盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响(1)
摘 要：目的 探讨盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者的氧化应激、心肌功能的影响。方法 选择我院心内科2016年6月～2017年6月80例冠心病伴心力衰竭患者，按照随机数字表法分为传统组与辅助组，每组40例，传统组患者给予常规治疗，辅助组患者在常规治疗基础上给予盐酸曲美他嗪片辅助治疗，对比两组患者治疗后LVEF、SO、LVESD、LVEDD、MDA水平。结果 辅助组患者治疗后LVEF(58.1±7.5)%、SOD(120.2±15.8)U/ml较传统组(51.2±6.5)%、(84.2±12.4)U/ml升高，LVESD(44.8±4.2)mm、LVEDD(31.2±3.3)mm、MDA(6.2±1.3)μmol/L较传统组(48.2±4.6)mm、(35.4±3.5)mm、(8.6±1.5)μmol/L降低，差异有统计学意义(P<0.05)。结论 盐酸曲美他嗪片辅助治疗冠心病伴心力衰竭患者可改善患者氧化应激状况，提升患者心肌功能。
关键词：冠心病；心力衰竭；盐酸曲美他嗪片；氧化应激；心肌功能
, 百拇医药
中图分类号：R541.4；R541.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.041
文章编号：1006-1959(2018)10-0126-03
Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure
LI Duo，WANG Jian-hua
(Department of Cardiology，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China)
, 百拇医药
Abstract：Objective To investigate the effects of adjuvant trimetazole hydrochloride on oxidative stress and myocardial function in patients with coronary heart disease complicated with heart failure.Methods From June 2016 to June 2017，80 patients with coronary heart disease complicated with heart failure in our hospital were divided into two groups：the traditional group(40 cases)and the auxiliary group(40 cases).The patients in the traditional group were treated with routine therapy.The patients in the adjuvant group were given trimetazidine hydrochloride on the basis of routine treatment，the levels of LVEF，SO，LVESD，LVEDD and MDA were compared between the two groups after treatment.Results After treatment，LVEF(58.1±7.5)%and SOD(120.2±15.8)U/ml in the adjuvant group were higher than those in the traditional group(51.2±6.5)%and(84.2±12.4)U/ml，and the LVESD was(44.8±4.2)mm. LVEDD(31.2±3.3)mm，MDA(6.2±1.3)μmol/L decreased compared with the traditional group(48.2±4.6)mm，(35.4±3.5)mm，(8.6±1.5) μmol/L，the difference was statistically significant(P<0.05).Conclusion Trimetazidine hydrochloride tablets adjuvant treatment of coronary heart disease complicated with heart failure can improve the patient's oxidative stress，improve myocardial function.
, 百拇医药
Key words：Coronary heart disease；Heart failure；Trimetazidine hydrochloride tablets；Oxidative stress；Myocardial function
冠狀动脉性心脏病(coronary artery heart disease， CHD)，简称冠心病，是临床最常发的慢性心血管疾病类型。心力衰竭是多种心脏疾病的终末期，心力衰竭致死率较高，且临床研究发现冠心病是引起心力衰竭发生的主要因素，而心力衰竭也是引起冠心病患者死亡的重要因素[1]。因此，临床对于冠心病伴心力衰竭需实施早期治疗，及时改善患者心肌功能，减少患者死亡率。盐酸曲美他嗪片是目前临床常用抗心绞痛药物，在冠心病患者治疗中的运用逐渐增多[2]。本科室对2016年6月～2017年6月40例冠心病伴心力衰竭患者给予盐酸曲美他嗪片辅助治疗，现分析如下。, http://www.100md.com(李铎 王建华)
关键词：冠心病；心力衰竭；盐酸曲美他嗪片；氧化应激；心肌功能
, 百拇医药
中图分类号：R541.4；R541.6 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.10.041
文章编号：1006-1959(2018)10-0126-03
Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure
LI Duo，WANG Jian-hua
(Department of Cardiology，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China)
, 百拇医药
Abstract：Objective To investigate the effects of adjuvant trimetazole hydrochloride on oxidative stress and myocardial function in patients with coronary heart disease complicated with heart failure.Methods From June 2016 to June 2017，80 patients with coronary heart disease complicated with heart failure in our hospital were divided into two groups：the traditional group(40 cases)and the auxiliary group(40 cases).The patients in the traditional group were treated with routine therapy.The patients in the adjuvant group were given trimetazidine hydrochloride on the basis of routine treatment，the levels of LVEF，SO，LVESD，LVEDD and MDA were compared between the two groups after treatment.Results After treatment，LVEF(58.1±7.5)%and SOD(120.2±15.8)U/ml in the adjuvant group were higher than those in the traditional group(51.2±6.5)%and(84.2±12.4)U/ml，and the LVESD was(44.8±4.2)mm. LVEDD(31.2±3.3)mm，MDA(6.2±1.3)μmol/L decreased compared with the traditional group(48.2±4.6)mm，(35.4±3.5)mm，(8.6±1.5) μmol/L，the difference was statistically significant(P<0.05).Conclusion Trimetazidine hydrochloride tablets adjuvant treatment of coronary heart disease complicated with heart failure can improve the patient's oxidative stress，improve myocardial function.
, 百拇医药
Key words：Coronary heart disease；Heart failure；Trimetazidine hydrochloride tablets；Oxidative stress；Myocardial function
冠狀动脉性心脏病(coronary artery heart disease， CHD)，简称冠心病，是临床最常发的慢性心血管疾病类型。心力衰竭是多种心脏疾病的终末期，心力衰竭致死率较高，且临床研究发现冠心病是引起心力衰竭发生的主要因素，而心力衰竭也是引起冠心病患者死亡的重要因素[1]。因此，临床对于冠心病伴心力衰竭需实施早期治疗，及时改善患者心肌功能，减少患者死亡率。盐酸曲美他嗪片是目前临床常用抗心绞痛药物，在冠心病患者治疗中的运用逐渐增多[2]。本科室对2016年6月～2017年6月40例冠心病伴心力衰竭患者给予盐酸曲美他嗪片辅助治疗，现分析如下。, http://www.100md.com(李铎 王建华)