普拉洛芬联合玻璃酸钠治疗眼科术后干眼症的疗效观察(1)
摘 要：目的 探讨普拉洛芬联合玻璃酸钠治疗眼科术后干眼症的临床疗效。方法 选取我院从2016年3月～2017年8月收治的86例眼科术后干眼症患者为研究对象，数字随机分为实验组42例与对照组44例，对照组以玻璃酸钠治疗，实验组以玻璃酸钠联合普拉洛芬治疗，比较两组泪液分泌试验、泪膜破裂试验及临床疗效。结果 治疗后实验组Schirmer试验(8.93±1.65)min及BUT(11.49±2.81)min，高于对照组(6.72±1.71)min、(9.21±2.48)min，差异有统计学意义(P<0.05)。实验组有效率95.23%，高于对照组77.27%，实验组治愈率42.86%，高于对照组25.00%，差异有统计学意义(P<0.05)。结论 普拉洛芬联合玻璃酸钠治疗眼科术后干眼症疗效佳，可作为眼科术后干眼症的常规治疗。
关键词：普拉洛芬；玻璃酸钠；干眼症
中图分类号：R779.66 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.043
, 百拇医药
文章编号：1006-1959(2018)12-0139-02
Abstract：Objective To investigate the clinical efficacy of pranoprofen combined with sodium hyaluronate in the treatment of xerophthalmia after ophthalmology.Methods 86 patients with ophthalmia after xerophthalmia from March 2016 to August 2017 in our hospital were selected as study subjects，the numbers were randomly divided into 42 cases in the experimental group and 44 cases in the control group.The control group was treated with sodium hyaluronate，and the experimental group was treated with sodium hyaluronate and pranoprofen.The tear secretion test，tear film rupture test and clinical efficacy were compared between the two groups.Results After treatment，Schirmer test(8.93±1.65)min and BUT(11.49±2.81)min were significantly higher in the experimental group than in the control group(6.72±1.71)min，(9.21±2.48)min，and the difference was statistically significant(P<0.05).The effective rate of the experimental group was 95.23%，which was higher than the control group of 77.27%.The cure rate of the experimental group was 42.86%，which was higher than that of the control group 25.00%，the difference was statistically significant(P<0.05).Conclusion The efficacy of pranoprofen combined with sodium hyaluronate in the treatment of xerophthalmia after ophthalmology is good，and it can be used as a routine treatment for xerophthalmia after ophthalmology.
, 百拇医药
Key words：Pranoprofen；Sodium hyaluronate；Xerophthalmia
干眼癥(xerophthalmia)指各种因素所致眼泪的质和量的异常[1]，进而出现眼睛干涩、眼痒、等症状[2]，严重者可出现角膜病变，最后进展为视力的下降直至失明。干眼症是眼科常见疾病之一，尤其对眼科手术的患者，术后干眼症的发生率有明显升高的趋势。干眼症的治疗一直是近年研究的热门领域。现在对于眼科术后干眼症的治疗，常规应用玻璃酸钠滴眼液，但其无法有效缓解患者术后眼部的炎症反应，因此越来越多的学者开始就如何更好地控制患者的炎症反应进行了进一步研究[3，4]。本次研究选自我院2016年3月～2017年8月收治的86例行眼科手术的术后干眼症患者，在玻璃酸钠治疗的基础上是否联用普拉洛芬，现分析如下。
1资料与方法
1.1 一般资料 所有研究对象均选自瓦房店第二医院2016年3月～2017年8月收治的86例行眼科手术的术后干眼症患者，本次研究经过医院伦理委员会批准。患者均存在不同程度的眼睛痒、眼红、灼伤感、异物感、眼睛干涩、视物模糊等症状，所有患者均符合干眼症的诊断标准：①眼膜破裂时间在10 s及以下；②泪液分泌试验在5 mm/5 min及以下；③角膜荧光素染色评分在1分及以上；以上条件满足≥2项者即可诊断。排除标准：①由其他原因导致的干眼症患者；②患有全身性疾病患者；③以及对本研究应用药物过敏的患者。按照数字随机原则分为实验组与对照组。实验组42例，其中男性22例，女性20例；年龄18～82岁，平均年龄(55.31±11.82)岁，病程11～38 d，平均病程(18.40±6.13)d 。对照组44例，其中男性23例，女性21例；年龄19～79岁，平均年龄(54.72±10.84)岁，病程10～40 d，平均病程(18.71±5.40)d。两组患者基本资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(王伟)
