地塞米松对甲状腺切除术后自控镇痛恶心呕吐发生率的影响(1)
摘 要：目的 观察地塞米松对全身麻醉下甲状腺切除术后患者自控静脉镇痛(PCIA)引起恶心呕吐发生率的影响。方法 选择我院择期全身麻醉下实施甲状腺切除术术后应用自控静脉镇痛泵的患者50例作为实验对象，隨机分为A组和B组，每组25例。A组为实验组，自控静脉镇痛泵中药物使用包括地塞米松、地佐辛、帕洛诺司琼、舒芬太尼、生理盐水;B组为对照组，自控静脉镇痛泵中药物使用包括地佐辛、帕洛诺司琼、舒芬太尼、生理盐水。对比术后两组患者48 h内恶心呕吐发生率，术后1、4、8、24、48 h的VAS评分。结果 A组48 h内恶心、呕吐发生率分别为20.00%、16.00%，均低于对照组的60.00%和56.00%，差异具有统计学意义(P<0.05)。两组术后1、4、8、24、48 h的VAS评分相比，差异无统计学意义(P>0.05)。结论 地塞米松可以有效降低甲状腺切除术患者术后自控镇痛恶心呕吐的发生率，减少止吐药物的使用，减少患者术后的不良反应，提高了患者的满意度和安全性。
关键词：地塞米松;甲状腺切除术;术后恶心呕吐;镇痛
, http://www.100md.com
中图分类号：R614 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.24.028
文章编号：1006-1959(2018)24-0101-04
Abstract：Objective To observe the effect of dexamethasone on the incidence of nausea and vomiting caused by controlled intravenous analgesia (PCIA) in patients undergoing thyroidectomy under general anesthesia. Methods A total of 50 patients with self-controlled intravenous analgesia after thyroidectomy under general anesthesia were selected as subjects. They were randomly divided into group A and group B， with 25 cases in each group. Group A was the experimental group， and the drug used in the self-controlled intravenous analgesia pump included dexamethasone， dextrozine， palonosetron， sufentanil， and saline; group B was the control group， and the drug in the self-controlled intravenous analgesia pump Uses include dexrazin， palonosetron， sufentanil， and saline. The incidence of nausea and vomiting was compared within 48 h after operation， and the VAS scores were 1， 4， 8， 24， 48 h after operation. Results The incidence of nausea and vomiting in group A was 20.00% and 16.00%， respectively， which were lower than 60.00% and 56.00% of the control group， the difference was statistically significant (P<0.05). There was no significant difference in VAS scores between the two groups at 1， 4， 8， 24， and 48 h after surgery (P>0.05). Conclusion Dexamethasone can effectively reduce the incidence of postoperative self-controlled analgesia， nausea and vomiting in patients undergoing thyroidectomy， reduce the use of antiemetic drugs， reduce postoperative adverse reactions， improve patient satisfaction and safety， and improve the patient's satisfaction and safety.
Key words：Dexamethasone;Thyroidectomy;Postoperative nausea and vomiting;Analgesia, 百拇医药(赵宏玉 杨爱民)
关键词：地塞米松;甲状腺切除术;术后恶心呕吐;镇痛
, http://www.100md.com
中图分类号：R614 文献标识码：A DOI：10.3969/j.issn.1006-1959.2018.24.028
文章编号：1006-1959(2018)24-0101-04
Abstract：Objective To observe the effect of dexamethasone on the incidence of nausea and vomiting caused by controlled intravenous analgesia (PCIA) in patients undergoing thyroidectomy under general anesthesia. Methods A total of 50 patients with self-controlled intravenous analgesia after thyroidectomy under general anesthesia were selected as subjects. They were randomly divided into group A and group B， with 25 cases in each group. Group A was the experimental group， and the drug used in the self-controlled intravenous analgesia pump included dexamethasone， dextrozine， palonosetron， sufentanil， and saline; group B was the control group， and the drug in the self-controlled intravenous analgesia pump Uses include dexrazin， palonosetron， sufentanil， and saline. The incidence of nausea and vomiting was compared within 48 h after operation， and the VAS scores were 1， 4， 8， 24， 48 h after operation. Results The incidence of nausea and vomiting in group A was 20.00% and 16.00%， respectively， which were lower than 60.00% and 56.00% of the control group， the difference was statistically significant (P<0.05). There was no significant difference in VAS scores between the two groups at 1， 4， 8， 24， and 48 h after surgery (P>0.05). Conclusion Dexamethasone can effectively reduce the incidence of postoperative self-controlled analgesia， nausea and vomiting in patients undergoing thyroidectomy， reduce the use of antiemetic drugs， reduce postoperative adverse reactions， improve patient satisfaction and safety， and improve the patient's satisfaction and safety.
Key words：Dexamethasone;Thyroidectomy;Postoperative nausea and vomiting;Analgesia, 百拇医药(赵宏玉 杨爱民)