血清胱抑素C及同型半胱氨酸与2型糖尿病视网膜病变的相关性分析(1)
摘 要：目的 探讨CysC与Hcy与2型糖尿病视网膜病变的相关性。方法 选取我院2017年1月～12月收治的2型糖尿病患者160例，根据眼底照相结果分为糖尿病视网膜病变组(DR组)和糖尿病无视网膜病变组(NDR组)，每组80例，同时选取健康受试者80例作为对照组。观察各组患者血糖、血脂、血清CysC及Hcy水平。结果 ①DR组和NDR组SBP、DBP、FBG、2hBG、TG、TC、LDL-C、BUN、SCr、HbA1C、CysC和Hcy水平均高于对照组，差异具有统计学意义(P<0.05)；DR组和NDR组HDL-C水平低于对照组，差异具有统计学意义(P<0.05)；DR组SBP、TG、SCr、CysC和Hcy水平高于NDR组，差异具有统计学意义(P<0.05)。②CysC与病程、TG、SCr、Hcy呈正相关(r=0.428、0.490、0.479、0.215，P<0.05)，与BMI、SBP、LDL-C、FBG无明显相关性。③Logistic多元回归分析显示：TG、SBP、CysC和Hcy为影响2型糖尿病视网膜病变发生的危险因素。结论 高CysC及Hcy水平是发生糖尿病视网膜病变的危险因素，CysC联合Hcy检测对2型糖尿病视网病变的诊治有一定指导意义。
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关键词：糖尿病视网膜病变；血清胱抑素C；同型半胱氨酸；相关性
中图分类号：R587.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.027
文章编号：1006-1959(2018)17-0089-03
Abstract：Objective To investigate the relationship between CysC and Hcy and type 2 diabetic retinopathy.Methods A total of 160 patients with type 2 diabetes admitted to our hospital from January to December 2017 were enrolled.According to the results of fundus photography，the patients were divided into diabetic retinopathy group(DR group)and diabetic non-retinopathy group(NDR group)，80 cases in each group，and 80 healthy subjects were selected as the control group.Blood glucose，blood lipids，serum CysC and Hcy levels were observed in each group.Results ①The levels of SBP，DBP，FBG，2hBG，TG，TC，LDL-C，BUN，SCr，HbA1C，CysC and Hcy in DR group and NDR group were higher than those in the control group，the difference was statistically significant(P<0.05)；The HDL-C levels in the DR group and the NDR group were lower than those in the control group，the difference was statistically significant(P<0.05)；the levels of SBP，TG，SCr，CysC and Hcy in the DR group were higher than those in the NDR group，the difference was statistically significant(P<0.05).②CysC was positively correlated with disease course，TG，SCr and Hcy(r=0.428，0.490，0.479，0.215，P<0.05)，and had no significant correlation with BMI，SBP，LDL-C and FBG.③Logistic multiple regression analysis showed that TG，SBP，CysC and Hcy were risk factors for the development of type 2 diabetic retinopathy.Conclusion High CysC and Hcy levels are risk factors for diabetic retinopathy.CysC combined with Hcy detection has certain guiding significance for the diagnosis and treatment of type 2 diabetic retinopathy.
, 百拇医药
Key words：Diabetic retinopathy；Serum cystatin C；Homocysteine；Correlation
微血管病变(microangiopathy)是2型糖尿病患者最为常见且严重的慢性并发症之一[1-3]，临床上常以糖尿病视网膜病变(diabetic retinopathy，DR)、糖尿病肾病(diabetic nephropathy，DN)等为主要表现。研究发现，严重的糖尿病视网膜病变可导致失明[4]。研究表明，血清胱抑素C(CysC)是理想的反映肾小球滤过功能的内源性指标，在早期肾损伤诊断中敏感性较高[5]，血清CysC可作为预测2型糖尿病早期肾病的指标[6]。近年来研究證实，同型半胱氨酸(Hcy)是导致动脉粥样硬化的独立危险因素，其与糖尿病心脑血管并发症的发生密切相关[7]。但两者与糖尿病视网膜病变的相关性研究相对较少，本研究通过检测糖尿病视网膜病变患者中血清CysC及Hcy水平，了解其与糖尿病视网膜病变的相关性，探讨血清CysC及Hcy预测糖尿病视网膜病变的价值，为临床防治糖尿病视网膜病变提供理论依据。, http://www.100md.com(闫宇梅)
, http://www.100md.com
关键词：糖尿病视网膜病变；血清胱抑素C；同型半胱氨酸；相关性
中图分类号：R587.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.17.027
文章编号：1006-1959(2018)17-0089-03
Abstract：Objective To investigate the relationship between CysC and Hcy and type 2 diabetic retinopathy.Methods A total of 160 patients with type 2 diabetes admitted to our hospital from January to December 2017 were enrolled.According to the results of fundus photography，the patients were divided into diabetic retinopathy group(DR group)and diabetic non-retinopathy group(NDR group)，80 cases in each group，and 80 healthy subjects were selected as the control group.Blood glucose，blood lipids，serum CysC and Hcy levels were observed in each group.Results ①The levels of SBP，DBP，FBG，2hBG，TG，TC，LDL-C，BUN，SCr，HbA1C，CysC and Hcy in DR group and NDR group were higher than those in the control group，the difference was statistically significant(P<0.05)；The HDL-C levels in the DR group and the NDR group were lower than those in the control group，the difference was statistically significant(P<0.05)；the levels of SBP，TG，SCr，CysC and Hcy in the DR group were higher than those in the NDR group，the difference was statistically significant(P<0.05).②CysC was positively correlated with disease course，TG，SCr and Hcy(r=0.428，0.490，0.479，0.215，P<0.05)，and had no significant correlation with BMI，SBP，LDL-C and FBG.③Logistic multiple regression analysis showed that TG，SBP，CysC and Hcy were risk factors for the development of type 2 diabetic retinopathy.Conclusion High CysC and Hcy levels are risk factors for diabetic retinopathy.CysC combined with Hcy detection has certain guiding significance for the diagnosis and treatment of type 2 diabetic retinopathy.
, 百拇医药
Key words：Diabetic retinopathy；Serum cystatin C；Homocysteine；Correlation
微血管病变(microangiopathy)是2型糖尿病患者最为常见且严重的慢性并发症之一[1-3]，临床上常以糖尿病视网膜病变(diabetic retinopathy，DR)、糖尿病肾病(diabetic nephropathy，DN)等为主要表现。研究发现，严重的糖尿病视网膜病变可导致失明[4]。研究表明，血清胱抑素C(CysC)是理想的反映肾小球滤过功能的内源性指标，在早期肾损伤诊断中敏感性较高[5]，血清CysC可作为预测2型糖尿病早期肾病的指标[6]。近年来研究證实，同型半胱氨酸(Hcy)是导致动脉粥样硬化的独立危险因素，其与糖尿病心脑血管并发症的发生密切相关[7]。但两者与糖尿病视网膜病变的相关性研究相对较少，本研究通过检测糖尿病视网膜病变患者中血清CysC及Hcy水平，了解其与糖尿病视网膜病变的相关性，探讨血清CysC及Hcy预测糖尿病视网膜病变的价值，为临床防治糖尿病视网膜病变提供理论依据。, http://www.100md.com(闫宇梅)