关键词：普拉洛芬；玻璃酸钠；干眼症
中图分类号：R779.66 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.12.043
, 百拇医药
文章编号：1006-1959(2018)12-0139-02
Abstract：Objective To investigate the clinical efficacy of pranoprofen combined with sodium hyaluronate in the treatment of xerophthalmia after ophthalmology.Methods 86 patients with ophthalmia after xerophthalmia from March 2016 to August 2017 in our hospital were selected as study subjects，the numbers were randomly divided into 42 cases in the experimental group and 44 cases in the control group.The control group was treated with sodium hyaluronate，and the experimental group was treated with sodium hyaluronate and pranoprofen.The tear secretion test，tear film rupture test and clinical efficacy were compared between the two groups.Results After treatment，Schirmer test(8.93±1.65)min and BUT(11.49±2.81)min were significantly higher in the experimental group than in the control group(6.72±1.71)min，(9.21±2.48)min，and the difference was statistically significant(P<0.05).The effective rate of the experimental group was 95.23%，which was higher than the control group of 77.27%.The cure rate of the experimental group was 42.86%，which was higher than that of the control group 25.00%，the difference was statistically significant(P<0.05).Conclusion The efficacy of pranoprofen combined with sodium hyaluronate in the treatment of xerophthalmia after ophthalmology is good，and it can be used as a routine treatment for xerophthalmia after ophthalmology.
, 百拇医药
Key words：Pranoprofen；Sodium hyaluronate；Xerophthalmia
干眼癥(xerophthalmia)指各种因素所致眼泪的质和量的异常[1]，进而出现眼睛干涩、眼痒、等症状[2]，严重者可出现角膜病变，最后进展为视力的下降直至失明。干眼症是眼科常见疾病之一，尤其对眼科手术的患者，术后干眼症的发生率有明显升高的趋势。干眼症的治疗一直是近年研究的热门领域。现在对于眼科术后干眼症的治疗，常规应用玻璃酸钠滴眼液，但其无法有效缓解患者术后眼部的炎症反应，因此越来越多的学者开始就如何更好地控制患者的炎症反应进行了进一步研究[3，4]。本次研究选自我院2016年3月～2017年8月收治的86例行眼科手术的术后干眼症患者，在玻璃酸钠治疗的基础上是否联用普拉洛芬，现分析如下。
1资料与方法
1.1 一般资料 所有研究对象均选自瓦房店第二医院2016年3月～2017年8月收治的86例行眼科手术的术后干眼症患者，本次研究经过医院伦理委员会批准。患者均存在不同程度的眼睛痒、眼红、灼伤感、异物感、眼睛干涩、视物模糊等症状，所有患者均符合干眼症的诊断标准：①眼膜破裂时间在10 s及以下；②泪液分泌试验在5 mm/5 min及以下；③角膜荧光素染色评分在1分及以上；以上条件满足≥2项者即可诊断。排除标准：①由其他原因导致的干眼症患者；②患有全身性疾病患者；③以及对本研究应用药物过敏的患者。按照数字随机原则分为实验组与对照组。实验组42例，其中男性22例，女性20例；年龄18～82岁，平均年龄(55.31±11.82)岁，病程11～38 d，平均病程(18.40±6.13)d 。对照组44例，其中男性23例，女性21例；年龄19～79岁，平均年龄(54.72±10.84)岁，病程10～40 d，平均病程(18.71±5.40)d。两组患者基本资料比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(王伟)