抗结核药物治疗所致肝损伤患者的危险因素及其治疗转归观察(1)
摘要：目的 探讨抗结核药物治疗所致肝损伤患者的危险因素及其治疗转归。方法 回顾性分析我院自2013年1月～2017年1月收治的1033例抗结核治疗患者的临床资料，其中158例患者发生抗结核药物所致肝损伤(DILD)，统计分析所有患者性别、年龄、肝病史、酗酒、营养不良、痰菌情况。采用Logistics多因素回归分析法分析患者发生DILD的危险因素及治疗转归情况。结果 1033例抗结核治疗患者中，出现DILD为158例，发生率15.30%，年龄、肝病史、酗酒、营养不良、痰菌阳性是DILD的危险因素(P<0.05);158例DILD患者经治疗后，治疗成功150例(94.94%)，治疗失败8例(5.06%)。结论 年龄、肝病史、酗酒、营养不良、痰菌阳性是DILD的危险因素，临床上应重点监测危险人群用药情况，及时调整治疗方案，降低DILD发生率，促使患者顺利完成化疗。
关键词：抗结核药物;肺结核;肝损伤;危险因素;治疗转归;痰菌阳性
中图分类号：R97;R52 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.03.051
, 百拇医药
文章编号：1006-1959(2019)03-0155-03
Abstract：Objective To investigate the risk factors and treatment outcomes of patients with liver injury caused by anti-tuberculosis drugs. Methods The clinical data of 1033 anti-tuberculosis patients admitted to our hospital from January 2013 to January 2017 were retrospectively analyzed. Among them， 158 patients developed liver damage caused by anti-tuberculosis drugs (DILD)， and all patients were statistically analyzed. Age， history of liver disease， alcoholism， malnutrition， and sputum. Logistics multivariate regression analysis was used to analyze the risk factors and treatment outcomes of patients with DILD. Results Among 1033 anti-tuberculosis patients， 158 cases had DILD， the incidence rate was 15.30%. Age， liver disease history， alcoholism， malnutrition， and sputum positive were risk factors for DILD (P<0.05). After treatment of 158 patients with DILD， 150 patients (94.94%) were successfully treated and 8 patients (5.06%) were treated with failure. Conclusion Age， liver disease history， alcoholism， malnutrition， and sputum positive are risk factors for DILD. Clinically， it is necessary to monitor the drug use of dangerous people， adjust the treatment plan in time， reduce the incidence of DILD， and prompt patients to successfully complete chemotherapy.
, 百拇医药
Key words：Anti-tuberculosis drugs;Tuberculosis;Liver injury;Risk factors;Treatment outcome; Sputum positive
抗結核药物治疗所致肝损伤(drug-induced liver disease，DILD)是肺结核患者化疗期间常见并发症，其发生率大约为8%～30%，DILD是造成结核病患者中止治疗的重要原因[1]。DILD一旦发生而不及时处理，将会威胁患者的生命安全。抗结核药物治疗中，掌握患者发生DILD的危险因素，有助于临床医师判断药物性肝损伤的发生及发展，加强监测危险人群，及时调整化疗方案，降低DILD发生率，提高患者抗结核治疗依从性。本研究对我院2015年1月～2017年1月发生DILD的患者158例的临床资料进行回顾性分析其危险因素及治疗转归，现报告如下。, 百拇医药(李新刚)
关键词：抗结核药物;肺结核;肝损伤;危险因素;治疗转归;痰菌阳性
中图分类号：R97;R52 文献标识码：A DOI：10.3969/j.issn.1006-1959.2019.03.051
, 百拇医药
文章编号：1006-1959(2019)03-0155-03
Abstract：Objective To investigate the risk factors and treatment outcomes of patients with liver injury caused by anti-tuberculosis drugs. Methods The clinical data of 1033 anti-tuberculosis patients admitted to our hospital from January 2013 to January 2017 were retrospectively analyzed. Among them， 158 patients developed liver damage caused by anti-tuberculosis drugs (DILD)， and all patients were statistically analyzed. Age， history of liver disease， alcoholism， malnutrition， and sputum. Logistics multivariate regression analysis was used to analyze the risk factors and treatment outcomes of patients with DILD. Results Among 1033 anti-tuberculosis patients， 158 cases had DILD， the incidence rate was 15.30%. Age， liver disease history， alcoholism， malnutrition， and sputum positive were risk factors for DILD (P<0.05). After treatment of 158 patients with DILD， 150 patients (94.94%) were successfully treated and 8 patients (5.06%) were treated with failure. Conclusion Age， liver disease history， alcoholism， malnutrition， and sputum positive are risk factors for DILD. Clinically， it is necessary to monitor the drug use of dangerous people， adjust the treatment plan in time， reduce the incidence of DILD， and prompt patients to successfully complete chemotherapy.
, 百拇医药
Key words：Anti-tuberculosis drugs;Tuberculosis;Liver injury;Risk factors;Treatment outcome; Sputum positive
抗結核药物治疗所致肝损伤(drug-induced liver disease，DILD)是肺结核患者化疗期间常见并发症，其发生率大约为8%～30%，DILD是造成结核病患者中止治疗的重要原因[1]。DILD一旦发生而不及时处理，将会威胁患者的生命安全。抗结核药物治疗中，掌握患者发生DILD的危险因素，有助于临床医师判断药物性肝损伤的发生及发展，加强监测危险人群，及时调整化疗方案，降低DILD发生率，提高患者抗结核治疗依从性。本研究对我院2015年1月～2017年1月发生DILD的患者158例的临床资料进行回顾性分析其危险因素及治疗转归，现报告如下。, 百拇医药(李新刚)