血清脂联素水平与轻度认知功能障碍的相关性研究(1)
摘 要：目的 探讨血清脂联素水平与轻度认知功能障碍的相关性及其临床意义。方法 选取2015年7月～2017年7月在我院神经内科干部病区收治的轻度认知功能障碍患者45例作为病例组，体检中心随机选取年龄相匹配的45例健康体检者作为对照组，对患者血清脂联素水平进行检测，分析其与轻度认知功能障碍的相关性；并将可能影响认知功能的危险因数如血清脂联素水平、超敏C反应蛋白、年龄、吸烟史、糖尿病、高血压、血脂等引入非条件Logistic回归分析，判断血清脂联素是否为轻度认知功能障碍的危险因素。结果 轻度认知功能障碍患者血清脂联素水平，低于健康对照组，差异有统计学意义(P<0.01)。经Logistic回归分析显示：血清脂联素水平与轻度认知功能障碍呈负相关(r=-0.612，P<0.05)，低血清脂联素水平是轻度认知功能障碍的危险因素；此外超敏C反应蛋白升高是轻度认知功能障碍的危险因素。结论 MCI患者的血清脂联素水平显著减低，hsCRP水平升高，APN和hsCRP升高可能是輕度认知功能障碍的危险因素。
关键词：脂联素；轻度认知功能障碍；痴呆
, 百拇医药
中图分类号：R446.1；R749.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.003
文章编号：1006-1959(2018)10-0007-04
Correlation between Serum Adiponectin Level and Mild Cognitive Impairment
LIU Bo，LUO Wen-jing，ZHANG Yi，WEI Chun-ying，YANG Peng，TAO Ran，LIU Jun，HAN Min
(Department of Neurology，Cadre's Sick Area，Guangxi Zhuang Autonomous Region People's Hospital，Nanning 530021，Guangxi，China)
, 百拇医药
Abstract：Objective To investigate the correlation between serum adiponectin level and mild cognitive impairment and its clinical significance.Methods We selected 45 patients with mild cognitive impairment from July 2015 to July 2017 in our department of neurology as the case group.The physical examination center randomly selected age-matched 45 healthy checkers as the control group.The serum adiponectin level of the patient was examined to analyze its correlation with mild cognitive impairment；and the risk factors that may affect cognitive function such as serum adiponectin level，high-sensitivity C-reactive protein，age，smoking history， diabetes，hypertension，and blood lipids were introduced into non-conditional Logistic regression analysis to determine whether serum adiponectin is a risk factor for mild cognitive impairment.Results The serum adiponectin level in patients with mild cognitive impairment was lower than that in healthy controls，the difference was statistically significant(P<0.01).Logistic regression analysis showed that there was a negative correlation between serum adiponectin level and mild cognitive impairmen(r=-0.612，P<0.05)，low serum adiponectin level is a risk factor for mild cognitive impairment，and high sensitivity C-reactive protein is a risk factor for mild cognitive impairment.Conclusion Serum adiponectin levels in patients with MCI are significantly reduced，hsCRP levels are elevated， and elevated APN and hsCRP levels may be a risk factor for mild cognitive impairment.
