体表胃起搏治疗顽固性胃功能性消化不良的临床效果观察(1)
摘 要：目的 觀察体表胃肠起搏治疗顽固性胃功能性消化不良的有效性与安全性，为临床推广应用奠定基础。方法 选取2016年1月～2017年12月我院消化科门诊经药物治疗无效的顽固性胃功能性消化不良患者60例，采用WCH型胃肠起搏器进行治疗，同时选择身体健康的年龄与性别相对应的志愿者60例作为正常对照组。比较治疗前后的临床症状有效率、临床症状积分、胃电图参数、4 h胃排空率及不良反应等。结果 治疗后症状总积分为(4.4±2.1)分，低于治疗前的(6.9±2.7)分，差异具有统计学意义(P<0.05)；总症状改善率为32.29%；对于餐后饱胀、嗳气、恶心、呕吐、早饱、返酸的有效率分别为51.02%、61.29%、24.32%、20.00%、69.44%、36.36%。治疗前患者餐前餐后各项胃电参数均低于正常对照组，差异有统计学意义(P<0.05)，其中治疗前餐前DF(cpm)、DP%、N%、C%，餐后C%更为显著(P<0.01)。给予治疗后，DF(cpm)、N%餐前餐后提高(P<0.05)。患者治疗前4 h胃排空率低于正常对照组，差异具有统计学意义(P<0.05)，给予治疗后胃排空率提高，差异具有统计学意义(P<0.05)。整个治疗过程中无不良反应发生。结论 对于药物治疗无效的顽固性胃功能性消化不良患者，采用体表胃起搏治疗可有效缓解患者症状，改善部分胃电参数，提高胃排空功能。
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关键词：体表胃起搏；功能性消化不良；胃排空
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.003
文章编号：1006-1959(2018)11-0008-04
Clinical Effect of Body Surface Gastric Pacing on Intractable Gastric Functional Dyspepsia
YE Jun，WEI Xue-mei，CHEN Ling，JIE Xiao-ming
(Department of Gastroenterology，324th Hospital of PLA，Chongqing 400020，China)
, 百拇医药
Abstract：Objective To observe the efficacy and safety of body surface gastrointestinal pacing in the treatment of refractory gastric functional dyspepsia，so as to lay a foundation for clinical application.Methods Select 60 patients with intractable gastric functional dyspepsia who were not treated with drugs in our department of gastroenterology from January 2016 to December 2017，and use the WCH type gastrointestinal pacemaker for treatment.At the same time，select the age and sex of physical health.The corresponding volunteers were used as normal controls in 60 cases.The efficacy of clinical symptoms before and after treatment，clinical symptom score，electrogastrogram parameters，4h gastric emptying rate，and adverse reactions were compared.Results The total score of symptoms after treatment was(4.4±2.1)points，which was lower than that before treatment(6.9±2.7)points，the difference was statistically significant(P<0.05)；the overall symptom improvement rate was 32.29%；The effective rates for postprandial fullness，belching，nausea， vomiting，early satiety，and acid reflux were 51.02%，61.29%，24.32%，20.00%，69.44%and 36.36%，respectively.The pre-prandial postprandial electrogastrogram parameters were lower than those in the normal control group before treatment，the difference was statistically significant (P<0.05)，before treatment，among which pre-meal DF(cpm)，DP%，N%，C%，and postprandial C% were more significant(P<0.01).After treatment，DF(cpm)and N% preprandial meal increased(P<0.05).The patient's gastric emptying rate 4h before treatment was lower than that of the normal control group，the difference was statistically significant(P<0.05)，and the gastric emptying rate was increased after treatment，the difference was statistically significant(P<0.05).No adverse reactions occurred throughout the course of treatment.Conclusion For patients with intractable gastric functional dyspepsia who are ineffective for drug treatment，the use of surface gastric pacing therapy can effectively relieve the symptoms of patients，improve some of the gastric electrical parameters，and improve gastric emptying., 百拇医药(叶钧 魏雪梅 陈陵 揭晓明)
, http://www.100md.com
关键词：体表胃起搏；功能性消化不良；胃排空
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.003
文章编号：1006-1959(2018)11-0008-04
Clinical Effect of Body Surface Gastric Pacing on Intractable Gastric Functional Dyspepsia
YE Jun，WEI Xue-mei，CHEN Ling，JIE Xiao-ming
(Department of Gastroenterology，324th Hospital of PLA，Chongqing 400020，China)
, 百拇医药
Abstract：Objective To observe the efficacy and safety of body surface gastrointestinal pacing in the treatment of refractory gastric functional dyspepsia，so as to lay a foundation for clinical application.Methods Select 60 patients with intractable gastric functional dyspepsia who were not treated with drugs in our department of gastroenterology from January 2016 to December 2017，and use the WCH type gastrointestinal pacemaker for treatment.At the same time，select the age and sex of physical health.The corresponding volunteers were used as normal controls in 60 cases.The efficacy of clinical symptoms before and after treatment，clinical symptom score，electrogastrogram parameters，4h gastric emptying rate，and adverse reactions were compared.Results The total score of symptoms after treatment was(4.4±2.1)points，which was lower than that before treatment(6.9±2.7)points，the difference was statistically significant(P<0.05)；the overall symptom improvement rate was 32.29%；The effective rates for postprandial fullness，belching，nausea， vomiting，early satiety，and acid reflux were 51.02%，61.29%，24.32%，20.00%，69.44%and 36.36%，respectively.The pre-prandial postprandial electrogastrogram parameters were lower than those in the normal control group before treatment，the difference was statistically significant (P<0.05)，before treatment，among which pre-meal DF(cpm)，DP%，N%，C%，and postprandial C% were more significant(P<0.01).After treatment，DF(cpm)and N% preprandial meal increased(P<0.05).The patient's gastric emptying rate 4h before treatment was lower than that of the normal control group，the difference was statistically significant(P<0.05)，and the gastric emptying rate was increased after treatment，the difference was statistically significant(P<0.05).No adverse reactions occurred throughout the course of treatment.Conclusion For patients with intractable gastric functional dyspepsia who are ineffective for drug treatment，the use of surface gastric pacing therapy can effectively relieve the symptoms of patients，improve some of the gastric electrical parameters，and improve gastric emptying., 百拇医药(叶钧 魏雪梅 陈陵 揭晓明)