伴中央颞区棘波的儿童良性癫痫与微量元素的关系研究(1)
摘 要：目的 分析伴中央颞区棘波的儿童良性癫痫与微量元素的相关性，探讨BECT的病因及发病机制。方法 选择在本院就诊的45例BECT患儿作为实验组，选择同一时间段来我院体检的儿童50例作为对照组。实验组儿童在首次惊厥发作24 h内给予抗癫痫药治疗前，对照组儿童在健康体检时，均抽取5 ml静脉血置于一次性使用生化采血管，采用BH5300S型钨舟原子吸收光谱仪检测全血微量元素浓度，分析比较两组儿童血清微量元素水平。结果 实验组血清锌含量为(6.80±1.93)mmol/L，低于对照组的(8.60±1.07)mmol/L，统计学意义显著(P<0.01)。实验组血清铁含量为(4.20±1.32)mmol/L，低于对照组的(7.40±1.26) mmol/L，统计学意义显著(P<0.01)。实验组血清铜含量为(15.80±2.10)mmol/L，与对照组(16.20±2.44)mmol/L比较，差异无统计学意义(P>0.05)。结论 BECT患儿存在微量元素铁、锌减少，为临床工作者进一步研究BECT的病因及发病机制，提供了一个新的靶点。
, http://www.100md.com 关键词：中央颞区棘波；癫痫；儿童；微量元素
中图分类号：R742.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.027
文章编号：1006-1959(2018)12-0090-03
Abstract：Objective To analyze the relationship between benign epilepsy and trace elements in children with central temporal spikes，and to explore the etiology and pathogenesis of BECT.Methods 45 BECT children in our hospital were selected as experimental group and 50 children in the same time period as control group.Children in the experimental group were treated with antiepileptic drugs within 24 hours after the first convulsion attack，and the control group children were collected 5 ml venous blood at the time of physical examination and placed in a single use of biochemical blood vessels.The concentration of trace elements in whole blood was determined by BH 5300S tungsten boat atomic absorption spectrometer，and the serum trace element levels of the two groups were analyzed and compared.Results The serum zinc concentration in the experimental group was(6.80±1.93)mmol/L，which was lower than that in the control group(8.60±1.07)mmol/L，with statistical significance(P<0.01).The serum iron content in the experimental group was(4.20±1.32)mmol/L，which was lower than that in the control group(7.40±1.26)mmol/L，with statistical significance(P<0.01).The serum copper level in the experimental group was(15.80±2.10)mmol/L，which was not statistically different from that in the control group(16.20±2.44)mmol/L(P>0.05).Conclusion There is a decrease in trace elements iron and zinc in children with BECT，which provides a new target for clinicians to further study the etiology and pathogenesis of BECT.
, 百拇医药
Key words：Central temporal spikes；Epilepsy；Children；Trace elements
伴中央颞区棘波的儿童良性癫痫(BECT)是儿童良性局灶性癫痫最常见的一种类型，出现痫性发作的年龄为2～15岁，痫性发作与睡眠中的浅睡期关系尤为密切，绝大多数在夜间刚入睡后不久发作，发作形式主要为部分性发作，也可全身泛化而致癥状加重。每次发作时间长短不一，可以发作几秒钟而致临床不易发现，也可以发作几分钟，甚至可以出现癫痫持续状态。大多数患病儿童预后良好，但临床上也存在变异型，表现比较复杂，脑电图癫痫放电明显增多，可出现癫痫性电持续状态，癫痫发作也明显增多，对认知功能会产生一定影响，部分患儿可遗留认知功能障碍[1]。一些学者认为微量元素与人体神经系统功能稳定有关，是维持人体神经系统功能稳定必需的物质，微量元素的缺乏会导致大脑神经细胞异常放电或抑制正常放电。儿童的大脑处于生长发育过程中，对营养的需求较高，体内环境的微小改变都可成为其发作诱因[2]。本研究通过对45例BECT患儿末梢血中某些微量元素的测定，分析BECT与微量元素之间的关系，为临床防治本病开辟一条新思路。, http://www.100md.com(李振宏 施海龙 林思名 祝鹏宇 邓任辉)
, http://www.100md.com 关键词：中央颞区棘波；癫痫；儿童；微量元素
中图分类号：R742.1 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.027
文章编号：1006-1959(2018)12-0090-03
Abstract：Objective To analyze the relationship between benign epilepsy and trace elements in children with central temporal spikes，and to explore the etiology and pathogenesis of BECT.Methods 45 BECT children in our hospital were selected as experimental group and 50 children in the same time period as control group.Children in the experimental group were treated with antiepileptic drugs within 24 hours after the first convulsion attack，and the control group children were collected 5 ml venous blood at the time of physical examination and placed in a single use of biochemical blood vessels.The concentration of trace elements in whole blood was determined by BH 5300S tungsten boat atomic absorption spectrometer，and the serum trace element levels of the two groups were analyzed and compared.Results The serum zinc concentration in the experimental group was(6.80±1.93)mmol/L，which was lower than that in the control group(8.60±1.07)mmol/L，with statistical significance(P<0.01).The serum iron content in the experimental group was(4.20±1.32)mmol/L，which was lower than that in the control group(7.40±1.26)mmol/L，with statistical significance(P<0.01).The serum copper level in the experimental group was(15.80±2.10)mmol/L，which was not statistically different from that in the control group(16.20±2.44)mmol/L(P>0.05).Conclusion There is a decrease in trace elements iron and zinc in children with BECT，which provides a new target for clinicians to further study the etiology and pathogenesis of BECT.
, 百拇医药
Key words：Central temporal spikes；Epilepsy；Children；Trace elements
伴中央颞区棘波的儿童良性癫痫(BECT)是儿童良性局灶性癫痫最常见的一种类型，出现痫性发作的年龄为2～15岁，痫性发作与睡眠中的浅睡期关系尤为密切，绝大多数在夜间刚入睡后不久发作，发作形式主要为部分性发作，也可全身泛化而致癥状加重。每次发作时间长短不一，可以发作几秒钟而致临床不易发现，也可以发作几分钟，甚至可以出现癫痫持续状态。大多数患病儿童预后良好，但临床上也存在变异型，表现比较复杂，脑电图癫痫放电明显增多，可出现癫痫性电持续状态，癫痫发作也明显增多，对认知功能会产生一定影响，部分患儿可遗留认知功能障碍[1]。一些学者认为微量元素与人体神经系统功能稳定有关，是维持人体神经系统功能稳定必需的物质，微量元素的缺乏会导致大脑神经细胞异常放电或抑制正常放电。儿童的大脑处于生长发育过程中，对营养的需求较高，体内环境的微小改变都可成为其发作诱因[2]。本研究通过对45例BECT患儿末梢血中某些微量元素的测定，分析BECT与微量元素之间的关系，为临床防治本病开辟一条新思路。, http://www.100md.com(李振宏 施海龙 林思名 祝鹏宇 邓任辉)