尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床疗效观察(1)
摘 要：目的 比较尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床效果。方法 选取2017年2月～2018年4月在我院接受治疗的77例老年偏头痛患者，随机分为A组39例和B组38例。A组患者采用盐酸氟桂利嗪治疗，B组患者采用尼莫地平治疗，比较用药前后两组患者头痛发作情况、疼痛程度、临床疗效与副作用。结果 A组发作次数少于B组[(0.62±0.19)次vs(1.13±0.32)次]，差异有统计学意义(P<0.05)；A组发作持续时间少于B组[(1.15±0.34)h vs(2.58±0.57)h]，差異有统计学意义(P<0.05)；A组患者NRS评分为(2.36±0.54)分，低于B组的(4.39±0.71)分，差异有统计学意义(P<0.05)；A组总有效率高于B组，差异有统计学意义(P<0.05)，两组副作用发生率比较，差异无统计学意义(P>0.05)。结论 相较于尼莫地平，应用盐酸氟桂利嗪治疗老年偏头痛可减少偏头痛发作次数，缩短发作持续时间，减轻疼痛、改善治疗效果，同时药物副作用较低。
关键词：尼莫地平；盐酸氟桂利嗪；偏头痛
, http://www.100md.com
中图分类号：R747.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.22.044
文章编号：1006-1959(2018)22-0150-03
Clinical Efficacy of Nimodipine and Flunarizine Hydrochloride in the Treatment of Senile Migraine
PENG Ying-ping
(Department of Pharmacy，Tianjin Xiqing Hospital，Tianjin 300380，China)
Abstract：Objective To compare the clinical effects of nimodipine and flunarizine hydrochloride in the treatment of senile migraine.Methods 77 elderly patients with migraine who were treated in our hospital from February 2017 to April 2018 were randomly divided into group A (n=39) and group B (n=38). Patients in group A were treated with flunarizine hydrochloride， and patients in group B were treated with nimodipine. The symptoms of headache， pain， clinical efficacy and side effects were compared between the two groups before and after treatment.Results The number of seizures in group A was less than that in group B [(0.62±0.19) vs. (1.13±0.32) times]， the difference was statistically significant (P<0.05)； the duration of seizures in group A was less than that in group B [(1.15±0.34) h vs (2.58±0.57) h]， the difference was statistically significant (P<0.05)； the NRS score of group A was (2.36±0.54)， lower than that of group B (4.39±0.71)， the difference was statistically significant(P<0.05)； the total effective rate of group A was higher than that of group B， the difference was statistically significant (P<0.05). There was no significant difference in the incidence of side effects between the two groups (P>0.05). Conclusion Compared with nimodipine， the application of flunarizine hydrochloride in the treatment of senile migraine can reduce the number of migraine attacks， shorten the duration of attacks， reduce pain， improve the treatment effect， and have lower side effects.
Key words：Nimodipine；Flunarizine hydrochloride；Migraine
偏头痛(migraine)为发病率较高的周期性发作慢性神经血管疾病，发病部位通常为一侧或两侧颞部，发作时伴有呕吐表现，且疼痛持续时间较长[1]。其多发于女性群体，不仅会降低患者生存质量，还会给其生命健康造成严重威胁。老年偏头痛患者身体机能下降，面临着更高的治疗难度，现代医学尚未出现有效的根治方式，且现阶段使用的药物普通存在毒副作用多、禁忌证多等问题。研究有效、安全性高的治疗方案在临床上广受关注。本次研究比较尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床效果，现报道如下。, 百拇医药(彭莹萍)
关键词：尼莫地平；盐酸氟桂利嗪；偏头痛
, http://www.100md.com
中图分类号：R747.2 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.22.044
文章编号：1006-1959(2018)22-0150-03
Clinical Efficacy of Nimodipine and Flunarizine Hydrochloride in the Treatment of Senile Migraine
PENG Ying-ping
(Department of Pharmacy，Tianjin Xiqing Hospital，Tianjin 300380，China)
Abstract：Objective To compare the clinical effects of nimodipine and flunarizine hydrochloride in the treatment of senile migraine.Methods 77 elderly patients with migraine who were treated in our hospital from February 2017 to April 2018 were randomly divided into group A (n=39) and group B (n=38). Patients in group A were treated with flunarizine hydrochloride， and patients in group B were treated with nimodipine. The symptoms of headache， pain， clinical efficacy and side effects were compared between the two groups before and after treatment.Results The number of seizures in group A was less than that in group B [(0.62±0.19) vs. (1.13±0.32) times]， the difference was statistically significant (P<0.05)； the duration of seizures in group A was less than that in group B [(1.15±0.34) h vs (2.58±0.57) h]， the difference was statistically significant (P<0.05)； the NRS score of group A was (2.36±0.54)， lower than that of group B (4.39±0.71)， the difference was statistically significant(P<0.05)； the total effective rate of group A was higher than that of group B， the difference was statistically significant (P<0.05). There was no significant difference in the incidence of side effects between the two groups (P>0.05). Conclusion Compared with nimodipine， the application of flunarizine hydrochloride in the treatment of senile migraine can reduce the number of migraine attacks， shorten the duration of attacks， reduce pain， improve the treatment effect， and have lower side effects.
Key words：Nimodipine；Flunarizine hydrochloride；Migraine
偏头痛(migraine)为发病率较高的周期性发作慢性神经血管疾病，发病部位通常为一侧或两侧颞部，发作时伴有呕吐表现，且疼痛持续时间较长[1]。其多发于女性群体，不仅会降低患者生存质量，还会给其生命健康造成严重威胁。老年偏头痛患者身体机能下降，面临着更高的治疗难度，现代医学尚未出现有效的根治方式，且现阶段使用的药物普通存在毒副作用多、禁忌证多等问题。研究有效、安全性高的治疗方案在临床上广受关注。本次研究比较尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床效果，现报道如下。, 百拇医药(彭莹萍)