丙戊酸钠联合拉莫三嗪治疗脑卒中继发性癫痫的效果观察(1)
摘 要：目的 探索丙戊酸钠联合拉莫三嗪在脑卒中继发性癫痫治疗中的应用效果。方法 选择2015年10月～2017年10月我院神经内科所收治的100例脑卒中继发性癫痫患者为研究对象，按照数字随机法将患者分为实验组与对照组，每组50例。对照组中的患者给予口服丙戊酸钠基础治疗，实验组在对照组的基础之上给予拉莫三嗪治疗；对两组患者的治疗有效率以及脑电图变化进行统计对比；结果 对照组患者治疗有效率为78.00%，低于实验组98.00%，差异有统计学意义(P<0.05)；实验组中患者在治疗1年后的痫样放电水平为(7.2±3.5)/180 s，对照组中患者的在治疗1年后的痫样放电水平为(12.3±6.5)/180 s；实验组中患者在治疗1年后的累及导联数水平为(3.3±2.2)/180 s，对照组中患者的在治疗1年后的累及导联数水平为(5.4±3.8)/180 s。实验组优于对照组中的患者，差异有统计学意义(P<0.05)。结论 继发性癫痫中应用丙戊酸钠联合拉莫三嗪可以提高临床治疗效果，改善患者的癫痫症状，具有较好的临床治疗效果。
关键词：丙戊酸钠；拉莫三嗪；脑卒中继发性癫痫
, http://www.100md.com
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.040
文章编号：1006-1959(2018)11-0127-03
Effect of Sodium Valproate Combined with Lamotrigine in the Treatment of Secondary Post-stroke Epilepsy
HU Qing-ting
(Department of Neurology，Huai'an Hospital，Huai'an 223200，Jiangsu，China)
Abstract：Objective To explore the effect of sodium valproate combined with lamotrigine in the treatment of secondary epilepsy after stroke.Methods From October 2015 to October 2017，100 patients with secondary epilepsy after stroke were randomly divided into experimental group and control group with 50 cases in each group.The patients in the control group were treated with basic oral sodium valproate，the experimental group was treated with lamotrigine on the basis of the control group，the effective rate of treatment and the changes of EEG in the two groups were compared statistically.Results The effective rate of treatment in the control group was 78.00%，which was lower than 98.00% in the experimental group，the difference was statistically significant(P<0.05)；the epileptic discharge in the experimental group was(7.2±3.5)/180s after 1 year of treatment，and the epileptic discharge level of the patient in the control group after 1 year of treatment.It was(12.3±6.5)/180s；the patients in the experimental group had(3.3±2.2)/180s of the number of culprit leads after 1 year of treatment，the number of patients with compulsive leads after 1 year of treatment in the control group was (5.4±3.8)/180s.The experimental group was better than the control group，and the difference was statistically significant(P<0.05). Conclusion The use of sodium valproate combined with lamotrigine in the treatment of secondary epilepsy can improve the clinical effect and improve the patient's epilepsy symptoms.It has a good clinical effect.
, 百拇医药
Key words：Sodium valproate；Lamotrigine；Secondary post-stroke epilepsy
继发性癫痫是脑卒中患者的一种常见并发症，同时也是老年人癫痫的重要诱因，根据临床统计结果现实，在中老年脑卒中患者群体当中大约有15%～20%左右的患者会出现继发性癫痫并发症，如何合理用药进行治疗已经成为临床医师必须要面临的重要问题。临床上对继发性癫痫多采用短期服药，其中迟发型癫痫优于病灶清除较难多长期服药。在临床用药上，选用的多为卡马西平和丙戊酸钠等安全性较高，副作用较低的药物，且发现单药治疗的临床效果不佳，并不能达到较好的治疗效果。基于此种情况，本文选择2015年10月～2017年10月我院神经内科所收治的100例脑卒中继发性癫痫患者为本文的研究对象，进一步探索丙戊酸钠联合拉莫三嗪在腦卒中继发性癫痫治疗中的效果，现报道如下。, http://www.100md.com(胡青婷)
关键词：丙戊酸钠；拉莫三嗪；脑卒中继发性癫痫
, http://www.100md.com
中图分类号：R743.3 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.11.040
文章编号：1006-1959(2018)11-0127-03
Effect of Sodium Valproate Combined with Lamotrigine in the Treatment of Secondary Post-stroke Epilepsy
HU Qing-ting
(Department of Neurology，Huai'an Hospital，Huai'an 223200，Jiangsu，China)
Abstract：Objective To explore the effect of sodium valproate combined with lamotrigine in the treatment of secondary epilepsy after stroke.Methods From October 2015 to October 2017，100 patients with secondary epilepsy after stroke were randomly divided into experimental group and control group with 50 cases in each group.The patients in the control group were treated with basic oral sodium valproate，the experimental group was treated with lamotrigine on the basis of the control group，the effective rate of treatment and the changes of EEG in the two groups were compared statistically.Results The effective rate of treatment in the control group was 78.00%，which was lower than 98.00% in the experimental group，the difference was statistically significant(P<0.05)；the epileptic discharge in the experimental group was(7.2±3.5)/180s after 1 year of treatment，and the epileptic discharge level of the patient in the control group after 1 year of treatment.It was(12.3±6.5)/180s；the patients in the experimental group had(3.3±2.2)/180s of the number of culprit leads after 1 year of treatment，the number of patients with compulsive leads after 1 year of treatment in the control group was (5.4±3.8)/180s.The experimental group was better than the control group，and the difference was statistically significant(P<0.05). Conclusion The use of sodium valproate combined with lamotrigine in the treatment of secondary epilepsy can improve the clinical effect and improve the patient's epilepsy symptoms.It has a good clinical effect.
, 百拇医药
Key words：Sodium valproate；Lamotrigine；Secondary post-stroke epilepsy
继发性癫痫是脑卒中患者的一种常见并发症，同时也是老年人癫痫的重要诱因，根据临床统计结果现实，在中老年脑卒中患者群体当中大约有15%～20%左右的患者会出现继发性癫痫并发症，如何合理用药进行治疗已经成为临床医师必须要面临的重要问题。临床上对继发性癫痫多采用短期服药，其中迟发型癫痫优于病灶清除较难多长期服药。在临床用药上，选用的多为卡马西平和丙戊酸钠等安全性较高，副作用较低的药物，且发现单药治疗的临床效果不佳，并不能达到较好的治疗效果。基于此种情况，本文选择2015年10月～2017年10月我院神经内科所收治的100例脑卒中继发性癫痫患者为本文的研究对象，进一步探索丙戊酸钠联合拉莫三嗪在腦卒中继发性癫痫治疗中的效果，现报道如下。, http://www.100md.com(胡青婷)