经尿道电切术联合吉西他滨灌注治疗膀胱癌的临床效果分析(1)
摘 要：目的 探讨经尿道电切术联合吉西他滨灌注治疗膀胱癌的临床效果。方法 选取2013年2月～2017年3月我院收治的膀胱癌患者90例，根据患者治疗意愿分为A组和B组，每组45例。A组进行经尿道电切术联合吡柔比星灌注，B组进行经尿道电切术联合吉西他滨灌注。比较两组膀胱癌疗效、住院时间、手术前后患者生存质量评分、卡氏评分以及放射性尿道炎、腹泻、白细胞减少等并发症发生率。结果 B组治疗总有效率为75.55%，高于A组的44.44%，差异具有统计学意义(P<0.05)。手术后，B组生存质量评分和卡氏评分均优于A组，差异具有统计学意义(P<0.05)。B组住院时间为(10.02±0.12)d，优于A组的(12.14±0.24)d，差異具有统计学意义(P<0.05)。B组放射性尿道炎、腹泻、白细胞减少的发生率低于A组，差异具有统计学意义(P<0.05)。结论 行经尿道电切术联合吉西他滨灌注治疗膀胱癌疗效理想，可有效缩短住院时间，减少并发症，提高患者生存质量提高、提升健康水平。
关键词：经尿道电切术；吉西他滨灌注；膀胱癌
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中图分类号：R737.14 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.026
文章编号：1006-1959(2018)20-0091-03
Abstract：Objective To investigate the clinical effect of transurethral resection combined with gemcitabine perfusion in the treatment of bladder cancer.Methods 90 patients with bladder cancer admitted to our hospital from February 2013 to March 2017 were enrolled. According to the patient's willingness to treat，they were divided into group A and group B，with 45 cases in each group.Group A underwent transurethral resection with pirarubicin perfusion，and group B underwent transurethral resection with gemcitabine perfusion.The efficacy of the two groups of bladder cancer，length of hospital stay，quality of life score before and after surgery，Karsten score，and incidence of complications such as radiation urethritis，diarrhea，and leukopenia were compared.Results The total effective rate of group B was 75.55%，which was higher than that of group A 44.44%，the difference was statistically significant(P<0.05).After operation，the quality of life score and the Karsten score of group B were better than those of group A，the difference was statistically significant (P<0.05).The hospital stay in group B was(10.02±0.12) d，which was better than that in group A(12.14±0.24)d，the difference was statistically significant(P<0.05).The incidence of radiation urethritis，diarrhea and leukopenia in group B was lower than that in group A，the difference was statistically significant(P<0.05).Conclusion Transurethral resection combined with gemcitabine perfusion for bladder cancer is effective，which can shorten the hospital stay，reduce complications，improve the quality of life and improve the health.
Key words：Transurethral resection；Gemcitabine perfusion；Bladder cancer
膀胱癌(bladder cancer)是指发生在膀胱黏膜上的恶性肿瘤，是泌尿系统最常见的恶性肿瘤，也是全身十大常见肿瘤之一。随着人们生活方式发生改变，膀胱癌发病率也有所提高，非肌层浸润性膀胱癌在膀胱癌的患者中约占75%，具有较高的复发率[1]。且在膀胱癌复发之后，其病情恶化，恶性程度提升。目前对于膀胱癌的治疗一般用手术治疗，但创伤大且无法有效保留膀胱功能[2]。本研究选取我院2013年2月～2017年3月收治的膀胱癌患者90例，分析经尿道电切术联合吉西他滨灌注治疗膀胱癌的临床效果，现报告如下。, 百拇医药(幸世玉)
关键词：经尿道电切术；吉西他滨灌注；膀胱癌
, http://www.100md.com
中图分类号：R737.14 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.026
文章编号：1006-1959(2018)20-0091-03
Abstract：Objective To investigate the clinical effect of transurethral resection combined with gemcitabine perfusion in the treatment of bladder cancer.Methods 90 patients with bladder cancer admitted to our hospital from February 2013 to March 2017 were enrolled. According to the patient's willingness to treat，they were divided into group A and group B，with 45 cases in each group.Group A underwent transurethral resection with pirarubicin perfusion，and group B underwent transurethral resection with gemcitabine perfusion.The efficacy of the two groups of bladder cancer，length of hospital stay，quality of life score before and after surgery，Karsten score，and incidence of complications such as radiation urethritis，diarrhea，and leukopenia were compared.Results The total effective rate of group B was 75.55%，which was higher than that of group A 44.44%，the difference was statistically significant(P<0.05).After operation，the quality of life score and the Karsten score of group B were better than those of group A，the difference was statistically significant (P<0.05).The hospital stay in group B was(10.02±0.12) d，which was better than that in group A(12.14±0.24)d，the difference was statistically significant(P<0.05).The incidence of radiation urethritis，diarrhea and leukopenia in group B was lower than that in group A，the difference was statistically significant(P<0.05).Conclusion Transurethral resection combined with gemcitabine perfusion for bladder cancer is effective，which can shorten the hospital stay，reduce complications，improve the quality of life and improve the health.
Key words：Transurethral resection；Gemcitabine perfusion；Bladder cancer
膀胱癌(bladder cancer)是指发生在膀胱黏膜上的恶性肿瘤，是泌尿系统最常见的恶性肿瘤，也是全身十大常见肿瘤之一。随着人们生活方式发生改变，膀胱癌发病率也有所提高，非肌层浸润性膀胱癌在膀胱癌的患者中约占75%，具有较高的复发率[1]。且在膀胱癌复发之后，其病情恶化，恶性程度提升。目前对于膀胱癌的治疗一般用手术治疗，但创伤大且无法有效保留膀胱功能[2]。本研究选取我院2013年2月～2017年3月收治的膀胱癌患者90例，分析经尿道电切术联合吉西他滨灌注治疗膀胱癌的临床效果，现报告如下。, 百拇医药(幸世玉)