甲状腺激素测定在高血压心力衰竭患者中的临床意义(1)
摘 要：目的 探討高血压合并心力衰竭患者体内的甲状腺激素水平变化情况及其临床意义。方法 选择2016年3月～2018年3月收住我院的原发性高血压患者共173例，根据患者是否合并心功能衰竭分为心衰组123例和对照组50例。心衰组患者按NYHA心功能分级标准进行分级，心功能Ⅱ级40例，Ⅲ级48例，Ⅳ级35例。心衰组患者常规予降压及抗心衰治疗，对照组患者仅予降压治疗，观察对比两组患者的甲状腺激素水平、B型利钠肽前体、射血分数水平等指标。比较各组间临床资料，采用Pearson相关性分析甲状腺激素水平与BNP、LVEF的关系。结果 心衰组患者的TT3、FT3、LVEF均低于对照组，差异具有统计学意义(P<0.05)，心衰组与对照组TT4、FT4、TSH比较，差异无统计学意义(P>0.05)。随心衰组患者心功能分级的加重，TT3、FT3、LVEF水平呈依次下降趋势，BNP升高，差异有统计学意义(P<0.05)。BNP与TT3、FT3、LVEF呈负相关(r=-0.508、-0.251、-0.283，P<0.01)，LVEF与TT3呈正相关(r=0.658，P<0.01)。结论 高血压心力衰竭患者常伴有甲状腺激素代谢紊乱，其中TT3、FT3水平在一定程度上能反映心力衰竭严重程度。
, 百拇医药
关键词：高血压；甲状腺激素；心力衰竭；正常甲状腺功能病态综合征
中图分类号：R541.6；R544.1；R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.22.026
文章编号：1006-1959(2018)22-0096-04
Clinical Signifcance of Changes of Serum Thyroid Hormone Levels in Hypertensive
Patients with Chronic Heart Failure
YANG Jin-long1，LIU Huan2
(Department of Cardiology1，Department of Endocrinology2，People's Hospital of Leshan，Leshan 614000，Sichuan，China)
, 百拇医药
Abstract：Objective To investigate the change and clinical signifcance of serum thyroid hormone levels in hypertensive patients with chronic heart failure.Methods A total of 173 patients with essential hypertension admitted to our hospital from March 2016 to March 2018 were enrolled. According to whether the patients with heart failure were divided into heart failure group (123 cases) and control group (50 cases). Patients with heart failure were graded according to NYHA cardiac function grading criteria. 40 patients with grade II cardiac function， 48 patients with grade III， and 35 patients with grade IV. Patients in the heart failure group were treated with antihypertensive and anti-heart failure. The patients in the control group were treated with antihypertensive therapy. The thyroid hormone levels， B-type natriuretic peptide precursors， and ejection fraction levels were compared between the two groups. The clinical data of each group were compared， and the relationship between thyroid hormone levels and BNP and LVEF was analyzed by Pearson correlation.Results The TT3， FT3 and LVEF of the patients with heart failure were lower than those of the control group， the difference was statistically significant (P<0.05). There was no significant difference between the heart failure group and the control group TT4， FT4 and TSH (P>0.05). The heart function grading of patients with heart failure group increased， TT3， FT3， LVEF levels decreased in turn， BNP increased， the difference was statistically significant (P<0.05). BNP was negatively correlated with TT3， FT3 and LVEF (r=-0.508，-0.251，-0.283， P<0.01)， and LVEF was positively correlated with TT3 (r=0.658， P<0.01). Conclusion Hypertensive heart failure patients are often accompanied by thyroid hormone metabolism disorders， and the levels of TT3 and FT3 can reflect the severity of heart failure to a certain extent., http://www.100md.com(杨锦龙 刘欢)
, 百拇医药
关键词：高血压；甲状腺激素；心力衰竭；正常甲状腺功能病态综合征
中图分类号：R541.6；R544.1；R446.11 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.22.026
文章编号：1006-1959(2018)22-0096-04
Clinical Signifcance of Changes of Serum Thyroid Hormone Levels in Hypertensive
Patients with Chronic Heart Failure
YANG Jin-long1，LIU Huan2
(Department of Cardiology1，Department of Endocrinology2，People's Hospital of Leshan，Leshan 614000，Sichuan，China)
, 百拇医药
Abstract：Objective To investigate the change and clinical signifcance of serum thyroid hormone levels in hypertensive patients with chronic heart failure.Methods A total of 173 patients with essential hypertension admitted to our hospital from March 2016 to March 2018 were enrolled. According to whether the patients with heart failure were divided into heart failure group (123 cases) and control group (50 cases). Patients with heart failure were graded according to NYHA cardiac function grading criteria. 40 patients with grade II cardiac function， 48 patients with grade III， and 35 patients with grade IV. Patients in the heart failure group were treated with antihypertensive and anti-heart failure. The patients in the control group were treated with antihypertensive therapy. The thyroid hormone levels， B-type natriuretic peptide precursors， and ejection fraction levels were compared between the two groups. The clinical data of each group were compared， and the relationship between thyroid hormone levels and BNP and LVEF was analyzed by Pearson correlation.Results The TT3， FT3 and LVEF of the patients with heart failure were lower than those of the control group， the difference was statistically significant (P<0.05). There was no significant difference between the heart failure group and the control group TT4， FT4 and TSH (P>0.05). The heart function grading of patients with heart failure group increased， TT3， FT3， LVEF levels decreased in turn， BNP increased， the difference was statistically significant (P<0.05). BNP was negatively correlated with TT3， FT3 and LVEF (r=-0.508，-0.251，-0.283， P<0.01)， and LVEF was positively correlated with TT3 (r=0.658， P<0.01). Conclusion Hypertensive heart failure patients are often accompanied by thyroid hormone metabolism disorders， and the levels of TT3 and FT3 can reflect the severity of heart failure to a certain extent., http://www.100md.com(杨锦龙 刘欢)