大黄蛰虫方合逍遥方加减对原发性肝细胞癌TACE术后综合征影响(1)
摘 要：目的 探讨大黄蛰虫方合逍遥方加减对原发性肝细胞癌TACE术后综合征影响及临床意义。方法 选取2016年10月～2017年8月来我院肿瘤科30例及邯郸中心医院介入科30例就诊的Ⅱ～Ⅲ期不能手术的原发性肝细胞癌患者，随机分为治疗组和对照组，每组30例。对照组采取单纯经皮肝動脉化疗栓塞术治疗，治疗组在对照组基础上联合大黄蛰虫方合逍遥方加减治疗。观察两组患者治疗后不良反应发生率以及肝功能变化情况。结果 治疗组恶心、呕吐、发热、腹痛发生率分别为16.67%、13.33%、26.67%、20.00%，对照组恶心、呕吐、发热、腹痛发生率分别为33.33%、30.00%、40.00%、36.67%，治疗组术后综合征发生比例少于对照组，差异有统计学意义(P<0.05)。观察术后3 d、7 d、14 d肝功能中谷丙转氨酶ALT值治疗组指标低于对照组，差异有统计学意义(P<0.05)。结论 大黄蛰虫方合逍遥方加减联合经皮肝动脉化疗栓塞术，疗效显著，可以明显降低原发性肝细胞癌TACE术后综合征发生率。
关键词：大黄蛰虫方；逍遥方；原发性肝癌；TACE
, 百拇医药
中图分类号：R735.7 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.017
文章编号：1006-1959(2018)14-0053-04
Abstract：Objective To investigate the effect and clinical significance ofRhubarb Aphid combined with Xiaoyaofang Decoction on postoperative TACE syndrome in primary hepatocellular carcinoma.Methods From October 2016 to August 2017，30 patients with oncology in our hospital and 30 patients with interventional department in the Central Hospital were treated with stage II～III inoperable primary hepatocellular carcinoma.They were randomly divided into treatment group and control group，30 cases in each group.The control group was treated with simple percutaneous transhepatic arterial chemoembolization.The treatment group was treated with the combination of Rhubarb Aphid Fanghe Xiaoyaofang Decoction.The incidence of adverse reactions and changes in liver function after treatment were observed.Results The incidences of nausea，vomiting，fever and abdominal pain in the treatment group were 16.67%，13.33%，26.67%，and 20.00%，respectively.The incidences of nausea，vomiting，fever，and abdominal pain in the control group were 33.33%，30.00%，40.00%，and 36.67%，respectively.The incidence of postoperative syndrome in the treatment group was lower than that in the control group，and the difference was statistically significant (P<0.05).The indexes of alanine aminotransferase ALT in the liver function were lower than those in the control group at 3，7 and 14d after operation，the difference was statistically significant(P<0.05).Conclusion Rhubarb Aphid combined with Fanghe Xiaoyaofang Decoction combined with percutaneous transhepatic arterial chemoembolization has significant curative effect and can significantly reduce the incidence of postoperative TACE syndrome in primary hepatocellular carcinoma.
