慢性乙型肝炎抗病毒治疗进展(7)
[45]Peppa D，Micco L，Javaid A，et al.Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection[J].PLoS Pathog，2010，6(12)：e1001227.
[46]Akhurst RJ，Hata A.Targeting the TGFβ signalling pathway in disease[J].Nat Rev Drug Discov，2012，11(10)：790-811.
[47]Manigold T，Racanelli V.T-cell regulation by CD4 regulatory T-cells during hepatitis B and C virus infections： facts and controversies[J].Lancet Infect Dis，2007，7(12)：804-813.
[48]Bertoletti A，Gehring A.Therapeutic vaccination and novel strategies to treat chronic HBV infection[J].Expert Rev Gastroenterol Hepatol，2009，3(5)：561-569.
[49]Lok AS，Pan CQ，Han SH，et al.Randomized phase Ⅱ study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B[J].J Hepatol，2016，65(3)：509-516.
[50]陸建国.聚乙二醇干扰素α-2a联合乙肝疫苗治疗慢性乙型肝炎疗效观察[J].实用肝脏病杂志，2014，17(1)：34-36.
[51]Wooddell CI，Rozema DB，Hossbach M，et al.Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection[J].Mol Ther，2013，21(5)：973-985.
收稿日期：2018-11-24;修回日期：2018-12-10
编辑/杨倩, 百拇医药(汪晓凤 邵和军)
[46]Akhurst RJ，Hata A.Targeting the TGFβ signalling pathway in disease[J].Nat Rev Drug Discov，2012，11(10)：790-811.
[47]Manigold T，Racanelli V.T-cell regulation by CD4 regulatory T-cells during hepatitis B and C virus infections： facts and controversies[J].Lancet Infect Dis，2007，7(12)：804-813.
[48]Bertoletti A，Gehring A.Therapeutic vaccination and novel strategies to treat chronic HBV infection[J].Expert Rev Gastroenterol Hepatol，2009，3(5)：561-569.
[49]Lok AS，Pan CQ，Han SH，et al.Randomized phase Ⅱ study of GS-4774 as a therapeutic vaccine in virally suppressed patients with chronic hepatitis B[J].J Hepatol，2016，65(3)：509-516.
[50]陸建国.聚乙二醇干扰素α-2a联合乙肝疫苗治疗慢性乙型肝炎疗效观察[J].实用肝脏病杂志，2014，17(1)：34-36.
[51]Wooddell CI，Rozema DB，Hossbach M，et al.Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection[J].Mol Ther，2013，21(5)：973-985.
收稿日期：2018-11-24;修回日期：2018-12-10
编辑/杨倩, 百拇医药(汪晓凤 邵和军)