妇女宫颈病变筛查分析(1)
摘要：目的 研究HPV与宫颈癌及癌前病变的相关性，提供防治宫颈癌的思路。方法 以2012年1月～2017 年12月送检到浙江迪安诊断技术股份有限公司的433447例宫颈病变标本为研究对象，同时检测人乳头瘤病毒(HPV)基因分型和薄层液基细胞学(TCT)，并分析HPV基因亚型分布及年龄分布。结果 HPV阳性率为12.51%，其中单一高危HPV阳性率为9.28%，单一低危HPV阳性率为1.22%。HPV亚型阳性率最高的是16型2.09%、58型1.82%、52型1.61%。TCT 阳性检出率是5.69%，其中 ASC-US3.91%、LSIL1.21%、ASC-H0.32%、HSIL及以上0.23%、AGC 0.02%。HPV发病率最高的年龄段是41～50岁，阳性率为5.54%，与其它年龄段比较，差异有统计学意义(P<0.05)。结论 HPV亚型中16、52及58感染率最高，同时具有明显年龄特征。HPV感染可引起一系列的宫颈病变，防治重点应针对高危HPV感染的人群。
关键词：宫颈病变;HPV;TCT;宫颈癌
, 百拇医药
中图分类号：R737.33 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.043
文章编号：1006-1959(2019)01-0139-03
Screening Analysis of Cervical Lesions in Women
ZHU Jun，ZHANG Zhen-jun
(Zhejiang Dian Medical Testing Center Co.，Ltd.，Hangzhou 310030，Zhejiang，China)
Abstract：Objective To study the correlation between HPV and cervical cancer and precancerous lesions， and to provide ideas for the prevention and treatment of cervical cancer. Methods From January 2012 to December 2017， 433，447 cases of cervical lesions were sent to Zhejiang Dian Diagnostics Technology Co.， Ltd. for the detection of human papillomavirus (HPV) genotyping and thin-layer liquid-based cells. (TCT)， and analysis of HPV gene subtype distribution and age distribution.Results The positive rate of HPV was 12.51%， of which the single high-risk HPV positive rate was 9.28%， and the single low-risk HPV positive rate was 1.22%. The highest positive rates of HPV subtypes were type 16 (2.09%)， type 58 (1.82%)， and type 52 (1.61%). The positive rate of TCT was 5.69%， including ASC-US (3.91%)， LSIL (1.21%)， ASC-H (0.32%)， HSIL and above (0.23%)， and glandular epithelial lesions (0.02%). The age group with the highest incidence of HPV was 41-50 years old， and the positive rate was 5.54%. Compared with other age groups， the difference was statistically significant (P<0.05).Conclusion The HPV subtypes have the highest infection rates of 16， 52 and 58 and have obvious age characteristics. HPV infection can cause a series of cervical lesions， and the focus should be on people with high-risk HPV infection.
, 百拇医药
Key words：Cervical lesions;HPV;TCT;Cervical cancer
宮颈癌(cervical cancer)严重威胁妇女健康及生命，是发病率仅次于乳腺癌的恶性肿瘤，位于第2位[1];我国宫颈癌病人、死亡人数均占世界的1/3，每年增长速度约为2%～3%，发病年龄愈发呈现年轻化[2，3]。2008年诺贝尔医学奖得主楚尔·豪森研究表明，HPV引起女性发生宫颈癌，高危型HPV的持续性感染能够引起宫颈癌及宫颈癌前病变，这为宫颈癌的治疗以及预防明确了方向[4]。宫颈癌是目前仅有的病因明确，能够早期发现、预防和治疗，并有望完全根除的癌症。因此，HPV检测对妇女宫颈方面疾病的筛查具有重要价值。本研究对送检的433447例患者同时进行HPV检测与TCT，研究各HPV各亚型、年龄因素与宫颈病变的关联性。, 百拇医药(朱军 张振君)
关键词：宫颈病变;HPV;TCT;宫颈癌
, 百拇医药
中图分类号：R737.33 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.01.043
文章编号：1006-1959(2019)01-0139-03
Screening Analysis of Cervical Lesions in Women
ZHU Jun，ZHANG Zhen-jun
(Zhejiang Dian Medical Testing Center Co.，Ltd.，Hangzhou 310030，Zhejiang，China)
Abstract：Objective To study the correlation between HPV and cervical cancer and precancerous lesions， and to provide ideas for the prevention and treatment of cervical cancer. Methods From January 2012 to December 2017， 433，447 cases of cervical lesions were sent to Zhejiang Dian Diagnostics Technology Co.， Ltd. for the detection of human papillomavirus (HPV) genotyping and thin-layer liquid-based cells. (TCT)， and analysis of HPV gene subtype distribution and age distribution.Results The positive rate of HPV was 12.51%， of which the single high-risk HPV positive rate was 9.28%， and the single low-risk HPV positive rate was 1.22%. The highest positive rates of HPV subtypes were type 16 (2.09%)， type 58 (1.82%)， and type 52 (1.61%). The positive rate of TCT was 5.69%， including ASC-US (3.91%)， LSIL (1.21%)， ASC-H (0.32%)， HSIL and above (0.23%)， and glandular epithelial lesions (0.02%). The age group with the highest incidence of HPV was 41-50 years old， and the positive rate was 5.54%. Compared with other age groups， the difference was statistically significant (P<0.05).Conclusion The HPV subtypes have the highest infection rates of 16， 52 and 58 and have obvious age characteristics. HPV infection can cause a series of cervical lesions， and the focus should be on people with high-risk HPV infection.
, 百拇医药
Key words：Cervical lesions;HPV;TCT;Cervical cancer
宮颈癌(cervical cancer)严重威胁妇女健康及生命，是发病率仅次于乳腺癌的恶性肿瘤，位于第2位[1];我国宫颈癌病人、死亡人数均占世界的1/3，每年增长速度约为2%～3%，发病年龄愈发呈现年轻化[2，3]。2008年诺贝尔医学奖得主楚尔·豪森研究表明，HPV引起女性发生宫颈癌，高危型HPV的持续性感染能够引起宫颈癌及宫颈癌前病变，这为宫颈癌的治疗以及预防明确了方向[4]。宫颈癌是目前仅有的病因明确，能够早期发现、预防和治疗，并有望完全根除的癌症。因此，HPV检测对妇女宫颈方面疾病的筛查具有重要价值。本研究对送检的433447例患者同时进行HPV检测与TCT，研究各HPV各亚型、年龄因素与宫颈病变的关联性。, 百拇医药(朱军 张振君)