冠状动脉介入治疗冠心病的疗效及对患者血清炎症因子的影响(1)
摘 要：目的 探讨冠状动脉介入治疗冠心病(CHD)的疗效及对患者血清炎症因子的影响。方法 收集我院自2015年10月～2017年11月收治的CHD患者120例作为观察对象，按治疗方式的不同分为实验组与对照组，每组60例。对照组给予常规药物对症治疗，实验组则给予经皮冠状动脉介入(PCI)治疗，对比两组治疗效果以及治疗前后IL-6、CRP、TNF-α等血清炎症因子变化情况。结果 实验组治疗总有效率为93.33%，高于对照组的78.33%，差异有统计学意义(P<0.05)。治疗前，两组患者血清炎症因子IL-6、CRP、TNF-α水平比较，差异无统计学意义(P>0.05)。治疗后7 d，实验组IL-6为(12.14±3.57)pg/L、CRP为(5.40±2.41)mg/L、TNF-α为(9.61±3.12)ng/ml，均分别低于对照组的(14.02±3.64)pg/L、(8.26±2.58)mg/L、(12.28±3.56)ng/ml，差异有统计学意义(P<0.05)。结论 冠状动脉介入治疗CHD疗效显著，可有效下调患者血清炎症因子水平，促进康复，具有较高的推广价值。
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关键词：PCI；冠心病；炎症因子
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.023
文章编号：1006-1959(2018)10-0077-03
Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors
MAO Hong-yan
(Department of Cardiology，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China)
, 百拇医药
Abstract：Objective To investigate the effect of coronary intervention on coronary heart disease(CHD)and its effect on serum inflammatory factors.Methods A total of 120 patients with CHD admitted to our hospital from October 2015 to November 2017 were collected for observation.According to different treatment methods，the patients were divided into experimental group and control group， with 60 patients in each group.The control group was given symptomatic treatment with conventional drugs.The experimental group was treated with percutaneous coronary intervention(PCI).The effect of treatment and the change of serum inflammatory factors such as IL-6，CRP and TNF-α before and after treatment were compared.Results The total effective rate of the treatment group was 93.33%， which was higher than that of the control group 78.33%，the difference was statistically significant(P<0.05).Before treatment，the levels of serum inflammatory cytokines IL-6，CRP，and TNF-α in the two groups were not statistically different(P>0.05).7 d after treatment， IL-6 in the experimental group was(12.14±3.57)pg/L，CRP was(5.40±2.41)mg/L，and TNF-α was(9.61±3.12)ng/ml，both were significantly lower than the control group(14.02±3.64)pg/L，(8.26±2.58)mg/L，(12.28±3.56)ng/ml，and the difference was statistically significant(P<0.05).Conclusion Coronary interventional therapy for CHD is effective and can effectively reduce the serum inflammatory factor levels and promote rehabilitation.It has a higher value for promotion.
, http://www.100md.com
Key words：PCI；Coronary heart disease；Inflammatory factors
冠心病(coronary heart disease，CHD)是現阶段临床上最常见的一种可严重危害人类健康的心血管内科疾病，具有病情危重、致残率及致死率高等特点。相关研究显示[1]，CHD的病理学特征除了与胆固醇聚集、细胞增殖以及血管壁损伤有关之外，其还表现为一种慢性炎症过程，是血管对损伤的一种反应，换言之，炎症参与了不稳定斑块的发生、演变以及破裂过程。传统的药物保守治疗虽然能够在一定程度上改善患者的预后，但治疗过程中存在较多并发症，因而难以继续推广[2]。目前经皮冠状动脉介入(percutaneous coronary intervention，PCI)的发展为治疗CHD带来了新的突破，但就PCI对CHD患者炎症因子的影响的研究鲜少报道。为此，我院进一步探讨了PCI治疗CHD的疗效及对患者血清炎症因子的影响，现将结果报道如下。, 百拇医药(毛红岩)
, http://www.100md.com
关键词：PCI；冠心病；炎症因子
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.023
文章编号：1006-1959(2018)10-0077-03
Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors
MAO Hong-yan
(Department of Cardiology，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China)
, 百拇医药
Abstract：Objective To investigate the effect of coronary intervention on coronary heart disease(CHD)and its effect on serum inflammatory factors.Methods A total of 120 patients with CHD admitted to our hospital from October 2015 to November 2017 were collected for observation.According to different treatment methods，the patients were divided into experimental group and control group， with 60 patients in each group.The control group was given symptomatic treatment with conventional drugs.The experimental group was treated with percutaneous coronary intervention(PCI).The effect of treatment and the change of serum inflammatory factors such as IL-6，CRP and TNF-α before and after treatment were compared.Results The total effective rate of the treatment group was 93.33%， which was higher than that of the control group 78.33%，the difference was statistically significant(P<0.05).Before treatment，the levels of serum inflammatory cytokines IL-6，CRP，and TNF-α in the two groups were not statistically different(P>0.05).7 d after treatment， IL-6 in the experimental group was(12.14±3.57)pg/L，CRP was(5.40±2.41)mg/L，and TNF-α was(9.61±3.12)ng/ml，both were significantly lower than the control group(14.02±3.64)pg/L，(8.26±2.58)mg/L，(12.28±3.56)ng/ml，and the difference was statistically significant(P<0.05).Conclusion Coronary interventional therapy for CHD is effective and can effectively reduce the serum inflammatory factor levels and promote rehabilitation.It has a higher value for promotion.
, http://www.100md.com
Key words：PCI；Coronary heart disease；Inflammatory factors
冠心病(coronary heart disease，CHD)是現阶段临床上最常见的一种可严重危害人类健康的心血管内科疾病，具有病情危重、致残率及致死率高等特点。相关研究显示[1]，CHD的病理学特征除了与胆固醇聚集、细胞增殖以及血管壁损伤有关之外，其还表现为一种慢性炎症过程，是血管对损伤的一种反应，换言之，炎症参与了不稳定斑块的发生、演变以及破裂过程。传统的药物保守治疗虽然能够在一定程度上改善患者的预后，但治疗过程中存在较多并发症，因而难以继续推广[2]。目前经皮冠状动脉介入(percutaneous coronary intervention，PCI)的发展为治疗CHD带来了新的突破，但就PCI对CHD患者炎症因子的影响的研究鲜少报道。为此，我院进一步探讨了PCI治疗CHD的疗效及对患者血清炎症因子的影响，现将结果报道如下。, 百拇医药(毛红岩)