痰热浓煎剂治疗小儿支原体肺炎的临床疗效研究(1)
摘 要：目的 探讨痰热浓煎剂治疗小儿支原体肺炎(痰热闭肺证)的临床疗效。方法 选取2014年3月～2015年12月我院收治的224例小儿支原体肺炎(痰热闭肺证)患儿作为临床研究对象，采用随机数表法将患者分成研究组和对照组，每组112例。对照组患儿进行阿奇霉素治疗，研究组患儿在对照组的基础上给予痰热浓煎剂进行治疗。观察和比较两组患儿的治疗效果及症状消失情况；统计两组患儿发生不良反应的人数，计算不良反应发生率。结果 研究组治疗后总有效率为95.54%，高于对照组87.50%，差异有统计学意义(P<0.05)；研究组患者发热、咳嗽、肺部体征消失时间及胸部X片恢复正常时间均短于对照组，统计学意义显著(P<0.01)；两组均无不良反应的发生。结论 痰热浓煎剂对治疗小儿支原体肺炎(痰热闭肺证)有良好的治疗效果，无明显不良反应，安全性高。
关键词：痰热浓煎剂；小儿肺炎；痰熱闭肺证；中西医结合治疗
中图分类号：R272 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.044
, http://www.100md.com
文章编号：1006-1959(2018)20-0145-03
Abstract：Objective To investigate the clinical effect of phlegm-heat concentrated decoction on mycoplasma pneumonia in children. Methods 224 children with mycoplasma pneumonia(phlegm heat blocking lung syndrome)from March 2014 to December 2015 were selected as clinical study objects.The patients were randomly divided into study group and control group with 112 cases in each group.Children in control group were treated with azithromycin，and children in study group were treated with concentrated decoction of phlegm heat on the basis of control group.Observe and compare the therapeutic effect and symptom disappearance of the two groups，count the number of adverse reactions in the two groups，calculate the incidence of adverse reactions.Results The total effective rate of the study group95.54%was higher than that of the control group87.50%，the difference was statistically significant(P <0.05)，the time of fever， cough， disappearance of pulmonary signs and the time of chest X ray returning to normal in the study group were shorter than those in the control group，statistical significance was significant(P<0.01)；no adverse reactions occurred in either group.Conclusion The treatment of phlegm-heat concentrated decoction on mycoplasma pneumoniae in children(phlegm-heat blocking lung syndrome)has a good effect，no obvious adverse reactions，high safety.
, 百拇医药
Key words：Concentrated decoction of phlegm and heat；Pneumonia in children；Phlegm heat blocking lung syndrome；Integrated Chinese and western medicine treatment
支原体肺炎(mycoplasma pneumonia，MP)是儿科临床上一种常见的肺部疾病，临床主要表症为发热、咳嗽、气促、痰壅及鼻煽等，肺部X线常表现为单侧或双侧大叶肺部实变。常规抗感染西药治疗中主要采用大环内酯类抗生素治疗，但抗生素耐药性日益严重[1，2]，导致单纯西药治疗效果下降。痰热闭肺证是支原体肺炎的常见证型[3]，其中医发病机制是邪气闭郁于肺，肺失清宣肃降，水液输化无权，则凝而为痰，痰滞肺络，阻于气道，以致肺气上逆，为咳为喘，喉中痰鸣。现代药理学研究表明，痰阻是痰热闭肺症的病理原因。本研究选取224例痰热闭肺症患儿，采取口服痰热浓煎剂并配合西医常规药物治疗的临床疗效差别，现报告如下。
, 百拇医药
1资料与方法
1.1一般资料 选取2014年3月～2015年12月南京市中西医结合医院儿科住院治疗的224例肺炎患儿，本次研究经过医院伦理委员会批准。纳入标准：①符合诸福棠等编写的《实用儿科学》第8版[4]诊断标准临床诊断肺炎。②参照江受传等编写的《中医儿科学》中医支原体肺炎的诊断标准，辨证为痰热闭肺[5]；③患者及监护人均自愿参与本研究，签署知情同意书。排除标准：①中医辨证非痰热闭肺证型；②支原体肺炎变证出现或伴有心力衰竭、呼吸衰竭及中毒性脑病等重症肺炎表现者；③排除患肺炎外其他疾病儿童；④患者及家长不能接受口服中药者。根据随机数字表法分为研究组和对照组，每组112例。研究组男61例，女51例，年龄3～9岁，平均年龄(6.25±1.23)岁，体重16～30 kg，平均体重(25.62±1.23)kg。对照组男65例，女47例，年龄3～8岁，平均年龄(6.34±1.42)岁，体重15～30 kg，平均体重(25.37±1.82)kg。两组性别、年龄和体重比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(夏小兰)