, 百拇医药
Key words：Adiponectin；Mild cognitive impairment；Dementia
轻度认知功能障碍(mild cognitive impairment， MCI)是指患者有记忆或认知损害，但日常生活能力未受明显影响，介于正常老化与早期老年性痴呆之间的一种过渡阶段，部分轻度认知功能障碍患者会发展为痴呆[1]。现已被公认为是“痴呆的前期状态”，也是进行药物干预治疗的最佳阶段。因此，早期发现MCI患者，查找可靠的生物学预测指标，对于早期干预MCI和延迟或阻止痴呆的发生或发展具有重要意义。但MCI的发病机制极为复杂，与多种因素相关。现在这方面的研究已经扩展到MCI相关危险因素，如糖代谢、脂代谢、炎症及高血压等。近年来，有学者在对糖脂代谢异常与认知功能障碍关系的研究中发现脂联素代谢异常是一个重要的因素，并推测脂联素可能是认知功能障碍的保护因子[2]。目前血清脂联素(APN)与MCI之间的关系仍存在争议，且国内关于脂联素水平与轻度认知功能障碍的相关性研究仍较少，结果尚不确切。因此，本研究旨在通过探讨血清APN水平与MCI的相关性，为预防和干预MCI的发生发展提供新的思路，对MCI患者的诊治具有重要的理论和临床意义。, 百拇医药(刘波 罗文静 张翼)
关键词：脂联素；轻度认知功能障碍；痴呆
, 百拇医药
中图分类号：R446.1；R749.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.003
文章编号：1006-1959(2018)10-0007-04
Correlation between Serum Adiponectin Level and Mild Cognitive Impairment
LIU Bo，LUO Wen-jing，ZHANG Yi，WEI Chun-ying，YANG Peng，TAO Ran，LIU Jun，HAN Min
(Department of Neurology，Cadre's Sick Area，Guangxi Zhuang Autonomous Region People's Hospital，Nanning 530021，Guangxi，China)
, 百拇医药
Abstract：Objective To investigate the correlation between serum adiponectin level and mild cognitive impairment and its clinical significance.Methods We selected 45 patients with mild cognitive impairment from July 2015 to July 2017 in our department of neurology as the case group.The physical examination center randomly selected age-matched 45 healthy checkers as the control group.The serum adiponectin level of the patient was examined to analyze its correlation with mild cognitive impairment；and the risk factors that may affect cognitive function such as serum adiponectin level，high-sensitivity C-reactive protein，age，smoking history， diabetes，hypertension，and blood lipids were introduced into non-conditional Logistic regression analysis to determine whether serum adiponectin is a risk factor for mild cognitive impairment.Results The serum adiponectin level in patients with mild cognitive impairment was lower than that in healthy controls，the difference was statistically significant(P<0.01).Logistic regression analysis showed that there was a negative correlation between serum adiponectin level and mild cognitive impairmen(r=-0.612，P<0.05)，low serum adiponectin level is a risk factor for mild cognitive impairment，and high sensitivity C-reactive protein is a risk factor for mild cognitive impairment.Conclusion Serum adiponectin levels in patients with MCI are significantly reduced，hsCRP levels are elevated， and elevated APN and hsCRP levels may be a risk factor for mild cognitive impairment.
, 百拇医药
Key words：Adiponectin；Mild cognitive impairment；Dementia
轻度认知功能障碍(mild cognitive impairment， MCI)是指患者有记忆或认知损害，但日常生活能力未受明显影响，介于正常老化与早期老年性痴呆之间的一种过渡阶段，部分轻度认知功能障碍患者会发展为痴呆[1]。现已被公认为是“痴呆的前期状态”，也是进行药物干预治疗的最佳阶段。因此，早期发现MCI患者，查找可靠的生物学预测指标，对于早期干预MCI和延迟或阻止痴呆的发生或发展具有重要意义。但MCI的发病机制极为复杂，与多种因素相关。现在这方面的研究已经扩展到MCI相关危险因素，如糖代谢、脂代谢、炎症及高血压等。近年来，有学者在对糖脂代谢异常与认知功能障碍关系的研究中发现脂联素代谢异常是一个重要的因素，并推测脂联素可能是认知功能障碍的保护因子[2]。目前血清脂联素(APN)与MCI之间的关系仍存在争议，且国内关于脂联素水平与轻度认知功能障碍的相关性研究仍较少，结果尚不确切。因此，本研究旨在通过探讨血清APN水平与MCI的相关性，为预防和干预MCI的发生发展提供新的思路，对MCI患者的诊治具有重要的理论和临床意义。, 百拇医药(刘波 罗文静 张翼)