α1胸腺肽联合化疗治疗老年晚期胃癌的效果及对外周血T淋巴细胞亚群的影响(1)
摘 要：目的 探讨α1胸腺肽联合化疗治疗老年晚期胃癌的效果及对外周血T淋巴细胞亚群的影响。方法 将我院2015年7月～2017年6月收治的90例老年晚期胃癌患者随机分为对照组和观察组，每组45例。对照组予以FOLFOX6化疗方案治疗，观察组在对照组基础上增加α1胸腺肽治疗。比较两组患者临床疗效和外周血T淋巴细胞亚群的情况。结果 观察组患者的治疗总有效率为75.56%，高于对照组的51.11%，差异具有统计学意义(P<0.05)。观察组患者的外周血T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+水平高于对照组，差异具有统计学意义(P<0.05)。两组患者CD8+水平比较，差异无统计学意义(P>0.05)。结论 α1胸腺肽联合化疗治疗老年晚期胃癌的效果显著，并可有效调节患者的外周血T淋巴细胞亚群水平。
关键词：老年晚期胃癌；α1胸腺肽；外周血T淋巴细胞亚群
中图分类号：R735.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.028
, http://www.100md.com
文章编号：1006-1959(2018)20-0096-03
Abstract：Objective To investigate the effect of α1 thymosin combined with chemotherapy on elderly patients with advanced gastric cancer and the influence of peripheral blood T lymphocyte subsets.Methods 90 patients with advanced gastric cancer admitted to our hospital from July 2015 to June 2017 were randomly divided into control group and observation group，with 45 cases in each group. The control group was treated with FOLFOX6 chemotherapy，and the observation group was treated with α1 thymosin on the basis of the control group.The clinical efficacy and peripheral blood T lymphocyte subsets were compared between the two groups.Results The total effective rate of the observation group was 75.56%，which was higher than that of the control group 51.11%，the difference was statistically significant(P<0.05).The levels of CD3+，CD4+，CD4+/CD8+ in the peripheral blood T lymphocyte subsets of the observation group were higher than those of the control group，the difference was statistically significant(P<0.05).There was no significant difference in CD8+ levels between the two groups(P>0.05).Conclusion α1 thymosin combined with chemotherapy is effective in the treatment of advanced gastric cancer in the elderly，and can effectively regulate the peripheral blood T lymphocyte subsets.
, http://www.100md.com
Key words：Advanced gastric cancer in the elderly；α1 thymosin；Peripheral blood T lymphocyte subsets
胃癌(gastric cancer)本身就屬于恶性肿瘤之一，加上老年人体质衰退，免疫功能减弱，因此老年晚期胃癌患者的死亡率极高。有关统计显示[1]，每年胃癌死亡人数高达16万，约占恶性肿瘤死亡人数的25%。化疗是治疗恶性肿瘤疾病的常用方法，可在一定程度上延长患者生存时间。α1胸腺肽具有提高人体免疫能力、抑制肿瘤细胞活化的作用，本研究探讨了α1胸腺肽联合化疗治疗老年晚期胃癌的效果及对外周血T淋巴细胞亚群的影响，具体内容报告如下。
1资料与方法
1.1 一般资料 选取2015年7月～2017年6月辽宁省绥中县医院收治的90例老年晚期胃癌患者为研究对象，所有研究对象均符合晚期胃癌诊断标准[2]。采用随机数字表法将患者分为对照组和观察组，每组45例。对照组男性27例，女性18例，年龄60～79岁，平均年龄(72.93±7.75)岁；病程1～4年，平均病程(2.62±0.41)年；TNM分期：Ⅲ期14例，Ⅳ期31例。观察组男性26例，女性19例，年龄60～78岁，平均年龄(71.16±7.72)岁；病程1～5年，平均病程(2.59±0.50)年；TNM分期：Ⅲ期15例，Ⅳ期30例。两组患者性别、年龄、病程、TNM分期等基线资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
