注射用鼠神经生长因子联合利培酮治疗儿童孤独症的临床疗效分析(1)
摘 要：目的 探讨注射用鼠神经生长因子联合利培酮治疗儿童孤独症的临床疗效。方法 选取我院小儿神经专科收治的65例儿童孤独症患儿，随机分为两组，对照组31例患儿单用利培酮治疗，治疗组34例患儿予注射用鼠神经生长因子联合利培酮治疗。所有患儿均在治疗前和治疗后3个月进行ABC量表、CARS量表评定，对比两组患儿量表评分情况及临床有效率。结果 治疗后，治疗组ABC量表中感觉能力、交往能力、运动能力、语言能力及自我照顾5项评分均优于对照组(P<0.05)；对照组和治疗组CARS量表总分均比治疗前降低(P<0.05)，治疗组与对照组相比，CARS量表总分降低更明显(P<0.05)。治疗组临床有效率为94.11%，高于对照组的77.42%，差异具有统计学意义(P<0.05)。结论 注射用鼠神经生长因子联合利培酮较利培酮单药治疗儿童孤独症疗效更佳，不良反应少。
关键词：注射用鼠神经生长因子；利培酮；儿童孤独症
中图分类号：R749.94 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.019
, 百拇医药
文章编号：1006-1959(2018)17-0063-03
Abstract：Objective To investigate the clinical efficacy of injection of mouse nerve growth factor combined with risperidone in the treatment of childhood autism.Methods A total of 65 children with autism admitted to our hospital were randomly divided into two groups.31 patients in the control group were treated with risperidone alone，34 patients in the treatment group were treated with injection of mouse nerve growth factor combined with risperidone.All children were assessed on the ABC scale and CARS scale before treatment and 3 months after treatment，and the scores and clinical effectiveness of the two groups were compared.Results After treatment，the scores of sensory ability，communication ability，exercise ability，language ability and self-care in the ABC scale of the treatment group were better than those of the control group(P<0.05)，the total scores of CARS scales in the control group and the treatment group were lower than those before treatment(P<0.05).Compared with the control group，the total score of the CARS scale was significantly lower in the treatment group(P<0.05).The clinical effective rate was 94.11% in the treatment group，which was higher than 77.42% in the control group，the difference was statistically significant(P<0.05).Conclusion The injection of mouse nerve growth factor combined with risperidone is better than risperidone in the treatment of childhood autism with less adverse reactions.
, http://www.100md.com
Key words：Mouse nerve growth factor for injection；Risperidone；Childhood autism
儿童孤独症谱系障碍(autism spectrum disorder，ASD)又称自闭症，是一组以语言发育落后、社交障碍、兴趣或活动范围狭窄及刻板动作为特征的神经发育障碍性疾病[1]。孤独症患儿除了以上核心症状外，很多还合并精神运动发育迟缓，伴有多动、冲动、攻击他人等异常行为，预后较差，给家庭和社会造成巨大的负担。目前尚无特效药物治疗孤独症，针对患儿伴随的异常精神行为可以采用一些抗精神病药物、抗抑郁药物治疗等。有报道，利培酮应用于儿童孤独症的治疗有一定临床效果，可以改善患儿的攻击、自伤、多动等异常行为，而脑神经营养药物例如鼠神經生长因子对孤独症患儿有一定的治疗作用[2，3]。本研究探讨注射用鼠神经生长因子联合利培酮治疗儿童孤独症的临床疗效，现报道如下。
1资料与方法
1.1一般资料 选取2015年5月～2017年11月中山大学孙逸仙纪念医院小儿神经专科住院部收治的65例孤独症患儿，本研究经医院伦理会批准。采用随机数字表法将患儿分为对照组和治疗组。对照组31例，男17例，女14例，年龄2～7岁，平均年龄(4.12±1.98)岁；治疗组34例，男18例，女16例，年龄2～7岁，平均年龄(3.96±2.26)岁。两组患者性别、年龄等一般资料相比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(周小琳 陈雪贞 李栋方 何展文 罗向阳)
关键词：注射用鼠神经生长因子；利培酮；儿童孤独症
中图分类号：R749.94 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.019
, 百拇医药
文章编号：1006-1959(2018)17-0063-03
Abstract：Objective To investigate the clinical efficacy of injection of mouse nerve growth factor combined with risperidone in the treatment of childhood autism.Methods A total of 65 children with autism admitted to our hospital were randomly divided into two groups.31 patients in the control group were treated with risperidone alone，34 patients in the treatment group were treated with injection of mouse nerve growth factor combined with risperidone.All children were assessed on the ABC scale and CARS scale before treatment and 3 months after treatment，and the scores and clinical effectiveness of the two groups were compared.Results After treatment，the scores of sensory ability，communication ability，exercise ability，language ability and self-care in the ABC scale of the treatment group were better than those of the control group(P<0.05)，the total scores of CARS scales in the control group and the treatment group were lower than those before treatment(P<0.05).Compared with the control group，the total score of the CARS scale was significantly lower in the treatment group(P<0.05).The clinical effective rate was 94.11% in the treatment group，which was higher than 77.42% in the control group，the difference was statistically significant(P<0.05).Conclusion The injection of mouse nerve growth factor combined with risperidone is better than risperidone in the treatment of childhood autism with less adverse reactions.
, http://www.100md.com
Key words：Mouse nerve growth factor for injection；Risperidone；Childhood autism
儿童孤独症谱系障碍(autism spectrum disorder，ASD)又称自闭症，是一组以语言发育落后、社交障碍、兴趣或活动范围狭窄及刻板动作为特征的神经发育障碍性疾病[1]。孤独症患儿除了以上核心症状外，很多还合并精神运动发育迟缓，伴有多动、冲动、攻击他人等异常行为，预后较差，给家庭和社会造成巨大的负担。目前尚无特效药物治疗孤独症，针对患儿伴随的异常精神行为可以采用一些抗精神病药物、抗抑郁药物治疗等。有报道，利培酮应用于儿童孤独症的治疗有一定临床效果，可以改善患儿的攻击、自伤、多动等异常行为，而脑神经营养药物例如鼠神經生长因子对孤独症患儿有一定的治疗作用[2，3]。本研究探讨注射用鼠神经生长因子联合利培酮治疗儿童孤独症的临床疗效，现报道如下。
1资料与方法
1.1一般资料 选取2015年5月～2017年11月中山大学孙逸仙纪念医院小儿神经专科住院部收治的65例孤独症患儿，本研究经医院伦理会批准。采用随机数字表法将患儿分为对照组和治疗组。对照组31例，男17例，女14例，年龄2～7岁，平均年龄(4.12±1.98)岁；治疗组34例，男18例，女16例，年龄2～7岁，平均年龄(3.96±2.26)岁。两组患者性别、年龄等一般资料相比，差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(周小琳 陈雪贞 李栋方 何展文 罗向阳)