冠脉介入治疗对冠心病急性心肌梗死患者心肌损伤及心室重塑的影响(1)
摘 要：目的 观察冠脉介入治疗对冠心病急性心肌梗死患者心肌损伤及心室重塑的影响。方法 选取我院自2017年9月～12月收治的64例冠心病急性心肌梗死患者作为观察对象，随机分为研究组33例和对照组31例。对照组给予吸氧、镇静、对症治疗，并给予氯吡格雷+阿司匹林口服，研究组在此基础上进行冠脉介入治疗，对比两组CK、CK-MB、BNP及LVEF、LFESV、LVEDV变化情况。结果 在治疗3 d、7 d后，研究组BNP水平均低于对照组，差异有统计学意义(P<0.05)。研究组CK峰值、CK-MB峰值与对照组比较，差异无统计学意义(P>0.05)，但研究组CK峰值、CK-MB峰值出现时间均短于对照组，差异有统计学意义(P<0.05)。治疗7 d后，两组患者LVEF均升高，LFESV、LVEDV均降低，且研究组LVEF高于对照组，LFESV、LVEDV低于对照组，差异均有统计学意义(P<0.05)。结论 冠脉介入治疗冠心病急性心肌梗死患者可降低患者BNP水平，改善患者心肌损伤，促进心室重塑，具有較高的应用价值。
关键词：冠脉介入；急性心肌梗死；CK-MB；BNP；心室重塑
, 百拇医药
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.031
文章编号：1006-1959(2018)12-0102-03
Abstract：Objective To observe the effects of coronary intervention on myocardial injury and ventricular remodeling in patients with acute myocardial infarction.Methods 64 patients with acute myocardial infarction of coronary heart disease from September 2017 to December 2017 were randomly divided into study group 33 cases and control group 31 cases.The control group was given oxygen inhalation， sedative，symptomatic treatment and oral Clopidogrel+Aspirin；The study group was treated with coronary intervention on the basis of this，and the changes of CK，CK-MB，BNP and LVEF，LFESV，LVEDV were compared in the two groups.Results After 3d and 7d of treatment，the levels of BNP in the study group were significantly lower than those in the control group，the difference was statistically significant(P<0.05).There was no significant difference in the peak value of CK and CK-MB between the study group and the control group(P>0.05)，but the time of the peak value of CK and CK-MB in the study group was shorter than that in the control group，the difference was statistically significant(P<0.05).After 7d treatment，the two groups were all increased，LFESV，LVEDV decreased，and the study group LVEF was higher than the control group，LFESV and LVEDV were lower than the control group，the difference was statistically significant(P<0.05).Conclusion Coronary intervention in patients with acute myocardial infarction can reduce the level of BNP，improve the myocardial injury and promote ventricular remodeling，which has a high value of application.
, http://www.100md.com
Key words：Coronary intervention；Acute Myocardial Infarction；CK-MB；BNP；Ventricular remodeling
冠心病急性心肌梗死属于常见疾病，病情进展快，同时容易并发心源性休克、心衰等，威胁患者生命安全[1]。临床上对冠心病急性心肌梗死的治疗有药物保守治疗、冠脉介入、溶栓治疗等。其中冠脉介入是常用的治疗措施，其能够快速恢复冠脉灌注，改善局部循环，减轻心肌损伤，进而改善患者的预后。B型钠利尿肽(BNP)属于神经激素类物质，其主要通过心室合成和分泌，在评价心血管事件病情中具有重要价值[2]。相关研究[3]表明，BNP在PCI治疗急性心肌梗死患者中具有评估预后的重要作用。在此背景下，本研究主要探讨冠脉介入治疗对冠心病急性心肌梗死患者CK、CK-MB、BNP及心室重塑的影响，现报告如下。, 百拇医药(毛红岩 宁国贤)
关键词：冠脉介入；急性心肌梗死；CK-MB；BNP；心室重塑
, 百拇医药
中图分类号：R541.4 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.031
文章编号：1006-1959(2018)12-0102-03
Abstract：Objective To observe the effects of coronary intervention on myocardial injury and ventricular remodeling in patients with acute myocardial infarction.Methods 64 patients with acute myocardial infarction of coronary heart disease from September 2017 to December 2017 were randomly divided into study group 33 cases and control group 31 cases.The control group was given oxygen inhalation， sedative，symptomatic treatment and oral Clopidogrel+Aspirin；The study group was treated with coronary intervention on the basis of this，and the changes of CK，CK-MB，BNP and LVEF，LFESV，LVEDV were compared in the two groups.Results After 3d and 7d of treatment，the levels of BNP in the study group were significantly lower than those in the control group，the difference was statistically significant(P<0.05).There was no significant difference in the peak value of CK and CK-MB between the study group and the control group(P>0.05)，but the time of the peak value of CK and CK-MB in the study group was shorter than that in the control group，the difference was statistically significant(P<0.05).After 7d treatment，the two groups were all increased，LFESV，LVEDV decreased，and the study group LVEF was higher than the control group，LFESV and LVEDV were lower than the control group，the difference was statistically significant(P<0.05).Conclusion Coronary intervention in patients with acute myocardial infarction can reduce the level of BNP，improve the myocardial injury and promote ventricular remodeling，which has a high value of application.
, http://www.100md.com
Key words：Coronary intervention；Acute Myocardial Infarction；CK-MB；BNP；Ventricular remodeling
冠心病急性心肌梗死属于常见疾病，病情进展快，同时容易并发心源性休克、心衰等，威胁患者生命安全[1]。临床上对冠心病急性心肌梗死的治疗有药物保守治疗、冠脉介入、溶栓治疗等。其中冠脉介入是常用的治疗措施，其能够快速恢复冠脉灌注，改善局部循环，减轻心肌损伤，进而改善患者的预后。B型钠利尿肽(BNP)属于神经激素类物质，其主要通过心室合成和分泌，在评价心血管事件病情中具有重要价值[2]。相关研究[3]表明，BNP在PCI治疗急性心肌梗死患者中具有评估预后的重要作用。在此背景下，本研究主要探讨冠脉介入治疗对冠心病急性心肌梗死患者CK、CK-MB、BNP及心室重塑的影响，现报告如下。, 百拇医药(毛红岩 宁国贤)