1.2.1对照组 给予患者FOLFOX6化疗方案治疗。化疗当天静脉滴注奥沙利铂(费森尤斯卡比医药有限公司，国药准字H20093892，规格：50 mg)85 mg/m2，2 h内滴注完成；静脉滴注亚叶酸钙(哈尔滨三联药业股份有限公司，国药准字H20034073，规格：100 mg)400 mg/m2，2 h内滴注完成；然后持续静脉滴注5-氟尿嘧啶(南通精华制药股份有限公司，国药准字H32022246，规格：0.25 g)2400 mg/m2，连续滴注46 h内完成。14 d为1个疗程，连续治疗3个疗程。, http://www.100md.com(张静)
关键词：老年晚期胃癌；α1胸腺肽；外周血T淋巴细胞亚群
中图分类号：R735.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.028
, http://www.100md.com
文章编号：1006-1959(2018)20-0096-03
Abstract：Objective To investigate the effect of α1 thymosin combined with chemotherapy on elderly patients with advanced gastric cancer and the influence of peripheral blood T lymphocyte subsets.Methods 90 patients with advanced gastric cancer admitted to our hospital from July 2015 to June 2017 were randomly divided into control group and observation group，with 45 cases in each group. The control group was treated with FOLFOX6 chemotherapy，and the observation group was treated with α1 thymosin on the basis of the control group.The clinical efficacy and peripheral blood T lymphocyte subsets were compared between the two groups.Results The total effective rate of the observation group was 75.56%，which was higher than that of the control group 51.11%，the difference was statistically significant(P<0.05).The levels of CD3+，CD4+，CD4+/CD8+ in the peripheral blood T lymphocyte subsets of the observation group were higher than those of the control group，the difference was statistically significant(P<0.05).There was no significant difference in CD8+ levels between the two groups(P>0.05).Conclusion α1 thymosin combined with chemotherapy is effective in the treatment of advanced gastric cancer in the elderly，and can effectively regulate the peripheral blood T lymphocyte subsets.
, http://www.100md.com
Key words：Advanced gastric cancer in the elderly；α1 thymosin；Peripheral blood T lymphocyte subsets
胃癌(gastric cancer)本身就屬于恶性肿瘤之一，加上老年人体质衰退，免疫功能减弱，因此老年晚期胃癌患者的死亡率极高。有关统计显示[1]，每年胃癌死亡人数高达16万，约占恶性肿瘤死亡人数的25%。化疗是治疗恶性肿瘤疾病的常用方法，可在一定程度上延长患者生存时间。α1胸腺肽具有提高人体免疫能力、抑制肿瘤细胞活化的作用，本研究探讨了α1胸腺肽联合化疗治疗老年晚期胃癌的效果及对外周血T淋巴细胞亚群的影响，具体内容报告如下。
1资料与方法
1.1 一般资料 选取2015年7月～2017年6月辽宁省绥中县医院收治的90例老年晚期胃癌患者为研究对象，所有研究对象均符合晚期胃癌诊断标准[2]。采用随机数字表法将患者分为对照组和观察组，每组45例。对照组男性27例，女性18例，年龄60～79岁，平均年龄(72.93±7.75)岁；病程1～4年，平均病程(2.62±0.41)年；TNM分期：Ⅲ期14例，Ⅳ期31例。观察组男性26例，女性19例，年龄60～78岁，平均年龄(71.16±7.72)岁；病程1～5年，平均病程(2.59±0.50)年；TNM分期：Ⅲ期15例，Ⅳ期30例。两组患者性别、年龄、病程、TNM分期等基线资料比较，差异无统计学意义(P>0.05)，具有可比性。
1.2方法
1.2.1对照组 给予患者FOLFOX6化疗方案治疗。化疗当天静脉滴注奥沙利铂(费森尤斯卡比医药有限公司，国药准字H20093892，规格：50 mg)85 mg/m2，2 h内滴注完成；静脉滴注亚叶酸钙(哈尔滨三联药业股份有限公司，国药准字H20034073，规格：100 mg)400 mg/m2，2 h内滴注完成；然后持续静脉滴注5-氟尿嘧啶(南通精华制药股份有限公司，国药准字H32022246，规格：0.25 g)2400 mg/m2，连续滴注46 h内完成。14 d为1个疗程，连续治疗3个疗程。, http://www.100md.com(张静)