, 百拇医药
Key words：Rhubarb Aphid；Fanghe Xiaoyaofang；Primary hepatocellular carcinoma；TACE
原发性肝细胞癌(primary hepatocellular carcinoma)是全球临床发病率较高的消化系恶性肿瘤之一，每年约有85万余新发病例，81万人死亡。我国由于乙肝病毒感染、饮水污染、酗酒等原因，为肝癌高发区，每年新发病例46万余例，42万人死亡。原发性肝癌中90%以上为肝细胞癌。近年来经皮肝动脉化疗栓塞术(TACE)是目前临床公认的治疗不能实施手术的原发性肝细胞癌患者的有效手段。大量国内外文献报道均对TACE治疗中晚期肝癌患者的近期抗肿瘤疗效、灭杀肿瘤细胞效果以及延长生存期等方面的优势进行过报道[1，2]。在我国TACE已经在临床上开展多年，效果也得到验证，已经逐渐成为了中晚期原发性肝细胞癌的一线治疗方案[3]。TACE治疗仍有一定的局限性，注入大量化疗药物对患者肝功能可能有损伤，肝脏有双重血供，TACE术中仅栓塞肝动脉仍难以彻底阻断肿瘤血供，TACE术难以覆盖全部肿瘤组织[4-6]。中草药在调节机体免疫、内分泌和神经功能等方面均有独特的效果，辅助抑制肿瘤和减轻化疗药物的毒性[7]。本研究应用大黄蛰虫方合逍遥方加减，有“行气化瘀、健脾消积”之功效，够协助化疗药物对肿瘤细胞的攻击，提高化疗效果，减少TACE术后综合征，现研究报道如下。, http://www.100md.com(侯宝松 王海峰 徐海晶 檀增宪 詹文彦 宋玉勤 张艳敏 刘霞)
关键词：大黄蛰虫方；逍遥方；原发性肝癌；TACE
, 百拇医药
中图分类号：R735.7 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.14.017
文章编号：1006-1959(2018)14-0053-04
Abstract：Objective To investigate the effect and clinical significance ofRhubarb Aphid combined with Xiaoyaofang Decoction on postoperative TACE syndrome in primary hepatocellular carcinoma.Methods From October 2016 to August 2017，30 patients with oncology in our hospital and 30 patients with interventional department in the Central Hospital were treated with stage II～III inoperable primary hepatocellular carcinoma.They were randomly divided into treatment group and control group，30 cases in each group.The control group was treated with simple percutaneous transhepatic arterial chemoembolization.The treatment group was treated with the combination of Rhubarb Aphid Fanghe Xiaoyaofang Decoction.The incidence of adverse reactions and changes in liver function after treatment were observed.Results The incidences of nausea，vomiting，fever and abdominal pain in the treatment group were 16.67%，13.33%，26.67%，and 20.00%，respectively.The incidences of nausea，vomiting，fever，and abdominal pain in the control group were 33.33%，30.00%，40.00%，and 36.67%，respectively.The incidence of postoperative syndrome in the treatment group was lower than that in the control group，and the difference was statistically significant (P<0.05).The indexes of alanine aminotransferase ALT in the liver function were lower than those in the control group at 3，7 and 14d after operation，the difference was statistically significant(P<0.05).Conclusion Rhubarb Aphid combined with Fanghe Xiaoyaofang Decoction combined with percutaneous transhepatic arterial chemoembolization has significant curative effect and can significantly reduce the incidence of postoperative TACE syndrome in primary hepatocellular carcinoma.
, 百拇医药
Key words：Rhubarb Aphid；Fanghe Xiaoyaofang；Primary hepatocellular carcinoma；TACE
原发性肝细胞癌(primary hepatocellular carcinoma)是全球临床发病率较高的消化系恶性肿瘤之一，每年约有85万余新发病例，81万人死亡。我国由于乙肝病毒感染、饮水污染、酗酒等原因，为肝癌高发区，每年新发病例46万余例，42万人死亡。原发性肝癌中90%以上为肝细胞癌。近年来经皮肝动脉化疗栓塞术(TACE)是目前临床公认的治疗不能实施手术的原发性肝细胞癌患者的有效手段。大量国内外文献报道均对TACE治疗中晚期肝癌患者的近期抗肿瘤疗效、灭杀肿瘤细胞效果以及延长生存期等方面的优势进行过报道[1，2]。在我国TACE已经在临床上开展多年，效果也得到验证，已经逐渐成为了中晚期原发性肝细胞癌的一线治疗方案[3]。TACE治疗仍有一定的局限性，注入大量化疗药物对患者肝功能可能有损伤，肝脏有双重血供，TACE术中仅栓塞肝动脉仍难以彻底阻断肿瘤血供，TACE术难以覆盖全部肿瘤组织[4-6]。中草药在调节机体免疫、内分泌和神经功能等方面均有独特的效果，辅助抑制肿瘤和减轻化疗药物的毒性[7]。本研究应用大黄蛰虫方合逍遥方加减，有“行气化瘀、健脾消积”之功效，够协助化疗药物对肿瘤细胞的攻击，提高化疗效果，减少TACE术后综合征，现研究报道如下。, http://www.100md.com(侯宝松 王海峰 徐海晶 檀增宪 詹文彦 宋玉勤 张艳敏 刘霞)