年龄对胃部常见良性疾病患者的胃蛋白酶原及胃泌素—17水平的影响(1)
摘 要：目的 研究年龄对胃部常见良性疾病患者的胃蛋白酶原(PG)及胃泌素-17(G-17)水平的影响。方法 收集2016年1月～2017年12月在安徽医科大学附属安庆医院消化内科住院患者的病历作为研究材料，根据疾病将其分为慢性非萎缩性胃炎(CNAG)组、胃息肉組及胃溃疡组，共收集2638份符合条件的病历。将上述三组疾病按照年龄进一步分为高龄亚组(≥60岁)及低龄亚组(<60岁)，每个亚组按男女性别再分为两个次级亚组。按照随机数字表法，将符合条件的患者资料随机分到每个次级亚组中，每组40例，一共收集480例资料作为样本进行分析。使用双抗体夹心法的酶学免疫分析技术检测各组患者的胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及G-17水平，并计算出PGⅠ/PGⅡ的比值PGR。结果 在CNAG及胃息肉组中，高龄亚组的PGⅠ、PGⅡ和G-17水平均高于低龄亚组、PGR水平低于低龄亚组，差异有统计学意义(P<0.05)。在胃溃疡组中，高龄亚组的PGⅠ、PGⅡ及G-17水平均高于低龄亚组、PGR水平低于低龄亚组，差异无统计学意义(P>0.05)。结论 在CNAG及胃息肉组中，年龄对胃蛋白酶原及G-17水平有影响，但在胃溃疡组中，年龄对胃蛋白酶原及G-17水平的无明显影响。
, 百拇医药
关键词：年龄；非萎缩性胃炎；胃息肉；胃溃疡；胃蛋白酶原；胃泌素-17
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.028
文章编号：1006-1959(2018)23-0105-03
Abstract：Objective The effect of age on pepsinogen (PG) and gastrin-17(G-17) levels in patients with common benign diseases of the stomach was studied. Methods From January 2016 to December 2017， the medical records of inpatients in the Department of Gastroenterology， Anqing Hospital affiliated to Anhui Medical University were collected as research materials. According to the disease， they were divided into chronic non-atrophic gastritis(CNAG) group， gastric polyp group and gastric ulcer. Group， a total of 2638 eligible medical records were collected. The above three groups of diseases were further divided into the older subgroup (≥60 years old) and the younger subgroup(<60 years old) according to age， and each subgroup was subdivided into two subgroups according to gender. According to the random number table method， the eligible patient data were randomly assigned to each sub-subgroup， 40 cases in each group， and a total of 480 samples were collected for analysis. The pepsinogen I(PGI)， pepsinogen II (PGII) and G-17 levels of each group of patients were measured by enzymatic immunoassay using a double antibody sandwich method， and the PGI/PGII ratio PGR was calculated. Results In the CNAG and gastric polyp group， the PGI， PGII and G-17 levels in the older subgroup were higher than those in the younger subgroup and the PGR level was lower than the lower subgroup，the difference was statistically significant(P<0.05). In the gastric ulcer group， the PGI， PGII and G-17 levels in the older age group were higher than those in the younger subgroup and the PGR level was lower than the younger subgroup， and the difference was not statistically significant(P>0.05). Conclusion Age has an effect on pepsinogen and G-17 levels in the CNAG and gastric polyp groups， but in the gastric ulcer group， age has no significant effect on pepsinogen and G-17 levels., 百拇医药(潮子健 汪文生 谢宏伟)
, 百拇医药
关键词：年龄；非萎缩性胃炎；胃息肉；胃溃疡；胃蛋白酶原；胃泌素-17
中图分类号：R573 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.23.028
文章编号：1006-1959(2018)23-0105-03
Abstract：Objective The effect of age on pepsinogen (PG) and gastrin-17(G-17) levels in patients with common benign diseases of the stomach was studied. Methods From January 2016 to December 2017， the medical records of inpatients in the Department of Gastroenterology， Anqing Hospital affiliated to Anhui Medical University were collected as research materials. According to the disease， they were divided into chronic non-atrophic gastritis(CNAG) group， gastric polyp group and gastric ulcer. Group， a total of 2638 eligible medical records were collected. The above three groups of diseases were further divided into the older subgroup (≥60 years old) and the younger subgroup(<60 years old) according to age， and each subgroup was subdivided into two subgroups according to gender. According to the random number table method， the eligible patient data were randomly assigned to each sub-subgroup， 40 cases in each group， and a total of 480 samples were collected for analysis. The pepsinogen I(PGI)， pepsinogen II (PGII) and G-17 levels of each group of patients were measured by enzymatic immunoassay using a double antibody sandwich method， and the PGI/PGII ratio PGR was calculated. Results In the CNAG and gastric polyp group， the PGI， PGII and G-17 levels in the older subgroup were higher than those in the younger subgroup and the PGR level was lower than the lower subgroup，the difference was statistically significant(P<0.05). In the gastric ulcer group， the PGI， PGII and G-17 levels in the older age group were higher than those in the younger subgroup and the PGR level was lower than the younger subgroup， and the difference was not statistically significant(P>0.05). Conclusion Age has an effect on pepsinogen and G-17 levels in the CNAG and gastric polyp groups， but in the gastric ulcer group， age has no significant effect on pepsinogen and G-17 levels., 百拇医药(潮子健 汪文生 谢宏伟)