血管性痴呆合并甲状腺功能减退发生率的研究血管性痴呆合并甲状腺功能减退发生率的研究(1)
摘 要：目的 探讨血管性痴呆患者合并甲状腺功能减退的几率是否较其他人群升高。方法 选取2014年12月～2016年12月我院收治的100例血管性痴呆患者为VD组，同时收集100例年龄匹配智力正常人群作为对照组，对两组人群进行甲状腺功能检测，比较两组FT3、FT4、TSH检测结果以及甲状腺功能减退发生率。结果 VD组中甲状腺功能减退发生率为21.00%，高于对照组的6.00%，差异具有统计学意义(P<0.05)。VD组FT3和FT4水平分别为(2.85±0.55)nmol/L和(8.81±4.72)nmol/L，低于对照组的(5.31±1.25)nmol/L和(18.15±4.58)nmol/L，TSH水平为(8.14±4.43)μIU/ml，高于对照组的(2.54±1.76)μIU/ml，差异具有统计学意义(P<0.05)。结论 血管性痴呆合并甲状腺功能减退的发生率高于正常人群。
关键词：血管性痴呆;甲状腺功能减退;FT3;FT4;TSH
中图分类号：R749.13;R581.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.21.029
, 百拇医药
文章编号：1006-1959(2018)21-0106-03
Study on the Incidence of Vascular Dementia Complicated with Hypothyroidism
JIN Feng，XIAO Meng
(Xinjiang Mental Health Center/Department of Emergency，the Fourth People's Hospital of Urumqi， Urumqi 830002，Xinjiang，China)
Abstract：Objective To investigate whether the incidence of hypothyroidism in patients with vascular dementia is higher than in other populations. Methods From December 2014 to December 2016， 100 patients with vascular dementia admitted to our hospital were selected as VD group， and 100 age-matched normal people were collected as control group. The thyroid function test was performed in the two groups. Group FT3， FT4， TSH test results and incidence of hypothyroidism.Results The incidence of hypothyroidism in the VD group was 21.00%， which was higher than that of the control group 6.00%，the difference was statistically significant (P<0.05). The levels of FT3 and FT4 in the VD group were (2.85±0.55) nmol/L and (8.81±4.72) nmol/L， respectively， which were lower than that of the control group (5.31±1.25) nmol/L and (18.15±4.58) nmol/L， the TSH level was (8.14±4.43) μIU/ml， which was higher than that of the control group (2.54±1.76) μIU/ml，the difference was statistically significant(P<0.05). Conclusion The incidence of vascular dementia with hypothyroidism is higher than that of the normal population.
, 百拇医药
Key words：vascular dementia; hypothyroidism; FT3; FT4; TSH
甲狀腺素是保持体温恒定，调节人体脂肪、糖、蛋白质代谢，促进人体生长发育的重要物质，其功能异常可导致多系统、多器官受损[1]。甲状腺激素对中枢神经系统的分化、发育及多种功能的形成起着十分关键的作用，对已分化成熟的神经系统活动也起到维持功能作用[2]，甲状腺功能低下时，中枢神经系统兴奋性降低，出现神经系统智力和记忆力减退、表情淡漠、感觉迟钝、行为迟缓、嗜睡，晚期重症者可出现精神失常、木僵和痴呆，甚至昏迷等[3]。由于老年人自身免疫的改变，易患免疫性疾患等因素，甲状腺功能减退在中老年人群中，随着年龄增长有发病率逐渐增多的流行病学特征[4]。甲状腺功能低下可加重了老年患者动脉粥样硬化的发生，也可通过动脉粥样硬化途径加重老年甲状腺功能低下患者的认知损害。血管性痴呆的发病机制较为复杂，尚未完全明确，但很可能是多个机制协同作用导致。与血管性痴呆有关的危险因素有多种，本研究通过定量分析筛查100例血管性痴呆患者甲状腺功能，从而了解血管性痴呆患者合并甲状腺功能减退的几率是否较其他人群升高，甲状腺功能减退是否成为血管性痴呆的危险因素。, 百拇医药(金 凤 肖 萌)
关键词：血管性痴呆;甲状腺功能减退;FT3;FT4;TSH
中图分类号：R749.13;R581.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.21.029
, 百拇医药
文章编号：1006-1959(2018)21-0106-03
Study on the Incidence of Vascular Dementia Complicated with Hypothyroidism
JIN Feng，XIAO Meng
(Xinjiang Mental Health Center/Department of Emergency，the Fourth People's Hospital of Urumqi， Urumqi 830002，Xinjiang，China)
Abstract：Objective To investigate whether the incidence of hypothyroidism in patients with vascular dementia is higher than in other populations. Methods From December 2014 to December 2016， 100 patients with vascular dementia admitted to our hospital were selected as VD group， and 100 age-matched normal people were collected as control group. The thyroid function test was performed in the two groups. Group FT3， FT4， TSH test results and incidence of hypothyroidism.Results The incidence of hypothyroidism in the VD group was 21.00%， which was higher than that of the control group 6.00%，the difference was statistically significant (P<0.05). The levels of FT3 and FT4 in the VD group were (2.85±0.55) nmol/L and (8.81±4.72) nmol/L， respectively， which were lower than that of the control group (5.31±1.25) nmol/L and (18.15±4.58) nmol/L， the TSH level was (8.14±4.43) μIU/ml， which was higher than that of the control group (2.54±1.76) μIU/ml，the difference was statistically significant(P<0.05). Conclusion The incidence of vascular dementia with hypothyroidism is higher than that of the normal population.
, 百拇医药
Key words：vascular dementia; hypothyroidism; FT3; FT4; TSH
甲狀腺素是保持体温恒定，调节人体脂肪、糖、蛋白质代谢，促进人体生长发育的重要物质，其功能异常可导致多系统、多器官受损[1]。甲状腺激素对中枢神经系统的分化、发育及多种功能的形成起着十分关键的作用，对已分化成熟的神经系统活动也起到维持功能作用[2]，甲状腺功能低下时，中枢神经系统兴奋性降低，出现神经系统智力和记忆力减退、表情淡漠、感觉迟钝、行为迟缓、嗜睡，晚期重症者可出现精神失常、木僵和痴呆，甚至昏迷等[3]。由于老年人自身免疫的改变，易患免疫性疾患等因素，甲状腺功能减退在中老年人群中，随着年龄增长有发病率逐渐增多的流行病学特征[4]。甲状腺功能低下可加重了老年患者动脉粥样硬化的发生，也可通过动脉粥样硬化途径加重老年甲状腺功能低下患者的认知损害。血管性痴呆的发病机制较为复杂，尚未完全明确，但很可能是多个机制协同作用导致。与血管性痴呆有关的危险因素有多种，本研究通过定量分析筛查100例血管性痴呆患者甲状腺功能，从而了解血管性痴呆患者合并甲状腺功能减退的几率是否较其他人群升高，甲状腺功能减退是否成为血管性痴呆的危险因素。, 百拇医药(金 凤 肖 萌)