伤患者应激状态下会导致交感-肾上腺髓系统兴奋促进细胞因子、儿茶酚胺、糖皮质激素等的释放促使血液发生变化[4]。本研究对复合骨折外伤患者和正常体检者的血常规指标进行了检测和比较，以期为机体应急程度及相关应激性疾病的诊断和治疗提供依据，现分析如下。
1资料与方法
, http://www.100md.com
1.1一般资料 选取瓦房店第二医院2015年6月～2017年6月收治的复合骨折外伤患者80例作为观察组，纳入标准：①所有患者经X线等影像学检查确诊；②均对本研究知情且能配合完成此次研究；③无血液系统疾病。排除标准：①肝肾等重要器官严重病变；②妊娠及哺乳期妇女；③细菌感染及慢性病患者；④其他应激源因素干扰。观察组男性48例，女性32例，年龄18～48岁，平均年龄(35.41±2.93)岁，另选取同期来我院健康体检的80例正常人群作为对照组，男性45例，女性35例，年龄20～48岁，平均年龄(36.62±3.30)岁。两组一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
1.2.1检查方法 观察组患者在入院后第2天清晨空腹抽取5 ml静脉血，加入EDTA-K2抗凝，离心弃去上清，-80℃冰箱中保存待测。对照组体检人员于清晨空腹状态下同样抽取5 ml静脉血，其余方法相同。, 百拇医药(卢秀军)
关键词：机体外伤；应激反应；血常规
中图分类号：R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.09.053
文章编号：1006-1959(2018)09-0161-02
, 百拇医药
Abstract：Objective To investigate the changes of blood routine during traumatic stress，and to provide effective basis for the treatment and prevention of stress pathological changes.Methods From June 2015 to June 2017，80 patients with multiple fracture injuries were selected as observation group，and 80 patients who underwent physical examination in our hospital were selected as control group.Blood stress markers and blood routine were detected and compared between the two groups.Results The levels of fasting blood glucose and hypersensitive C-reactive protein in the observation group were higher than those in the control group，the difference was statistically significant(P<0.05).The number of erythrocytes，lymphocytes and platelets in the observation group was lower than that in the control group，while the number of white blood cells，the absolute value of neutrophils and the number of monocytes in the observation group were higher than those in the control group，the difference was statistically significant(P<0.05). Conclusion The blood routine index of the patients with stress in the body can be changed obviously，so it can be used as a reference index for the prevention and treatment of stress disease through the change of blood routine.
, http://www.100md.com
Key words：Body trauma；Stress response；Blood routine
應激反应(stress response)是机体在遭受创伤、手术、炎症、烧伤等刺激时会出现全身性的非特异性适应反应，导致机体免疫系统、神经系统和内分泌系统等协调稳定性造成影响[1，2]。这种应激性非特异适应反应会导致机体合成代谢减少，分解代谢增加，炎症介质增加，长期下去会引起机体组织损伤和功能紊乱，诱发各类并发性应激疾病(stress disease)[3]。血常规指标一直是临床上判断患者生理状况和疾病状况的重要依据，血常规检查主要是对血液中细胞成分的质量和数量变化进行判断，机体外伤患者应激状态下会导致交感-肾上腺髓系统兴奋促进细胞因子、儿茶酚胺、糖皮质激素等的释放促使血液发生变化[4]。本研究对复合骨折外伤患者和正常体检者的血常规指标进行了检测和比较，以期为机体应急程度及相关应激性疾病的诊断和治疗提供依据，现分析如下。
1资料与方法
, http://www.100md.com
1.1一般资料 选取瓦房店第二医院2015年6月～2017年6月收治的复合骨折外伤患者80例作为观察组，纳入标准：①所有患者经X线等影像学检查确诊；②均对本研究知情且能配合完成此次研究；③无血液系统疾病。排除标准：①肝肾等重要器官严重病变；②妊娠及哺乳期妇女；③细菌感染及慢性病患者；④其他应激源因素干扰。观察组男性48例，女性32例，年龄18～48岁，平均年龄(35.41±2.93)岁，另选取同期来我院健康体检的80例正常人群作为对照组，男性45例，女性35例，年龄20～48岁，平均年龄(36.62±3.30)岁。两组一般资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
1.2.1检查方法 观察组患者在入院后第2天清晨空腹抽取5 ml静脉血，加入EDTA-K2抗凝，离心弃去上清，-80℃冰箱中保存待测。对照组体检人员于清晨空腹状态下同样抽取5 ml静脉血，其余方法相同。, 百拇医药(卢秀军)