内科常规治疗联合床旁连续性肾脏替代疗法治疗急性重症胰腺炎的效果观察(1)
摘 要：目的 总结内科常规治疗联合床旁连续性肾脏替代疗法治疗急性重症胰腺炎的效果，为急性重症胰腺炎治疗工作提供参考。方法 选择我院2015年8月～2016年12月收治的72例SAP患者，以随机数字表法分为对照组和观察组，每组36例。对照组采取内科常规治疗，观察组联合CRRT治疗，对比两组SAP患者治疗期间ApacheⅡ评分、C反应蛋白、降钙素原、血TNF-a浓度等实验指标变化情况以及临床症状(腹痛、腹胀)缓解时间、ICU住院时间。结果 治疗后，观察组ApacheⅡ评分、C反应蛋白、降钙素原、血TNF-a浓度等临床指标均优于对照组，差异有统计学意义(P<0.05)。观察组腹痛、腹胀恢复时间分别为(18.50±6.50)h和(17.20±5.20)h，短于对照组的(85.05±5.60)h和(82.50±6.50)h，差异具有统计学意义(P<0.05)。观察组ICU住院时间为(7.55±3.50)d，短于对照组的(16.50±4.50)d，差异具有统计学意义(P<0.05)。结论 内科常规治疗基础上联合CRRT治疗SAP，可短时间改善患者症状、缩短患者住院时间，应用效果显著。
, http://www.100md.com
关键词：内科治疗；床旁连续性肾脏替代；急性重症胰腺炎；ICU住院时间
中图分类号：R576 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.13.031
文章编号：1006-1959(2018)13-0107-03
Abstract：Objective To summarize the effect of routine medical therapy combined with continuous bedside renal replacement therapy in the treatment of severe acute pancreatitis and to provide reference for the treatment of severe acute pancreatitis.Methods 72 patients with SAP from August 2015 to December 2016 in our hospital were randomly divided into control group and observation group with 36 cases in each group.The control group was treated with routine internal medicine，the observation group was treated with CRRT.The changes of experimental indexes such as Apache II score，C-reactive protein，procalcitonin and blood TNF-a concentration in the two groups of SAP patients were compared with the clinical symptoms(abdominal pain，bloating)，and ICU hospitalization time.Results After treatment，the clinical indexes of Apache II score，C-reactive protein，procalcitonin and blood TNF-a concentration in the observation group were superior to the control group，and the difference was statistically significant(P<0.05).The recovery time of abdominal pain and bloating in the observation group were(18.50±6.50)h and(17.20±5.20)h，which was shorter than that of the control group(85.05±5.60)h and(82.50±6.50)h，the difference was statistically significant(P<0.05).The ICU stay in the observation group was (7.55±3.50)d，which was shorter than that of the control group (16.50±4.50)d，and the difference was statistically significant(P<0.05).Conclusion On the basis of conventional medical treatment， combined with CRRT for SAP，it can improve the symptoms of patients and shorten the hospitalization time of patients，and the application effect is remarkable.
, 百拇医药
Key words：Medical treatment；Bedside continuous renal replacement；Acute severe pancreatitis；ICU hospitalization time
急性重癥胰腺炎(severe acute pancreatitis，SAP)以胰腺坏死表现为主，严重损害患者胰腺功能，短时间诱发患者死亡[1]。SAP患者有腹痛、腹胀以及恶心、呕吐等症状表现，构成生命安全威胁[2]。内科常规治疗SAP效果一般，床旁连续性肾脏替代疗法(CRRT)在SAP治疗方面整体效果显著，短时间改善患者症状表现[3]。基于此，本文就我院72例SAP患者作为实验对象，进行分组治疗对比研究，总结联合治疗方案价值。, http://www.100md.com(侯昌权 乔云静)
, http://www.100md.com
关键词：内科治疗；床旁连续性肾脏替代；急性重症胰腺炎；ICU住院时间
中图分类号：R576 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.13.031
文章编号：1006-1959(2018)13-0107-03
Abstract：Objective To summarize the effect of routine medical therapy combined with continuous bedside renal replacement therapy in the treatment of severe acute pancreatitis and to provide reference for the treatment of severe acute pancreatitis.Methods 72 patients with SAP from August 2015 to December 2016 in our hospital were randomly divided into control group and observation group with 36 cases in each group.The control group was treated with routine internal medicine，the observation group was treated with CRRT.The changes of experimental indexes such as Apache II score，C-reactive protein，procalcitonin and blood TNF-a concentration in the two groups of SAP patients were compared with the clinical symptoms(abdominal pain，bloating)，and ICU hospitalization time.Results After treatment，the clinical indexes of Apache II score，C-reactive protein，procalcitonin and blood TNF-a concentration in the observation group were superior to the control group，and the difference was statistically significant(P<0.05).The recovery time of abdominal pain and bloating in the observation group were(18.50±6.50)h and(17.20±5.20)h，which was shorter than that of the control group(85.05±5.60)h and(82.50±6.50)h，the difference was statistically significant(P<0.05).The ICU stay in the observation group was (7.55±3.50)d，which was shorter than that of the control group (16.50±4.50)d，and the difference was statistically significant(P<0.05).Conclusion On the basis of conventional medical treatment， combined with CRRT for SAP，it can improve the symptoms of patients and shorten the hospitalization time of patients，and the application effect is remarkable.
, 百拇医药
Key words：Medical treatment；Bedside continuous renal replacement；Acute severe pancreatitis；ICU hospitalization time
急性重癥胰腺炎(severe acute pancreatitis，SAP)以胰腺坏死表现为主，严重损害患者胰腺功能，短时间诱发患者死亡[1]。SAP患者有腹痛、腹胀以及恶心、呕吐等症状表现，构成生命安全威胁[2]。内科常规治疗SAP效果一般，床旁连续性肾脏替代疗法(CRRT)在SAP治疗方面整体效果显著，短时间改善患者症状表现[3]。基于此，本文就我院72例SAP患者作为实验对象，进行分组治疗对比研究，总结联合治疗方案价值。, http://www.100md.com(侯昌权 乔云静)