关键词：痰热浓煎剂；小儿肺炎；痰熱闭肺证；中西医结合治疗
中图分类号：R272 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.20.044
, http://www.100md.com
文章编号：1006-1959(2018)20-0145-03
Abstract：Objective To investigate the clinical effect of phlegm-heat concentrated decoction on mycoplasma pneumonia in children. Methods 224 children with mycoplasma pneumonia(phlegm heat blocking lung syndrome)from March 2014 to December 2015 were selected as clinical study objects.The patients were randomly divided into study group and control group with 112 cases in each group.Children in control group were treated with azithromycin，and children in study group were treated with concentrated decoction of phlegm heat on the basis of control group.Observe and compare the therapeutic effect and symptom disappearance of the two groups，count the number of adverse reactions in the two groups，calculate the incidence of adverse reactions.Results The total effective rate of the study group95.54%was higher than that of the control group87.50%，the difference was statistically significant(P <0.05)，the time of fever， cough， disappearance of pulmonary signs and the time of chest X ray returning to normal in the study group were shorter than those in the control group，statistical significance was significant(P<0.01)；no adverse reactions occurred in either group.Conclusion The treatment of phlegm-heat concentrated decoction on mycoplasma pneumoniae in children(phlegm-heat blocking lung syndrome)has a good effect，no obvious adverse reactions，high safety.
, 百拇医药
Key words：Concentrated decoction of phlegm and heat；Pneumonia in children；Phlegm heat blocking lung syndrome；Integrated Chinese and western medicine treatment
支原体肺炎(mycoplasma pneumonia，MP)是儿科临床上一种常见的肺部疾病，临床主要表症为发热、咳嗽、气促、痰壅及鼻煽等，肺部X线常表现为单侧或双侧大叶肺部实变。常规抗感染西药治疗中主要采用大环内酯类抗生素治疗，但抗生素耐药性日益严重[1，2]，导致单纯西药治疗效果下降。痰热闭肺证是支原体肺炎的常见证型[3]，其中医发病机制是邪气闭郁于肺，肺失清宣肃降，水液输化无权，则凝而为痰，痰滞肺络，阻于气道，以致肺气上逆，为咳为喘，喉中痰鸣。现代药理学研究表明，痰阻是痰热闭肺症的病理原因。本研究选取224例痰热闭肺症患儿，采取口服痰热浓煎剂并配合西医常规药物治疗的临床疗效差别，现报告如下。
, 百拇医药
1资料与方法
1.1一般资料 选取2014年3月～2015年12月南京市中西医结合医院儿科住院治疗的224例肺炎患儿，本次研究经过医院伦理委员会批准。纳入标准：①符合诸福棠等编写的《实用儿科学》第8版[4]诊断标准临床诊断肺炎。②参照江受传等编写的《中医儿科学》中医支原体肺炎的诊断标准，辨证为痰热闭肺[5]；③患者及监护人均自愿参与本研究，签署知情同意书。排除标准：①中医辨证非痰热闭肺证型；②支原体肺炎变证出现或伴有心力衰竭、呼吸衰竭及中毒性脑病等重症肺炎表现者；③排除患肺炎外其他疾病儿童；④患者及家长不能接受口服中药者。根据随机数字表法分为研究组和对照组，每组112例。研究组男61例，女51例，年龄3～9岁，平均年龄(6.25±1.23)岁，体重16～30 kg，平均体重(25.62±1.23)kg。对照组男65例，女47例，年龄3～8岁，平均年龄(6.34±1.42)岁，体重15～30 kg，平均体重(25.37±1.82)kg。两组性别、年龄和体重比较，差异无统计学意义(P>0.05)，具有可比性。, 百拇医药(夏小兰)