体重指数对多囊卵巢综合征患者人工授精妊娠结局影响(1)
摘 要：目的 研究体重指数对于多囊卵巢综合征患者宫腔内人工授精的妊娠结局的影响。方法 选取2017年1月～2018年1月在鄂东医疗集团黄石市中心医院生殖中心进行宫腔内人工授精的PCOS患者154例，根据体重指数分为对照组89例及观察组65例，对照组为正常体重组，观察组为肥胖组，两组患者均采取促排卵治疗，比较两组患者促排卵药物的使用剂量，促排卵天数，成熟卵泡个数、雌激素水平、卵巢过度刺激综合征的发生率及妊娠率。结果 对照组促排卵药物的使用剂量225 U、促排卵天数(6.41±1.36)d、成熟卵泡个数(1.8±0.9)个、单卵泡雌激素水平(189.61±25.83)pg/ml及妊娠率23.59%，优于观察组450 U、(7.26±2.19)d、(1.5±1.1)个、(178.34±33.52)pg/ml、16.92%，差异有统计学意义(P<0.05)。结论 通过降低体重、减少体重指数，可降低PCOS患者体内胰岛素水平及睾酮水平，改善代谢及生殖系统异常，减少促排卵药物使用剂量及使用时间，提高患者的临床妊娠率。
关键词：多囊卵巢综合征；体重指数；促排卵；宫腔内人工授精；妊娠率
, http://www.100md.com
中图分类号：R714.7 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.030
文章编号：1006-1959(2018)12-0099-03
Abstract：Objective To study the effect of body mass index on the pregnancy outcome of intrauterm insemination in patients with polycystic ovary syndrome.Methods 154 patients with PCOS who underwent intrauterm insemination from January 2017 to January 2018 at the reproduction center of Huangshi Central Hospital of Hubei East Medical Group were selected.According to the body mass index，there were 89 cases in the control group and 65 cases in the observation group.The control group was normal body reconstitution，and the observation group was obese group.Both groups were treated with ovulation induction.The doses of ovulation-promoting drugs，the number of ovulation induction days，the number of mature follicles，the level of estrogen，the incidence of ovarian hyperstimulation syndrome，and the pregnancy rate were compared between the two groups.Results The doses of ovulation induction drugs in control group were 225U，days of ovulation induction(6.41±1.36)d，number of mature follicles(1.8±0.9)，single follicle estrogen levels(189.61±25.83)pg/ml，and pregnancy rate 23.59%.Compared with the observation group 450U，(7.26±2.19)d，(1.5±1.1)，(178.34±33.52)pg/ml，and 16.92%，the difference was statistically significant(P<0.05).Conclusion By reducing body weight and reducing body mass index，the level of insulin and testosterone in PCOS patients can be reduced，abnormality of metabolic and reproductive system can be improved，the dosage and time of use of ovulating drugs can be reduced，and the clinical pregnancy rate of patients is improved.
, 百拇医药
Key words：Polycystic ovary syndrome；Body mass index；Ovulation induction；Intrauterm insemination；Pregnancy rate
多囊卵巢綜合征(polycystic ovary syndrome，PCOS)是育龄女性常见的生殖内分泌代谢性疾病，其发病率高达5%～10%[1]。临床症状为月经失调、不孕症、肥胖和痤疮。其病理生理特点为高雄激素血症、高胰岛素血症、胰岛素抵抗(insulin resistance，IR)以及卵巢多囊样改变等[2]。其中肥胖是部分PCOS患者的重要临床症状，肥胖患者容易产生IR，对促排卵治疗反应较差，对于输卵管通畅的PCOS患者经过多次单纯促排卵治疗未孕时多建议行宫腔内人工授精(intrauterm insemination，IUI)助孕。本研究旨在研究体重指数(body mass index，BMI)对PCOS患者IUI妊娠结局的影响，具体报道如下。, http://www.100md.com(袁奔 潘伟 罗淑红 罗燕 毛俊彪)
关键词：多囊卵巢综合征；体重指数；促排卵；宫腔内人工授精；妊娠率
, http://www.100md.com
中图分类号：R714.7 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.030
文章编号：1006-1959(2018)12-0099-03
Abstract：Objective To study the effect of body mass index on the pregnancy outcome of intrauterm insemination in patients with polycystic ovary syndrome.Methods 154 patients with PCOS who underwent intrauterm insemination from January 2017 to January 2018 at the reproduction center of Huangshi Central Hospital of Hubei East Medical Group were selected.According to the body mass index，there were 89 cases in the control group and 65 cases in the observation group.The control group was normal body reconstitution，and the observation group was obese group.Both groups were treated with ovulation induction.The doses of ovulation-promoting drugs，the number of ovulation induction days，the number of mature follicles，the level of estrogen，the incidence of ovarian hyperstimulation syndrome，and the pregnancy rate were compared between the two groups.Results The doses of ovulation induction drugs in control group were 225U，days of ovulation induction(6.41±1.36)d，number of mature follicles(1.8±0.9)，single follicle estrogen levels(189.61±25.83)pg/ml，and pregnancy rate 23.59%.Compared with the observation group 450U，(7.26±2.19)d，(1.5±1.1)，(178.34±33.52)pg/ml，and 16.92%，the difference was statistically significant(P<0.05).Conclusion By reducing body weight and reducing body mass index，the level of insulin and testosterone in PCOS patients can be reduced，abnormality of metabolic and reproductive system can be improved，the dosage and time of use of ovulating drugs can be reduced，and the clinical pregnancy rate of patients is improved.
, 百拇医药
Key words：Polycystic ovary syndrome；Body mass index；Ovulation induction；Intrauterm insemination；Pregnancy rate
多囊卵巢綜合征(polycystic ovary syndrome，PCOS)是育龄女性常见的生殖内分泌代谢性疾病，其发病率高达5%～10%[1]。临床症状为月经失调、不孕症、肥胖和痤疮。其病理生理特点为高雄激素血症、高胰岛素血症、胰岛素抵抗(insulin resistance，IR)以及卵巢多囊样改变等[2]。其中肥胖是部分PCOS患者的重要临床症状，肥胖患者容易产生IR，对促排卵治疗反应较差，对于输卵管通畅的PCOS患者经过多次单纯促排卵治疗未孕时多建议行宫腔内人工授精(intrauterm insemination，IUI)助孕。本研究旨在研究体重指数(body mass index，BMI)对PCOS患者IUI妊娠结局的影响，具体报道如下。, http://www.100md.com(袁奔 潘伟 罗淑红 罗燕 毛俊彪)